Reposted by Scott SoderlingMarc Sommer @neurocircuits.bsky.social · 26/09/2026📢 To everyone on the job market who has a vision for neuroscience applied to biomedical applications & technological innovation: The Duke Department of Biomedical Engineering announces a tenure-track faculty job search in neural engineering, broadly defined! academicjobsonline.org/ajo/jobs/32784 03116
Reposted by Scott SoderlingSergey Ovchinnikov @sokrypton.org · 15/08/2026getting close to recreating Jane Richardson's style 😎 412315
Reposted by Scott SoderlingJohn Pearson @jmxpearson.bsky.social · 28/07/2026**Four** positions in AI/ML for biology at @dukemedschool.bsky.social, including in Neurobiology. @scottsoderling.bsky.social and David Page are leading a tremendous initiative in Discovery AI. Wonderful colleagues, wonderful place.nature.comAI/ML for Biology - 4 tenure-track assistant professor positions - Durham, North Carolina job with Duke University - Biochemistry & Cell Biology | 12862109Discovery AI Initiative and Departments of Biochemistry and Cell Biology, Integrative Immunobiology, Neurobiology, and Pharmacology & Cancer Biology 11922
Scott Soderling @scottsoderling.bsky.social · 11/06/2026Funny quote of the day. “No major life decisions within 30 days of: A meditation retreat A psychedelic experience Your first encounter with the latest Claude model” 😂 110
Reposted by Scott SoderlingEmma Chory, Ph.D. @chorye.bsky.social · 09/06/2026Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬 This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution. 1134
Reposted by Scott SoderlingDuke University School of Medicine @dukemedschool.bsky.social · 27/04/2026Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment. medschool.duke.edu/news/hidden-enzy… #AcademicSky #MedSkymedschool.duke.eduHidden enzyme may explain muscle loss tied to cancer treatment and agingTeam from Duke University School of Medicine and Duke NUS identify an enzyme that helps explain why muscles weaken in some cancer patients. 022
Reposted by Scott SoderlingJason Shepherd @jasonsynaptic.bsky.social · 10/04/2026It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise. 417343
Scott Soderling @scottsoderling.bsky.social · 18/03/2026My lab was lucky to be able to help test Proteina-Complexa binders experimentally. We were blown away by the results. Congrats to our colleagues at NVIDIA! 061
Reposted by Scott SoderlingChristian Dallago @machine.learning.bio · 26/02/2026Find out more: flip.protein.propertiesflip.protein.propertiesFLIP2: Expanding Protein Fitness Landscape BenchmarksFLIP2: A comprehensive benchmark for protein fitness prediction with 7 datasets, 16 splits, and real-world engineering scenarios 021
Reposted by Scott SoderlingChristian Dallago @machine.learning.bio · 22/12/2025You can use the model right now to freely generate families for single sequence inputs (i.e., diversification conditioned by intrinsic representations of evolution), or to engineer proteins based on family promts (diversification by conditioning on particular evoluationary trajectories). 011
Reposted by Scott SoderlingAlbert Vilella, PhD. @albertvilella.bsky.social · 15/12/2025@rohitsingh8080.bsky.social USHER: Guiding Foundation Model Representations through Distribution Shifts Aditya Pratapa, Purushothama Rao Tata, Rohit Singh bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...doi.orgUSHER: Guiding Foundation Model Representations through Distribution ShiftsFoundation models pre-trained on certain biological data modalities exhibit systematic representational biases when encountering out-of-distribution (OOD) data from new assays. The embedding drift lar... 063
Reposted by Scott SoderlingYudong Gao @yudonggao.bsky.social · 03/12/2025The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!nature.comA distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature CommunicationsThe existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to... 392
Scott Soderling @scottsoderling.bsky.social · 04/12/2025There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab! www.nature.com/articles/s41...nature.comA distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature CommunicationsThe existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to... 0140
