Excited to have contributed to this collaborative work with Moremen Lab @CCRC. Glycobiology and structural biology come together to reveal how CHSY-CHPF complexes drive chondroitin sulfate polymer synthesis. Congratulations to all co-authors! www.nature.com/articles/s41...
nature.com
Structural basis of chondroitin sulfate backbone polymer synthesis - Nature Communications
Four homologous enzymes (CHPF1/2, CHSY1/3) form heterodimeric complexes essential for chondroitin sulfate synthesis. Cryo-EM and modeling show only CHSY glycosyltransferase domains catalyze polymer fo...