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Sébastien Poulin

@sebpoule.bsky.social
4.4K followers 1.3K following 1.5K posts

Medical microbiologist & Infectious diseases MD @ St-Jérôme & Montréal, Québec, 🇨🇦 🔝 Interests HBV HDV HIV & General I.D. French 🇨🇦 with a 💩 accent #IDsky #HIVsky #Medsky

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Sébastien Poulin @sebpoule.bsky.social · 24/09/2026
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Sébastien Poulin @sebpoule.bsky.social · 23/09/2026
Great, but good luck trying that in Quebec, Canada, anywhere except Montreal 🤪 (live in suburbs)
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Sébastien Poulin @sebpoule.bsky.social · 23/09/2026
2026 Hyundai IONIQ 5 Preferred Long Range AWD with Ultimate Package White matte (and same thing for my wife lol, we call them our “twins”)
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Sébastien Poulin @sebpoule.bsky.social · 22/09/2026
On this day, at the age of 42yo, Sept 22 2026, my last gas⛽️ 🚗 refill ever. Moving to electric car. Feels good.
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Sébastien Poulin @sebpoule.bsky.social · 20/09/2026
static.klipy.com
Man Making It Rain with Money
ALT: Man Making It Rain with Money
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Sébastien Poulin @sebpoule.bsky.social · 20/09/2026
Exactly. And as soon as it’s available, people will start to use it for whatever reasons (99% not good ones). That’s why I’m against it 100%
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Sébastien Poulin @sebpoule.bsky.social · 20/09/2026
Not available here And I don’t want it
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Sébastien Poulin @sebpoule.bsky.social · 20/09/2026
Pro tip; Stop using “reply all” email to confirm an abstract review if you didn’t change anything.
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Reposted by Sébastien Poulin
Ilan Schwartz @germhuntermd.bsky.social · 17/09/2026
Less is more, ortho-ID edition Another game changer in ortho ID from the group that brought you OVIVA Pts with ortho infections who underwent curative surgery (no DAIR) with local implantation of abx were randomized to <=7d vs >=4w ABx No Dif in 12 mo relapse www.nejm.org/doi/full/10.... #IDSky
Forest plot with primary analysis results which shows no difference in definite treatment failure, definite/probable treatment failure, or definite/probable/possible treatment failure according to treatment durationForest plot showing subgroup analysis which shows no difference between shorter and longer duration antibiotics in any of the subgroups including prosthetic infection, Staph aureus mono infection, and whether local gentamicin was used in mono therapy or combination therapy
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Sébastien Poulin @sebpoule.bsky.social · 16/09/2026
Im from 🇨🇦 and using Roon 🙃
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Sébastien Poulin @sebpoule.bsky.social · 13/09/2026
oh wow, hard to find indeed haha thank you
static.klipy.com
Ken Jeong (Ben Chang) Says 'So Tiny'
ALT: Ken Jeong (Ben Chang) Says 'So Tiny'
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Sébastien Poulin @sebpoule.bsky.social · 13/09/2026
Why no pdf ?
static.klipy.com
Confused White Cat Asks Why
ALT: Confused White Cat Asks Why
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 09/09/2026
🔥🔥Back online🔥🔥 IDSA/ESCMID 2026 Guidelines on Staphylococcus aureus Bacteremia: Risk Stratification, Diagnostic Evaluation, and Management of Adults and Children Part-1 #idsky www.idsociety.org/practice-gui...
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Sébastien Poulin @sebpoule.bsky.social · 08/09/2026
static.klipy.com
Ron Burgundy Say Whaaat Meme
ALT: Ron Burgundy Say Whaaat Meme
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Sébastien Poulin @sebpoule.bsky.social · 02/09/2026
Watching a @wrexhamafc.co.uk 3-0 win against Millwall (between cases at the 🏥) Go Reds Go !!! cc @josephmarcusid.medsky.social
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Reposted by Sébastien Poulin
Jonathan Ryder, MD @jonathanrydermd.bsky.social · 29/08/2026
POET II RCT is out now in @nejm.org, assessing antibiotic duration in endocarditis! "Response-tailored" vs standard durations in Staph, Strep & Enterococci n=502 Response tailored with 13d less antibiotics, similar composite safety but higher relapse #IDSky www.nejm.org/doi/abs/10.1...