Reposted by Scott SoderlingKatie Tschida @katietschida.bsky.social · 03/11/2025The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour! authors.elsevier.com/a/1m1YDmjMA4GP bsky.app/profile/kati...authors.elsevier.com 0185
Scott Soderling @scottsoderling.bsky.social · 25/10/2025Please repost!!: We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!! www.nature.com/naturecareer...nature.comTenure-Track Assistant Professor Position –AI/ML for Cell Biology - Durham, North Carolina (US) job with Duke University School of Medicine | 12844591Tenure-Track Assistant Professor Position –AI/ML for Cell Biology 096
Reposted by Scott SoderlingDebby Silver @debbysilver.bsky.social · 10/10/2025I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1... 47524
Scott Soderling @scottsoderling.bsky.social · 08/10/2025Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon! www.biorxiv.org/content/10.1...biorxiv.org 000
Reposted by Scott SoderlingJohn Pearson @jmxpearson.bsky.social · 07/09/2025Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be. academicjobsonline.org/ajo/jobs/30509academicjobsonline.orgDuke University, Cell Biology/Duke University Medical Center Job #AJO30509, 24903 Tenure - Track Assistant Professor Position - AI/ML for Biology, Cell Biology/Duke University Medical Center, Duke University, Durham, North Carolina, US 01820
Scott Soderling @scottsoderling.bsky.social · 07/09/2025Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509 #hiring #AIforBio #CompBio 033
Reposted by Scott SoderlingPriyom Adhyapok @priyomadhyapok.bsky.social · 02/09/2025Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...) Additional thread below 2144
Reposted by Scott SoderlingStefano Di Talia @ditalialab.bsky.social · 02/09/2025Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers! 0217
Reposted by Scott SoderlingDuke University School of Medicine @dukemedschool.bsky.social · 20/08/2025Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA). 🔗: mgm.duke.edu/news/fundamental-cell-… #AcademicSky #MedSkymgm.duke.eduFundamental Cell Molecule Could Help Fight Rare Brain Disorders | Duke Department of Molecular Genetics and MicrobiologyDuke researchers may have found a path to treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA). People with NBIA have extra iron accumulation ... 052
Scott Soderling @scottsoderling.bsky.social · 18/08/2025Another milestone for the amazing Munjal lab! 030
Reposted by Scott SoderlingNature @nature.com · 11/08/2025The order is the latest move by the Trump administration to assert control over US science go.nature.com/3H6IxVrgo.nature.comTrump order gives political appointees vast powers over research grantsResearchers are alarmed that the move might upend a long-standing tradition of peer-review for grants. 25623
Reposted by Scott SoderlingDebby Silver @debbysilver.bsky.social · 10/08/2025Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/... 19234
Scott Soderling @scottsoderling.bsky.social · 07/08/2025Great work from Huanghe Yang’s lab in Duke Biochemistry. 140
Scott Soderling @scottsoderling.bsky.social · 29/07/2025Congrats James! Loved hearing about this at an earlier CZI meeting! 010
Reposted by Scott SoderlingAlbert Vilella, PhD. @albertvilella.bsky.social · 11/07/2025Steve Jobs was a vibe coder, he just prompted Steve Wozniak 0273
Reposted by Scott SoderlingNature @nature.com · 11/07/2025Researchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels go.nature.com/4nNF3rigo.nature.comMini hearts, lungs and livers made in lab now grow their own blood vesselsThese sophisticated models will be used for human-development studies and drug testing. 15515
Reposted by Scott SoderlingDuke University School of Medicine @dukemedschool.bsky.social · 10/07/2025The new Center of Excellence for Multiscale Immune Systems Modeling (MISM), launching soon by Duke University School of Medicine researchers, will transform how we understand and treat infectious and immune-related diseases. #AcademicSky #MedSkymedschool.duke.eduA New Hub for Fighting Infectious Diseases with Smarter ModelsDuke University School of Medicine researchers will launch a new national Center of Excellence for Multiscale Immune Systems Modeling (MISM), funded by a U54 grant from the National Institutes of Heal... 021
Scott Soderling @scottsoderling.bsky.social · 04/07/2025Lab backpacking trip recently along the AT in NC. It's so nice to get away from it all, together. 0111
