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Simon Eickhoff

@sbe.bsky.social
3.3K followers 139 following 39 posts

News & Views on Brain mapping | Machine-Learning | Translational Neuroscience. And triathlon Director INM-7 FZ Jülich; Professor for Systems Neuroscience HHU Düsseldorf

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Simon Eickhoff @sbe.bsky.social · 13m
Warum ist es so schwer, KI fair zu gestalten? Mein Vortrag (morgen 7.10. um 14 Uhr) in Essen oder online per live-stream: lnkd.in/e9XiAS3h
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Thomas Yeo @bttyeo.bsky.social · 21/05/2026
In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N
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Leon Lotter @leondlotter.de · 06/05/2026
Hello Bluesky! Below this post, you will find all my very interesting "new paper" threads. 🤓 Note that some of these are much older than the timestamp because I rescued them from Twitter to make them accessible for everyone.
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Juergen Dukart @juergendukart.bsky.social · 10/02/2026
Despite decades of research there are still no reliable biomarkers for any of the major psychiatric diagnoses. In this now published perspective in Molecular Psychiatry we consolidate evidence from genetics, exposome and neuroimaging research on the potential reasons underlying these failures.
nature.com
The many-to-many problem of endophenotypes in psychiatry - a biological perspective - Molecular Psychiatry
Molecular Psychiatry - The many-to-many problem of endophenotypes in psychiatry - a biological perspective
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Todd Constable @toddc.bsky.social · 23/02/2026
It's important to note that when discussing brain structure-function relationships across scales, that the definition of function changes with scale. Keep it straight! @sbe.bsky.social link.springer.com/article/10.1...
link.springer.com
Anatomic & functional brain atlases: connecting functional flexibility with fixed infrastructure - Brain Structure and Function
Brain Structure and Function - Recent advancements in imaging across scales has propelled the development of anatomic brain atlases reflecting a wide range of cellular properties. It’s...
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Martin Gell @martingell.bsky.social · 11/03/2026
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10
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Center for Computational Psychiatry @sinaiccp.bsky.social · 01/12/2025
👉Up next, we are excited to welcome @sbe.bsky.social for our next CCP Speaker Series talk! Join us THIS FRIDAY, December 5th, at 1pm EST RSVP HERE for more details: docs.google.com/forms/d/e/1F...
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Amin Saberi @amnsbr.bsky.social · 14/11/2025
✨ New preprint ✨ Introducing cuBNM, a toolbox we developed to run brain simulations *much* more efficiently on GPUs 🎉🚀 Preprint: www.biorxiv.org/content/10.1... Documentation: cubnm.readthedocs.io/en/stable/ GitHub: github.com/amnsbr/cubnm 1/n 🧵
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Neurobiology of Aging @neurobiology-aging.bsky.social · 07/10/2025
✨ SHINY NEW PAPER ✨ Sleep-disordered breathing is associated with higher Aβ burden, lower rFDG, and worse cognition in Alzheimer's Disease. @sbe.bsky.social www.sciencedirect.com/science/article/pii/S0197458025001034
sciencedirect.com
How is self-reported sleep-disordered breathing linked with biomarkers of Alzheimer’s disease?
Sleep-disordered breathing (SDB) is prevalent in Alzheimer’s disease (AD). Here, we assessed how self-reported SDB is linked with AD biomarkers, inclu…
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Pascal Grumbach @pascal-grumbach.bsky.social · 17/09/2025
Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 07/09/2025
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇 www.biorxiv.org/cgi/content/...
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Meike Hettwer @meikehettwer.bsky.social · 25/08/2025
The end of a PhD journey 🎓 What a ride - full of lovely people, exciting science, coding tunnels, coffee-brainstorms & amazing conferences! Whole-hearted thank you to all who shared the journey & celebrated with me - especially @sofievalk.bsky.social, @sbe.bsky.social &@mps-cognition.bsky.social 💐🥳❤️
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Thomas Yeo @bttyeo.bsky.social · 17/07/2025
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...
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Ted Satterthwaite @ted-satterthwaite.bsky.social · 25/06/2025
Amelie Rauland (all star via IRTG student w/ @sbe.bsky.social ) will be presenting "Benchmarking Reconstruction Methods for Bundle Segmentation in Single-Shell dMRI" on Friday and Saturday, Poster #1283
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ABCD-J @abcd-j.bsky.social · 06/06/2025
#ABCD-J #Studienhighlights: Eine kürzlich erschienene Studie zeigt mittels #JTrack Social Unterschiede in Kommunikationsmustern zwischen neurotypischen Erwachsenen und Erwachsenen mit #Autismus-Spektrum-Störung auf. Neugierig geworden? Das ganze Highlight gibt es hier: www.abcd-j.de/de/showcases...
