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Séb Wielgoss

@sebwielgoss.bsky.social
25 followers 34 following 2 posts

Senior Scientist, Microbiologist

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Reposted by Séb Wielgoss
Willem van Schaik @wvschaik.bsky.social · 08/11/2025
Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews academic.oup.com/femsre/advan... (accepted manuscript version) TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.
academic.oup.com
Resistance to last-resort antibiotics in enterococci
Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The
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Osterman Ilya @ostermanilya.bsky.social · 06/11/2025
Bacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇 www.biorxiv.org/content/10.1...
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Vaughn Cooper @vscooper.micropopbio.org · 05/11/2025
Love the idea of the "deletion test" posed by @needhibhalla.bsky.social & coauthors in their commentary about costs of cutting DEI efforts in science. What if that student were "deleted?" What will the costs be? Screenshots attached to enhance access. www.nature.com/articles/s41...
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Marc Robinson-Rechavi @marcrr.ecoevo.social.ap.brid.gy · 06/11/2025
The 2025 state of the climate report: a planet on the brink doi.org/10.1093/biosci/biaf149 #ClimateChange #ClimateScience
Approximate global average temperature from –9340 BCE to 2020 CE, showing a gradual increase then decrease until fossil fuel use accelerates ≈1850, after which there is a very rapid increase. A dotted line shows peak warming at +3°C by 2100 if currrent policies continue.
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Reposted by Séb Wielgoss
Willem van Schaik @wvschaik.bsky.social · 28/10/2025
Interesting paper 'Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019' TL;DR: - dramatic falls in MRSA - pneumococcal resistance rates low - E. faecium more prevalent (and more vanR) than E. faecalis pubmed.ncbi.nlm.nih.gov/41140273/
pubmed.ncbi.nlm.nih.gov
Antimicrobial resistance among Gram-positive agents of bacteraemia in the UK and Ireland: trends from 2001 to 2019 - PubMed
Gram-positive pathogens were the dominant historical pathogens of bacteraemia. The trends seen here-with many near-universally active antibiotics-indicate little hazard of this situation returning. Nevertheless, few treatments exist in some settings, notably multi-resistant E. faecium endocarditis.
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Willem van Schaik @wvschaik.bsky.social · 21/10/2025
Interesting paper on bacteriophage genomics and bioinformatics 'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues academic.oup.com/bib/article/...
academic.oup.com
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
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Teppo Hiltunen @teppo-h.bsky.social · 30/09/2025
Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share. duunitori.fi/tyopaikat/ty...
duunitori.fi
Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori
Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!
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Ákos T Kovács @evolvedbiofilm.bsky.social · 25/09/2025
Cool PNAS paper by @jordivangestel.bsky.social and colleagues Contributed by Carol Gross [reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social] Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation www.pnas.org/doi/10.1073/...
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Karthik Anantharaman @karthik-a.bsky.social · 27/08/2025
New paper alert! We suggest caution in the analyses of viral auxiliary metabolic genes and propose a new overarching term - 'auxiliary viral genes' (AVGs) to describe different types of such genes. @simrouxvirus.bsky.social #phagesky #Microsky www.nature.com/articles/s41...
nature.com
A call for caution in the biological interpretation of viral auxiliary metabolic genes - Nature Microbiology
This Perspective discusses virus-encoded auxiliary metabolic genes and provides a framework for the biological interpretation of these genes.
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Martin Polz @polzlab.bsky.social · 11/08/2025
Longstanding collaboration with Scott Manalis where we have developed technology to measure single cell growth rates of bacteria in native seawater with some very surprising results. www.biorxiv.org/content/10.1...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 18/09/2025
Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism #ApplEnvironMicrobiol from Jeff Barrick journals.asm.org/doi/10.1128/...
journals.asm.org
Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism | Applied and Environmental Microbiology
Acinetobacter baylyi ADP1 is a bacterial chassis of interest to microbiologists in academia and industry due to its extreme natural competence and wide metabolic range. Its ability to take up DNA from...
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Reposted by Séb Wielgoss
Jase Gehring @skyjase.bsky.social · 18/09/2025
very cool work and a milestone in synthetic biology. how impressive are the new phage genomes? with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look
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Agathe couturier @agathe-couturier.bsky.social · 17/09/2025
Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...
academic.oup.com
Exclusion systems preserve host cell homeostasis and fitness, ensuring successful dissemination of conjugative plasmids and associated resistance genes
Abstract. Plasmid conjugation is a major driver of antibiotic resistance dissemination in bacteria. In addition to genes required for transfer and maintena
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Geschichten aus der Geschichte @geschichte.fm · 16/07/2025
Mittwoch! Passend zur Sommerszeit: eine kleine Geschichte der Sonnenbrille. Wir sprechen nicht nur über ihre Anfänge, sondern vor allem über die Bedeutung, die sie im Laufe ihrer Geschichte erhalten hat. www.geschichte.fm/archiv/gag512
geschichte.fm
GAG512: Eine kleine Geschichte der Sonnenbrille - Geschichten aus der Geschichte
Eine Geschichte über Sonnenschutz, Identität und Rebellion
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Marc Robinson-Rechavi @marcrr.ecoevo.social.ap.brid.gy · 19/08/2025
@eseb Distinguished Fellow Talk Dieter Ebert 🇨🇭, has been an ESEB member since his PhD and played a key role in the society all of his career. #ESEB2025
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Dieter Lukas @dieterlukas.fediscience.org.ap.brid.gy · 15/09/2025
"Overall, the message from this survey is positive– #evolutionary #biologists are readily employable outside of #academia, generally well-prepared for those jobs, and report high levels of satisfaction in their non-academic #careers" www.biorxiv.org/content/10.1101/202…
A scientific figure from the linked paper by Betancourt et al. It shows on the left, that most (70%) evolutionary biologists who switched to a career outside of academia felt prepared. The right panel is a graph showing what training individuals would like to have received more of during their academic career, with the top points being related to management skills.
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Séb Wielgoss @sebwielgoss.bsky.social · 12/09/2025
Need advice on which of the many virus 🦠 prediction tools to apply for your phage research🔎? This guide equips you for your bioinformatic analyses in your "quest to explore the genetic diversity and biology of the smallest and most abundant replicators on Earth." ⬇️ doi.org/10.1093/bib/...
doi.org
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
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Reposted by Séb Wielgoss
Richard Lenski @relenski.bsky.social · 12/08/2025
Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime. telliamedrevisited.wordpress.com/2025/08/12/s... STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.
telliamedrevisited.wordpress.com
STEPS To It
Announcing a new program, called STEPS, to simulate the dynamics of evolving microbial populations.
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Carolin Wendling @ccwendling.bsky.social · 04/09/2025
Interested in exploring prophages in your (meta)genomes, but don't know how and where to start? We've put together a beginners guide to exploring viral diversity in prokaryotes @marievasse.bsky.social @sebwielgoss.bsky.social @oxunipress.bsky.social
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Séb Wielgoss @sebwielgoss.bsky.social · 04/09/2025
Our new review is out in Briefings in Bioinformatics Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world @ccwendling.bsky.social @marievasse.bsky.social @sebwielgoss.bsky.social @oxunipress.bsky.social doi.org/10.1093/bib/...
doi.org
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Abstract. The increasing interest in finding new viruses within (meta)genomic datasets has fueled the development of computational tools for virus detectio
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