Reposted by Scott SoderlingRick Huganir @rhuganir.bsky.social · 30/06/2025In this essay in Hopkins Magazine, I talk about how NIH budget cuts will delay or stop the translation of basic science to the clinic and impact kids with intellectual disability, autism, and epilepsy. hub.jhu.edu/magazine/202...hub.jhu.eduResearch funding cuts: What's at stakeResearchers like Richard Huganir are closing in on a cure for SYNGAP1-related disorders. But in the face of federal funding cuts, can they finish what they started? 13619
Scott Soderling @scottsoderling.bsky.social · 25/06/2025corporate.dukehealth.org/news/duke-un...corporate.dukehealth.orgDuke University Sets New National Standard for Safe, Scalable AI in Health CareDURHAM, N.C. — Duke University School of Medicine researchers have developed two pioneering frameworks designed to evaluate the performance, safety, and reliability of large-language models in health ... 010
Scott Soderling @scottsoderling.bsky.social · 24/06/2025AI research in collaboration with cell biologists is transforming research at Duke. More discoveries coming soon!! 010
Reposted by Scott SoderlingDuke University School of Medicine @dukemedschool.bsky.social · 24/06/2025The AI tool Raygun (named as an homage to “Honey, I Shrunk the Kids”) is just one of several tools that a team led by Duke's Rohit Singh, PhD, has built to help scientists work both faster and smarter. 🔗 Read more: medschool.duke.edu/stories/hone... #DukeB&B #DukeCellBiology #AcademicSky #MedSky 012
Reposted by Scott SoderlingHHMI @hhmi-science.bsky.social · 20/06/2025Congrats to HHMI Freeman Hrabowski Scholars @channyskye.bsky.social , Josefina del Mármol (@delmarmollab.bsky.social), @yvetteefisher.bsky.social and Theanne Griffith (@doctheagrif.bsky.social), named 2025 McKnight Scholars for their demonstrated commitment to neuroscience & mentoring others! 🌟 15312
Reposted by Scott SoderlingChantell Evans @channyskye.bsky.social · 20/06/2025Excited to be joining a fantastic community of neuroscientists! 4476
Reposted by Scott SoderlingDuke University School of Medicine @dukemedschool.bsky.social · 20/06/2025Shuo Han, PhD, a Duke biochemist, is leading research to decode the gut microbiome’s chemical language. Her lab has released a free protocol that helps researchers detect over 800 gut-derived metabolites. 🔗 Read more: www.biochem.duke.edu/news/secret-... #DukeBiochemistry #AcademicSky #MedSky 1103
Reposted by Scott SoderlingYulong Li Lab @yulonglilab.bsky.social · 06/06/2025Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...science.orgIn vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensorsDopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo... 112338
Reposted by Scott SoderlingSwapna Krishna @swapnakrishna.com · 01/06/2025Aurora alert! It’s possible the aurora boralis may be visible tonight as far south as Alabama. Start looking tonight after dark around 10 pm (I’ve attached both the NOAA and University of Alaska maps, the former is always very conservative with view lines) www.swpc.noaa.gov/communities/... 17790408
Reposted by Scott SoderlingJoris de Wit @synapse-lab.bsky.social · 08/04/2025Postdoc opportunity in the heart of Europe! Check out the flyer below. Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits. 02118
Reposted by Scott SoderlingJohn Yates @jyates.bsky.social · 30/05/2025The unintended consequence of….. www.nytimes.com/2025/05/30/o...nytimes.comOpinion | The U.S. Deported This Chinese Scientist, in a Decision That Changed World History 043
Scott Soderling @scottsoderling.bsky.social · 24/05/2025www.theatlantic.com/magazine/arc...theatlantic.comWhat Is Academic Freedom?A letter from an alumnus 000
Reposted by Scott SoderlingJoris de Wit @synapse-lab.bsky.social · 20/05/2025Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism. authors.elsevier.com/a/1l7HS5Sx5g... Work from Ben Verpoort and colleagues, with special thanks to our collaborators. 3347
Scott Soderling @scottsoderling.bsky.social · 14/05/2025🧠 New in Nature from the fabulous Silver Lab @ Duke: A human-specific enhancer, HARE5, boosts radial glia proliferation, expanding neocortical size and connectivity. Knock-in mice showed enlarged cortices and more neurons. This highlights how regulatory DNA changes shaped human brain evolution. 1144