Mehrere Liniendiagramme, die die durchschnittliche tägliche Nutzungsdauer von Smartphones in verschiedenen Kommunikationskategorien zeigen. In Türkis sind jeweils die Daten der Kontrollgruppe mit typischer neurologischer Entwicklung (TD) abgebildet, und in rosa die Daten der Erwachsenen mit  Autismus-Spektrum-Störung (ASD). In der Gesamtkommunikation zeigt sich kein Unterschied zwischen den Gruppen (unterste Grafik). Die TD Gruppe nutzt jedoch mehr verbale Kommunikation als die ASD Gruppe (oberste Grafik), während die ASD Gruppe mehr schriftliche Kommunikation nutzt (zweite Grafik).
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Amin Saberi @amnsbr.bsky.social · 05/06/2025
🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️
science.org
Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling
Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.
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Boris Bernhardt @borismontreal.bsky.social · 05/06/2025
⭐ new paper Maturation of cortical excitation-inhibition (EI) in adolescence now in Science Advances 💥 A true tour de force of multimodal MRI, connectomics & GPU-powered 🤖!! biophysical modelling by hiball superheroes 🦸‍♂️🦸‍♀️🦸‍♂️ @amnsbr.bsky.social @sofievalk.bsky.social @sbe.bsky.social
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Simon Eickhoff @sbe.bsky.social · 01/05/2025
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Simon Eickhoff @sbe.bsky.social · 24/04/2025
Our #metaanalysis (n = 231) in JAMAPsych reveals consistent brain abnormalities across #sleep disorders involving affective and cognitive hubs in sgACC, amygdala/hippocampus Short-term sleep deprivation shows a distinct picture, affecting the thalamus jamanetwork.com/journals/jam...
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Thomas Yeo @bttyeo.bsky.social · 26/03/2025
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
nature.com
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications
Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.
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NeuroecologyLab @neuroecologylab.bsky.social · 18/03/2025
Always thought we should use connectivity blueprints to investigate differences between human, chimpanzee, and macaque brains? www.jneurosci.org/content/earl... For Katherine Bryant’s latest masterpiece.
jneurosci.org
Connectivity profile and function of uniquely human cortical areas
Determining the brain specializations unique to humans requires directly comparative anatomical information from other primates, especially our closest relatives. Human ( Homo sapiens ) (m/f), chimpan...
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Simon Eickhoff @sbe.bsky.social · 14/03/2025
Analysis Methods: 11:00 – 11:30 Harmonize: Leakage in data harmonization JuSpace: cross-modal brain map correlation Applied Concepts: 11:30 – 12:00 Causal modeling for Confounds in ML Subtypes of major depression
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Simon Eickhoff @sbe.bsky.social · 14/03/2025
NOW, Join if you're interessted Topic: DGKN Hackroom 2025 — Tool Talks Time: Mar 14, 2025 10:30 - 12h fz-juelich-de.zoom.us/j/6792251876... Data Management: 10:30 – 11:00 Datalad: GPDR conform collaboration Jtrack: remote wearable assessment
fz-juelich-de.zoom.us
Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
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Juergen Dukart @juergendukart.bsky.social · 12/03/2025
Now out in NPJ Digital Medicine our manuscript on real-world evidence for altered communication preferences in autism: nature.com/articles/s41... @sbe.bsky.social @leoschilbach.bsky.social
nature.com
Real world evidence for altered communication patterns in individuals with autism spectrum disorder - npj Digital Medicine
npj Digital Medicine - Real world evidence for altered communication patterns in individuals with autism spectrum disorder
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OHBM Communications Committee (ComCom) @ohbm-com.com · 06/03/2025
A new #Neurosalience episode is out! 🧠 From Big Data to Biomarkers with Peter Bandettini @fmri-today.bsky.social and Simon Eickhoff @sbe.bsky.social youtu.be/z91SiENsgF8
youtu.be
Neurosalience #S5E10 with Simon Eickhoff - From Big Data to Biomarkers
YouTube video by Organization for Human Brain Mapping
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ABCD-J @abcd-j.bsky.social · 04/03/2025
Dazu integrieren wir – das Institut für Neurowissenschaften und Medizin: Gehirn und Verhalten (INM-7) @fz-juelich.de, und unsere klinischen Partner an den Unikliniken Aachen, Bonn, Köln, und Düsseldorf – verschiedene technische Lösungen zu einer digitalen Plattform und vernetzen uns.
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Thomas Yeo @bttyeo.bsky.social · 24/01/2025
Thanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula... The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵
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Simon Eickhoff @sbe.bsky.social · 16/12/2024
Fully agreed. This adds another layer of complexity We likely need to differentiate three aspects here - "True" changes of the trait - State-changes due to, e.g., sleep - Measurement error All three can and will superimpose
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Simon Eickhoff @sbe.bsky.social · 14/12/2024
In my view, the take-home message is slightly different from the BWAS paper. The latter argued you need large N. This paper shows that if your target is unreliable, even very large numbers can’t save you Also, association vs prediction
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Simon Eickhoff @sbe.bsky.social · 13/12/2024
The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes Thought provoking work my Martin Gell et al: www.nature.com/articles/s41...
nature.com
How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications
Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...
