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Scott Soderling

@scottsoderling.bsky.social
382 followers 202 following 52 posts

Neuroscientist-cell biologist, proteomics developer, deep learning collaborator, tackling brain disorders. PI @Duke. Chair of Cell Biology and Biochem. Founder, Triangle Protein Design. soderlinglab.cellbio.duke.edu

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Reposted by Scott Soderling
Marc Sommer @neurocircuits.bsky.social · 26/09/2026
📢 To everyone on the job market who has a vision for neuroscience applied to biomedical applications & technological innovation: The Duke Department of Biomedical Engineering announces a tenure-track faculty job search in neural engineering, broadly defined! academicjobsonline.org/ajo/jobs/32784
View of Duke Chapel looking up a quiet street framed by colorful autumn foliage
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Sergey Ovchinnikov @sokrypton.org · 15/08/2026
getting close to recreating Jane Richardson's style 😎
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John Pearson @jmxpearson.bsky.social · 28/07/2026
**Four** positions in AI/ML for biology at @dukemedschool.bsky.social, including in Neurobiology. @scottsoderling.bsky.social and David Page are leading a tremendous initiative in Discovery AI. Wonderful colleagues, wonderful place.
nature.com
AI/ML for Biology - 4 tenure-track assistant professor positions - Durham, North Carolina job with Duke University - Biochemistry & Cell Biology | 12862109
Discovery AI Initiative and Departments of Biochemistry and Cell Biology, Integrative Immunobiology, Neurobiology, and Pharmacology & Cancer Biology
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Scott Soderling @scottsoderling.bsky.social · 11/06/2026
Funny quote of the day. “No major life decisions within 30 days of: A meditation retreat A psychedelic experience Your first encounter with the latest Claude model” 😂
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Emma Chory, Ph.D. @chorye.bsky.social · 09/06/2026
Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬 This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.
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Duke University School of Medicine @dukemedschool.bsky.social · 27/04/2026
Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment. medschool.duke.edu/news/hidden-enzy… #AcademicSky #MedSky
medschool.duke.edu
Hidden enzyme may explain muscle loss tied to cancer treatment and aging
Team from Duke University School of Medicine and Duke NUS identify an enzyme that helps explain why muscles weaken in some cancer patients.
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Reposted by Scott Soderling
Jason Shepherd @jasonsynaptic.bsky.social · 10/04/2026
It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.
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Scott Soderling @scottsoderling.bsky.social · 18/03/2026
My lab was lucky to be able to help test Proteina-Complexa binders experimentally. We were blown away by the results. Congrats to our colleagues at NVIDIA!
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Christian Dallago @machine.learning.bio · 26/02/2026
Find out more: flip.protein.properties
flip.protein.properties
FLIP2: Expanding Protein Fitness Landscape Benchmarks
FLIP2: A comprehensive benchmark for protein fitness prediction with 7 datasets, 16 splits, and real-world engineering scenarios
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Christian Dallago @machine.learning.bio · 22/12/2025
You can use the model right now to freely generate families for single sequence inputs (i.e., diversification conditioned by intrinsic representations of evolution), or to engineer proteins based on family promts (diversification by conditioning on particular evoluationary trajectories).
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Albert Vilella, PhD. @albertvilella.bsky.social · 15/12/2025
@rohitsingh8080.bsky.social USHER: Guiding Foundation Model Representations through Distribution Shifts Aditya Pratapa, Purushothama Rao Tata, Rohit Singh bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...
doi.org
USHER: Guiding Foundation Model Representations through Distribution Shifts
Foundation models pre-trained on certain biological data modalities exhibit systematic representational biases when encountering out-of-distribution (OOD) data from new assays. The embedding drift lar...
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Yudong Gao @yudonggao.bsky.social · 03/12/2025
The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!
nature.com
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
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Scott Soderling @scottsoderling.bsky.social · 04/12/2025
There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab! www.nature.com/articles/s41...
nature.com
A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications
The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...