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Sébastien Poulin @sebpoule.bsky.social · 24/08/2026
Right before a Québec election lol
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Sébastien Poulin @sebpoule.bsky.social · 24/08/2026
static.klipy.com
Tabarnak Patrick Roy
ALT: Tabarnak Patrick Roy
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IDSA @idsainfo.bsky.social · 22/08/2026
Meet the newest voices behind Let’s Talk ID! ID physicians @kcawcutt.bsky.social and @cortes-penfield.bsky.social join the podcast as co-hosts for episodes focused on research published in IDSA journals. (1/2)
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Clinical Infectious Diseases @cidjournal.bsky.social · 18/08/2026
HRA for you! HRA for you! HRA … not for you? ✅ Just Accepted ⭐ Editor's Choice 🔗 bit.ly/4wDbYls
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Sébastien Poulin @sebpoule.bsky.social · 13/08/2026
Have you ever seen a case of MRSL? Methicillin-Resistant Staphylococcus lugdunensis #IDsky n=1 yesterday for me 😵‍💫
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Sébastien Poulin @sebpoule.bsky.social · 02/08/2026
@wrexhamafc.co.uk ❤️
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Reposted by Sébastien Poulin
Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 30/07/2026
🔥🔥IDSA AMR Guidance 2026🔥🔥 🔺Notable Updates from the 2024 IDSA AMR Guidance Document 🔺Meropenem dosing update: individualized dosing approach (1–2 g IV q8h) with higher doses considered in selected clinical scenarios. #idsky www.idsociety.org/practice-gui...
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Sébastien Poulin @sebpoule.bsky.social · 16/07/2026
A dream come true Visit of Wrexham 🏴󠁧󠁢󠁷󠁬󠁳󠁿 from 🇨🇦 @wrexhamafc.co.uk @vancityreynolds.bsky.social
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Sébastien Poulin @sebpoule.bsky.social · 14/07/2026
Source control > antibiotics since 1270 #NorthWalesTours #IDsky
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Sébastien Poulin @sebpoule.bsky.social · 10/07/2026
Walking in London #penicillin
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Sébastien Poulin @sebpoule.bsky.social · 08/07/2026
p.s. Two 🇨🇦 @wrexhamafc.co.uk fans in the family
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Sébastien Poulin @sebpoule.bsky.social · 08/07/2026
My best Strava activity so far
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Sébastien Poulin @sebpoule.bsky.social · 06/07/2026
👇
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Sébastien Poulin @sebpoule.bsky.social · 19/06/2026
Well, it finally happened. My first awkward Zoom moment. I was watching a pan-🇨🇦 post EASL meeting presentation (by CASL). I forgot to close my camera. I ended up bare chest while preparing a workout at home… in front of the « crowd » . 🤪😅🤦‍♂️🤷‍♂️
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Sébastien Poulin @sebpoule.bsky.social · 17/06/2026
and Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial @thelancet.com #IDsky www.sciencedirect.com/science/arti...
sciencedirect.com
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 17/06/2026
🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
nejm.org
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia | NEJM
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...
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The Journal of Infectious Diseases @jidjournal.bsky.social · 10/06/2026
Concomitant liver steatosis in chronic HBV infection is linked to a distinct cytokine profile and reduced viral load ✅ Just Accepted 🔗 bit.ly/4ejsct3
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
This was an incredible collaboration between Johns Hopkins Division of Infectious Diseases, University of Toronto, NIH, and Aarhus University. Thanks to the Hopkins CFAR, the Ontario HIV Treatment Network and the W.W. Smith Charitable Trust for funding this study.
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
You can find the paper here rdcu.be/fm8lU We hope this study will improve the care of people with HIV with detectable viremia on ART and provide a new tool to study HIV persistence.
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
➡️We observed a progressive increase in 5'L-defective RNA in plasma from 1 month on ART (~1%) to long-term ART (~95%), suggesting differential selective pressure for 5'L-defective proviruses.
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
➡️We developed a digital PCR assay allowing to easily Capture 5'Leader Anomalies Without Sequencing (🦀CLAWS🦀). CLAWS is a "drop-off" dPCR assay that can distinguish intact from mutated or deleted Major Splicing Donor (MSD) sequences, where 5'Leader defects converge.
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
➡️NSV during long-term ART is most likely caused by 5'Leader defective virus released from infected clones, extending previous work from our group and others.