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Simon Eickhoff @sbe.bsky.social · 03/12/2024
This is what happens if preprints are treated as „scientific literature“ Don’t get me wrong, I am all for preprinting. But unfortunately, it is often ignored that anybody can preprint anything
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INCF @incforg.bsky.social · 19/11/2024
We created a #neuroinformagical (obvs) starter pack! Let us know who else to add! #openscience #datasharing #neuroskyence 🧪 go.bsky.app/LRqnaMP
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Boris Bernhardt @borismontreal.bsky.social · 25/11/2024
woo hoo - fantastic new work from ‪@wanb.bsky.social‬ @sofievalk.bsky.social @sbe.bsky.social & many more on microstructural asymmetry now out in Nature Comms ⤵️
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Simon Eickhoff @sbe.bsky.social · 25/11/2024
Love the started-packs. What seems really missing yet is „machine-learning in Neuroimaging / brain medicine“ 🧠 If you work in that (or a related) field introduce yourself below. I will put together the list Please share widely to reach all newcomers 🙏🏽
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Simon Eickhoff @sbe.bsky.social · 25/11/2024
Looked into BlueSky a while ago… really empty at that time X becoming useless for interesting reads and discussions on science send me in a social-media hiatus Back now and excited about things to come
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Simon Eickhoff @sbe.bsky.social · 22/11/2024
🙋‍♂️🍻
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Jeremy Lefort-Besnard @jlefortbesnard.bsky.social · 27/06/2024
Useful reminders from @sbe.bsky.social about #neuroimaging analysis #reproducibility at #OHBM2024: - Different atlases lead to different connectivity matrices. - The target *massively* matters. - ML algorithms just *love* shortcuts.
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Jim Thompson @jimthommo.bsky.social · 29/08/2024
Lots to enjoy in this new paper by Sam Vickery @sbe.bsky.social and others. Brain areas in humans that show the greatest expansion from chimp -> human are the areas that are most susceptible to to the effects of aging www.science.org/doi/10.1126/...
science.org
The uniqueness of human vulnerability to brain aging in great ape evolution
Humans and chimpanzees show brain aging, while its spatial distribution relates to evolutionary expansion only in humans.
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Simon Eickhoff @sbe.bsky.social · 17/06/2024
We are looking for a community manager and development coordinator for DataLad !! The full description with contact info is at: files.inm7.de/mih/position...
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Simon Eickhoff @sbe.bsky.social · 22/02/2024
Spread the word 📣 Announcing the first BrainHack at the DGKN meeting next month !! After being a staple at OHBM, this will be the first hackroom at a German (clinical) neuroscience meeting Enjoy the spirit of open science with tutorials, hackathons and an unconference 🔜 Join us in Frankfurt
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Simon Eickhoff @sbe.bsky.social · 23/10/2023
Somehow it seems that computational models were immune to the current sample-size worries in #neuroimaging Turns out they are not 😱 DCM models and connections need 100+ subjects to give stable results New work by Alexander Silchenko & Felix Hoffstaedter: onlinelibrary.wiley.com/doi/10.1002/...
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dickretired @dickretired.bsky.social · 23/10/2023
That is a really important result. These models are being run on an n of 12 or 20.
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Simon Eickhoff @sbe.bsky.social · 23/10/2023
Somehow it seems that computational models were immune to the current sample-size worries in #neuroimaging Turns out they are not 😱 DCM models and connections need 100+ subjects to give stable results New work by Alexander Silchenko & Felix Hoffstaedter: onlinelibrary.wiley.com/doi/10.1002/...
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Simon Eickhoff @sbe.bsky.social · 21/10/2023
Ju = Jüliche 😅
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Simon Eickhoff @sbe.bsky.social · 20/10/2023
Finally in the public 🚀 JuLearn: an easy-to-use library for leakage-free evaluation and inspection of ML models JuLearn is an open-source Python library simplifying the entry into the ML world -> design & evaluate ML pipelines without encountering common pitfalls arxiv.org/abs/2310.12568
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Simon Eickhoff @sbe.bsky.social · 10/10/2023
It got a bit chilly in the end, but given that it is already mid-October… 😊
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Simon Eickhoff @sbe.bsky.social · 10/10/2023
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Simon Eickhoff @sbe.bsky.social · 02/10/2023
Fantastic but very worrisome work by Sami Hamdan: Confound removal in machine learning can itself lead to leakage -> After information about the target from the features using standard approaches you can STILL predict it well academic.oup.com/gigascience/... #neuroskyence #MLSky #neuroimaging
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Simon Eickhoff @sbe.bsky.social · 29/09/2023
Link to the paper in the final part of the thread (or rather, my moderately successful first try of a BSky thread) bsky.app/profile/sbe.... #neuroskyence #neuroimaging #PsychSky #cogpsyc #SciSky #lingsky
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