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Sophie Desgraupes

@sdesgraupes.bsky.social
72 followers 65 following 3 posts

Postdoctoral fellow in Arhel lab at IRIM institute, studying the role of RanBP2 in acute necrotizing encephalopathy following IAV infection 🦠🧬

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Sophie Desgraupes @sdesgraupes.bsky.social · 02/03/2026
After 3 years, I’m very happy to share my postdoc work which has been published in @natcomms.nature.com 🎉 doi.org/10.1038/s414... ✨ Thank you @arhelnathalie.bsky.social for your guidance and support ! #influenza #NPC #RANBP2 #Nup358 #Inflammation #ANE #AcuteNecrotizingEncephalopathy #virology
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Reposted by Sophie Desgraupes
Nathalie J Arhel @arhelnathalie.bsky.social · 29/09/2025
RANBP2 is a major susceptibility factor in Acute Necrotizing Encephalopathy. But is it a single protein, or are there other isoforms with distinct roles we should be studying? @sdesgraupes.bsky.social @aneinternational.bsky.social @irim-life.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Unravelling the diversity of RANBP2: protein isoforms and implications for cellular function and human disease
RANBP2 (also known as Nup358) is the largest nucleoporin of the nuclear pore complex (NPC), where it constitutes the main component of the cytoplasmic…
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Sophie Desgraupes @sdesgraupes.bsky.social · 27/04/2025
Super excited for the ANEmone colloque tomorrow reuniting families, clinicians and scientists in order to better understand ANE1 ! @arhelnathalie.bsky.social
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Sophie Desgraupes @sdesgraupes.bsky.social · 26/04/2025
Merci à la SFV de m’avoir permis de présenter une partie de mes travaux sur RANBP2 aux #JFV2025 ! À l’année prochaine à Toulouse !
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Nathalie J Arhel @arhelnathalie.bsky.social · 03/12/2024
Acute Necrotising Encephalopathy 1 is a rare disease that triggers devastating brain damage in young children following a viral infection. Please would you consider giving to help 19 kids with ANE1 from 🇺🇸🇨🇦🇪🇺 attend a science-patient conference in 2025 🙏 #GivingTuesday fondsguilhem.fr/projet/souti...
fondsguilhem.fr
Soutien à l'organisation d'une rencontre de patients atteints d'ANE1 - fonds guilhem
En avril prochain, cet événement aura pour but de promouvoir un partage d’expériences et d'apporter un soutien grâce à la rencontre entre familles, chercheurs et médecins autour de l'ANE1.
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Waggoner Lab @labwaggoner.bsky.social · 26/03/2025
RANBP2 regulates influenza RNA replication and nuclear export, triggering hyper-inflammation, offering insight into Acute Necrotizing Encephalopathy pathogenesis doi.org/10.1101/2025...
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 25/03/2025
The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection www.biorxiv.org/content/10.1101/202…
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Nathalie J Arhel @arhelnathalie.bsky.social · 28/03/2025
Our latest collaborative study with the Pasteur Institute and University of Toronto on the role of RANBP2 in #influenza -associated hyperinflammation #AcuteNecrotizingEncephalopathy @aneinternational.bsky.social @ribonucleicacids.bsky.social @irim-life.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection
Influenza virus infections can cause severe complications such as Acute Necrotizing Encephalopathy (ANE), which is characterised by rapid onset pathological inflammation following febrile infection. H...
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