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
We studied ~50 PWH on ART with detectable viremia despite no drug resistance and optimal adherence to investigate the frequency of defective proviruses contributing to HIV in plasma. Three take home messages:
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Sébastien Poulin @sebpoule.bsky.social · 09/06/2026
Important #HIV work by @frsimonetti.bsky.social and team. Here's a post by Dr Simonetti on LinkedIn👇 #IDsky ________________________________________ 🦀Time to celebrate🦀. Our study on #HIV non-suppressible viremia despite effective ART has been published in Nature Portfolio (Nat Comm).
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Sébastien Poulin @sebpoule.bsky.social · 07/06/2026
Cancelled; Studies of Oral Weekly Lepetegravir (Formerly GS-1720) and Lenacapavir Pacfosacil (Formerly GS-4182); WONDERS-1 and WONDERS-2 ⬇️CD4 I won’t lie; I completely missed that. #IDsky #HIVsky www.fiercebiotech.com/biotech/gile...
fiercebiotech.com
Gilead cancels midstage HIV trial as FDA’s clinical hold remains intact
After the FDA placed two of its next-gen HIV drugs on clinical hold last June, Gilead Sciences has now terminated one of the affected trials. | After the FDA placed two of its next-gen HIV drugs on cl...
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Sébastien Poulin @sebpoule.bsky.social · 29/05/2026
#EASL2026 «For the very first time in history, you saw a phase 3 trial with the endpoint S antigen (HBsAg) loss» -Dr @heinerwedemeyer.bsky.social about HBV B-Well phase 3 trials #IDsky
static.klipy.com
Lance Geiger: That Is History!
ALT: Lance Geiger: That Is History!
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Sébastien Poulin @sebpoule.bsky.social · 28/05/2026
HBV Functional cure with Bepirovirsen B-Well 1 and B-Well 2 phase 3 studies ➡️ 24 weeks of Bepi s/c q1 week (all on NUCs) ~19% if qHBsAg <3000 ~26% if qHBsAg <1000 #EASL2026 #IDsky
nejm.org
Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection | NEJM
Treatment with bepirovirsen, an antisense oligonucleotide targeting hepatitis B virus (HBV) transcripts, has the potential to result in a functional cure, defined by at least 24 weeks of a sustaine...
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Reposted by Sébastien Poulin
Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 27/05/2026
🆕💥🔴Don’t Drop the B: Risk of Hepatitis B Virus Infection and Reactivation in the Era of Tenofovir-Sparing Regimens for Treatment and Prevention of HIV #idsky academic.oup.com/cid/article-...
academic.oup.com
Don’t Drop the B: Risk of Hepatitis B Virus Infection and Reactivation in the Era of Tenofovir-Sparing Regimens for Treatment and Prevention of HIV
Abstracts. Tenofovir-sparing antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) are increasingly used.
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Sébastien Poulin @sebpoule.bsky.social · 27/05/2026
Top 20 Greatest Hits in HIV Medicine; Thank you Dr @paulsaxmd.bsky.social for your great Montreal 🇨🇦 presentation (special bonus; picture of young Dr Sax and colleagues)
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Sébastien Poulin @sebpoule.bsky.social · 03/05/2026
media.tenor.com
a picture of a mountain with the words coucou written on it
ALT: a picture of a mountain with the words coucou written on it
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Sébastien Poulin @sebpoule.bsky.social · 30/04/2026
Long time no see #IDsky Petechial hemorrhage in the palpebral conjunctiva of the lower eyelid … ❤️‍🩹Endocarditis (shared with patient consent)
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Sébastien Poulin @sebpoule.bsky.social · 25/04/2026
and don’t forget the nurses « 🤩 faces » that you get with Cefazolin q8h instead of Cloxa q4h 😉😅😉
media.tenor.com
a man says " it 's definitely worth it " in front of a gaming chair
ALT: a man says " it 's definitely worth it " in front of a gaming chair
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Sébastien Poulin @sebpoule.bsky.social · 25/04/2026
I believe you. It’s possible. But in my own 11 y of practice, I have seen many AKI requiring management with IV Cloxacillin. Same for my colleagues. (But we should use RCT results instead of our experience) p.s. I’m pretty sure in 🇨🇦 the $ favors Cefazolin when we include nurse / pharmacy time etc
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Sébastien Poulin @sebpoule.bsky.social · 25/04/2026
💯 %
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