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Scott Soderling @scottsoderling.bsky.social · 03/11/2025
Sounds very exciting
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Katie Tschida @katietschida.bsky.social · 03/11/2025
The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour! authors.elsevier.com/a/1m1YDmjMA4GP bsky.app/profile/kati...
authors.elsevier.com
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Scott Soderling @scottsoderling.bsky.social · 27/10/2025
Deadline for applications- November 1st!
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Stefano Di Talia @ditalialab.bsky.social · 25/10/2025
We are hiring!
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Scott Soderling @scottsoderling.bsky.social · 25/10/2025
Please repost!!: We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!! www.nature.com/naturecareer...
nature.com
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591
Tenure-Track Assistant Professor Position –AI/ML for Cell Biology
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Debby Silver @debbysilver.bsky.social · 10/10/2025
I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
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Scott Soderling @scottsoderling.bsky.social · 08/10/2025
Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon! www.biorxiv.org/content/10.1...
biorxiv.org
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John Pearson @jmxpearson.bsky.social · 07/09/2025
Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be. academicjobsonline.org/ajo/jobs/30509
academicjobsonline.org
Duke University, Cell Biology/Duke University Medical Center
Job #AJO30509, 24903 Tenure - Track Assistant Professor Position - AI/ML for Biology, Cell Biology/Duke University Medical Center, Duke University, Durham, North Carolina, US
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Scott Soderling @scottsoderling.bsky.social · 07/09/2025
Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509 #hiring #AIforBio #CompBio
“Duke University School of Medicine” logo above a line with “Discovery AI” logo
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Priyom Adhyapok @priyomadhyapok.bsky.social · 02/09/2025
Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...) Additional thread below
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Stefano Di Talia @ditalialab.bsky.social · 02/09/2025
Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!
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Duke University School of Medicine @dukemedschool.bsky.social · 20/08/2025
Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA). 🔗: mgm.duke.edu/news/fundamental-cell-… #AcademicSky #MedSky
mgm.duke.edu
Fundamental Cell Molecule Could Help Fight Rare Brain Disorders | Duke Department of Molecular Genetics and Microbiology
Duke researchers may have found a path to treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA).  People with NBIA have extra iron accumulation ...
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Scott Soderling @scottsoderling.bsky.social · 18/08/2025
Another milestone for the amazing Munjal lab!
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Nature @nature.com · 11/08/2025
The order is the latest move by the Trump administration to assert control over US science go.nature.com/3H6IxVr
go.nature.com
Trump order gives political appointees vast powers over research grants
Researchers are alarmed that the move might upend a long-standing tradition of peer-review for grants.
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Debby Silver @debbysilver.bsky.social · 10/08/2025
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
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Scott Soderling @scottsoderling.bsky.social · 07/08/2025
Great work from Huanghe Yang’s lab in Duke Biochemistry.
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Scott Soderling @scottsoderling.bsky.social · 29/07/2025
Congrats James! Loved hearing about this at an earlier CZI meeting!
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Scott Soderling @scottsoderling.bsky.social · 12/07/2025
I like o3 pro even better.
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Albert Vilella, PhD. @albertvilella.bsky.social · 11/07/2025
Steve Jobs was a vibe coder, he just prompted Steve Wozniak
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Nature @nature.com · 11/07/2025
Researchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels go.nature.com/4nNF3ri
go.nature.com
Mini hearts, lungs and livers made in lab now grow their own blood vessels
These sophisticated models will be used for human-development studies and drug testing.
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Duke University School of Medicine @dukemedschool.bsky.social · 10/07/2025
The new Center of Excellence for Multiscale Immune Systems Modeling (MISM), launching soon by Duke University School of Medicine researchers, will transform how we understand and treat infectious and immune-related diseases. #AcademicSky #MedSky
medschool.duke.edu
A New Hub for Fighting Infectious Diseases with Smarter Models
Duke University School of Medicine researchers will launch a new national Center of Excellence for Multiscale Immune Systems Modeling (MISM), funded by a U54 grant from the National Institutes of Heal...
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Scott Soderling @scottsoderling.bsky.social · 04/07/2025
Lab backpacking trip recently along the AT in NC. It's so nice to get away from it all, together.
