Nature Synthesis, Published online: 01 October 2026; doi:10.1038/s44160-026-01164-8An ice-mediated interfacial membrane synthesis method is reported that exploits the quasi-liquid layer on ice to form polyamide microcapsules with programmable dimensions and cargo-independent encapsulation. The resulting compartments combine broad cargo compatibility, tunable permeability and robust confinement, enabling efficient compartmentalized biocatalysis and multienzyme cascade reactions.

Metal-organic polyhedra (MOPs) are the porous molecular counterparts to metal-organic frameworks (MOFs). While mechanochemistry has been successfully applied to a wide range of MOFs, this synthetic approach has found more limited use for MOPs. Herein, two ...

New class of porous materials can trap gases and release them on command

Designed protein pockets recognize intrinsically disordered protein regions

The direct incorporation of borondipyrromethene (BODIPY) subunits into the structural backbone of covalent organic frameworks (COFs) gives facile access to porous photosensitizers but is still a chal...