Scripps Research scientists engineered a small protein that binds to the immune receptor TLR4 within cell membranes and reduces signals that can drive inflammation, pointing to a potential drug target for inflammatory diseases.

Gain insight into the many ways our scientists seek to protect the heart, from predicting disease onset to creating regenerative medicines.

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New findings from Scripps Research and the University of Illinois Urbana-Champaign reveal a previously unknown way that the protein transthyretin can unfold and break down, and how it may contribute to rare forms of amyloid disease.

We study addiction biology from molecules to behavior. See how we're creating safer, more effective medicines and vaccines for this chronic disorder.

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Protein dynamics in the micro-to-millisecond timescale once took months of experiments to characterize. Dyna-1 can now predict them in roughly 30 seconds.

Scripps Research scientists have developed an ECG foundation model that can be adapted to new clinical tasks with less labeled data.

In our September 9 Front Row lecture, Giordano Lippi shares what his lab is learning about the role that tiny molecules called microRNAs play in brain development. With new insights, his team is developing novel tools for potentially treating genetic disorders of the developing brain. Take a seat an…

Long Covid saps the strength and vitality of patients, who have little recourse to fight it. A team of specialists—including an afflicted researcher working mostly from her bed—is looking for answers

Scripps Research scientists used an inexpensive iron catalyst to assemble cyclopropanols one carbon at a time, giving chemists more flexible access to the functional group.

In our September 9 Front Row lecture, Giordano Lippi shares what his lab is learning about the role that tiny molecules called microRNAs play in brain development. With new insights, his team is developing novel tools for potentially treating genetic disorders of the developing brain. Take a seat an…

The relationships built during graduate school often continue to shape careers long after a degree is earned, creating a community of scientists who learn from one another across generations. For Scripps Research alumnus Greg Tabor, who earned his PhD in 2015, that sense of continuity has come full circle.

Dr. Amy Lightner has spent her career moving between the operating room and the research lab, treating ulcerative colitis (UC) and other inflammatory bowel disease (IBD) patients as a surgeon while also searching for better treatments as a scientist.

The five-year award will support fundamental research on immune cell biology, which aims to advance therapeutic strategies that harness T cell responses to prevent and treat infectious diseases.

Small molecule medicines are among the most important tools in modern medicine, treating diseases ranging from infections to cancer. Many of the most promising compounds are extraordinarily complex, h...

Scripps Research has established the Peter K. Vogt Endowed Chair, a new faculty chair honoring the impactful scientific career of Peter K. Vogt, professor emeritus in the institute's Department of Molecular and Cellular Biology.

Scripps Research scientists and collaborators show how to fine-tune molecular structures within vaccines to better protect against diseases like HIV.

Scripps Research scientists reveal how cells turn down protein production and conserve energy—a critical mechanism in aging, cancer and neurodegeneration.