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Rick Huganir @rhuganir.bsky.social · 30/06/2025
In this essay in Hopkins Magazine, I talk about how NIH budget cuts will delay or stop the translation of basic science to the clinic and impact kids with intellectual disability, autism, and epilepsy. hub.jhu.edu/magazine/202...
hub.jhu.edu
Research funding cuts: What's at stake
Researchers like Richard Huganir are closing in on a cure for SYNGAP1-related disorders. But in the face of federal funding cuts, can they finish what they started?
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Scott Soderling @scottsoderling.bsky.social · 25/06/2025
corporate.dukehealth.org/news/duke-un...
corporate.dukehealth.org
Duke University Sets New National Standard for Safe, Scalable AI in Health Care
DURHAM, N.C. — Duke University School of Medicine researchers have developed two pioneering frameworks designed to evaluate the performance, safety, and reliability of large-language models in health ...
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Scott Soderling @scottsoderling.bsky.social · 24/06/2025
AI research in collaboration with cell biologists is transforming research at Duke. More discoveries coming soon!!
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Duke University School of Medicine @dukemedschool.bsky.social · 24/06/2025
The AI tool Raygun (named as an homage to “Honey, I Shrunk the Kids”) is just one of several tools that a team led by Duke's Rohit Singh, PhD, has built to help scientists work both faster and smarter. 🔗 Read more: medschool.duke.edu/stories/hone... #DukeB&B #DukeCellBiology #AcademicSky #MedSky
a group of people inside of a lab, huddled around a computer
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HHMI @hhmi-science.bsky.social · 20/06/2025
Congrats to HHMI Freeman Hrabowski Scholars @channyskye.bsky.social , Josefina del Mármol (@delmarmollab.bsky.social), @yvetteefisher.bsky.social and Theanne Griffith (@doctheagrif.bsky.social), named 2025 McKnight Scholars for their demonstrated commitment to neuroscience & mentoring others! 🌟
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Chantell Evans @channyskye.bsky.social · 20/06/2025
Excited to be joining a fantastic community of neuroscientists!
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Duke University School of Medicine @dukemedschool.bsky.social · 20/06/2025
Shuo Han, PhD, a Duke biochemist, is leading research to decode the gut microbiome’s chemical language. Her lab has released a free protocol that helps researchers detect over 800 gut-derived metabolites. 🔗 Read more: www.biochem.duke.edu/news/secret-... #DukeBiochemistry #AcademicSky #MedSky
a person in a lab coat sitting in a lab
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Scott Soderling @scottsoderling.bsky.social · 16/06/2025
Looking forward to reading this.
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Yulong Li Lab @yulonglilab.bsky.social · 06/06/2025
Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...
science.org
In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors
Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...
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Swapna Krishna @swapnakrishna.com · 01/06/2025
Aurora alert! It’s possible the aurora boralis may be visible tonight as far south as Alabama. Start looking tonight after dark around 10 pm (I’ve attached both the NOAA and University of Alaska maps, the former is always very conservative with view lines) www.swpc.noaa.gov/communities/...
noaa map showing view line to PAFairbanks map showing view line into FL)
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Joris de Wit @synapse-lab.bsky.social · 08/04/2025
Postdoc opportunity in the heart of Europe! Check out the flyer below. Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
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John Yates @jyates.bsky.social · 30/05/2025
The unintended consequence of….. www.nytimes.com/2025/05/30/o...
nytimes.com
Opinion | The U.S. Deported This Chinese Scientist, in a Decision That Changed World History
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Scott Soderling @scottsoderling.bsky.social · 24/05/2025
www.theatlantic.com/magazine/arc...
theatlantic.com
What Is Academic Freedom?
A letter from an alumnus
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Joris de Wit @synapse-lab.bsky.social · 20/05/2025
Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism. authors.elsevier.com/a/1l7HS5Sx5g... Work from Ben Verpoort and colleagues, with special thanks to our collaborators.
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Scott Soderling @scottsoderling.bsky.social · 14/05/2025
🧠 New in Nature from the fabulous Silver Lab @ Duke: A human-specific enhancer, HARE5, boosts radial glia proliferation, expanding neocortical size and connectivity. Knock-in mice showed enlarged cortices and more neurons. This highlights how regulatory DNA changes shaped human brain evolution.
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