iiinova — where your digital self keeps evolving

Reposted by Sarah Mackie

NEJM.org @nejm.org · 03/06/2026

Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone. Full phase 3 REPLENISH trial results: nej.md/3PvmmMO #EULAR2026

Chart from an article published in the New England Journal of Medicine showing results from a phase 3 trial of secukinumab in polymyalgia rheumatica. Two bar graphs depict sustained remission and complete sustained remission at week 52, comparing secukinumab, 300 mg (dark blue bars); secukinumab, 150 mg (light blue bars); and placebo (grey bars). Statistical significance is noted with P<0.001 for each comparison.

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Sarah Mackie @sarahlmackie.bsky.social · 26/10/2025

Like placebo responses, jet lag has multiple components, and not all of them are directly attributable to the jet

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Sarah Mackie @sarahlmackie.bsky.social · 16/10/2025

The evolution of how you learn to do things. 1990s: Ask your parents. 2000s: Internet search. 2010s: YouTube tutorials. Now: Ask the AI.

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Sarah Mackie @sarahlmackie.bsky.social · 08/10/2025

Today at work, it emerged that some of us (ok, me) had struggled to use the hospital’s new third-party app for requesting annual leave, and were thus destined to work for eternity without holiday. They promised digital innovation would cut waiting lists…

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Sarah Mackie @sarahlmackie.bsky.social · 05/10/2025

Taken yesterday on the outskirts of Leeds, about five minutes before the rain started (again).

Green space on the outskirts of Leeds. Rain is coming.

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Sarah Mackie @sarahlmackie.bsky.social · 23/09/2025

At St Pancras, the little dog in the Meeting-Place Statue has been worn bright from being patted by many people. These moments of connection matter. Work-wise, a couple of long-term projects are trundling along, and others are getting ready to go. Doors will close 30 seconds before departure!

Bronze relief from the frieze around the base of the Meeting-Place statue at St Pancras, depicting a man and a dog. The man is dark coloured, while the bronze of the dog is still bright.

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Sarah Mackie @sarahlmackie.bsky.social · 15/09/2025

Echoes of Malmö’s industrial past in Västra hamnområdet. On a Saturday morning, it was quiet and peaceful. Footpaths and waterways are threaded between old industrial buildings and modern housing blocks.

Old industrial building, with the name of the firm Kockums. It has high, arched windows: the glass reflects the modern buildings behind, and above those, the sky.

A corner of an old brick warehouse. The paint on the wall has the colours of a seascape: white-gold sky above, greenish sea below.

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Sarah Mackie @sarahlmackie.bsky.social · 08/09/2025

@nulliusinverba.bsky.social This prologue episode is absolutely fascinating. As scientists we have to be able to argue the case for new ideas, and at the same time, be able to judge them dispassionately. Psychologically, this isn’t easy, even for psychologists. podcasts.apple.com/gb/podcast/n...

podcasts.apple.com

Prologus 66: The Psychology of Controversy (E. G. Boring)

Podcast Episode · Nullius in Verba · 05/09/2025 · 1h 5m

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Sarah Mackie @sarahlmackie.bsky.social · 09/08/2025

Lights over Leeds: high rise blocks, streetlights, aeroplane, full moon.

Evening in Leeds. High rise blocks with full moon and plane overhead.

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Reposted by Sarah Mackie

@vasculitides @vasculitides.bsky.social · 23/07/2025

Late-Onset Spondylarthritis Presenting as Glucocorticoid-Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where TNF or IL-17 Blockade may have a Therapeutic Role pubmed.ncbi.nlm.nih.gov/40693392

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Reposted by Sarah Mackie

David Liew @drdavidliew.bsky.social · 23/06/2025

Why does it seem like PMR patients get stuck in situations we would never tolerate for other patients? @drceowen.bsky.social and I call out many reasons. PMR is killing them softly, and will continue to do so if collectively we neglect it. now out @thelancetrheum.bsky.social: t.co/wMOy9ZEzw4

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Reposted by Sarah Mackie

CreakyJoints® @creakyjoints.bsky.social · 01/05/2025

Great news for people living with giant cell arteritis (GCA)! The FDA has approved Upadacitinib (15 mg tablet, taken once daily) as a first-line treatment option — meaning it’s now a primary recommended way to manage GCA. Learn more: creakyjoints.org/education/gi... #GCA #VasculitisAwareness

creakyjoints.org

What Is Giant Cell Arteritis? These Are the Signs You Could Have It

Giant cell arteritis, or temporal arteritis, is an inflammatory disease that affects large blood vessels in the head. Learn about CGA symptoms & treatment.

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Sarah Mackie @sarahlmackie.bsky.social · 28/03/2025

Academic writing is, to me, like painting. First draft is the underpainting, putting in the main colour areas, then in redraft you paint over to sharpen detail. Writing clinic letters, on the other hand, is like rapid sketching - capturing the essence of a moment in time as accurately as possible.

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Reposted by Sarah Mackie

Adam Kucharski @adamjkucharski.bsky.social · 16/03/2025

Self-help books often cite population studies as evidence that you can change your life with one simple trick. X will improve your health. Y will make you more successful. But there's a crucial catch... 1/

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Reposted by Sarah Mackie

Nikhil Garg @nkgarg.bsky.social · 10/03/2025

*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...

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Reposted by Sarah Mackie

Eric Topol @erictopol.bsky.social · 20/02/2025

At @science.org today, an important new way we can make major headway into immunologic and infectious diseases. Sequencing the lymphocyte B and T cell receptors and A.I. to accurately make the diagnosis! www.science.org/doi/10.1126/science.adp2407 A seminal study by @anshulkundaje.bsky.social et al

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Sarah Mackie @sarahlmackie.bsky.social · 12/02/2025

Doing a talk on giant cell arteritis for general physicians next Tuesday, as part of a webinar on Updates in Rheumatology organised by the Royal College of Physicians. You can register for the webinar here: ow.ly/cLri50UXRCi

ow.ly

Episode 32: rheumatology | RCP Player

RCP Player offers healthcare professionals the latest medical updates through webinars, videos and podcasts. Explore our wide range of resources today.

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Sarah Mackie @sarahlmackie.bsky.social · 07/02/2025

Yesterday, I heard a talk from a health psychologist presenting “shared decision making” as a collaborative, rational process, involving patients understanding health information and weighing up options, finally choosing the option that most aligns with their values and preferences. (1/3)

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Sarah Mackie @sarahlmackie.bsky.social · 29/12/2024

Sheffield Cathedral with Christmas trees.

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Sarah Mackie @sarahlmackie.bsky.social · 03/12/2024

Which A. A. Milne poem talks about going on a quest for dragons? I asked ChatGPT. It gave me the wrong answer. When challenged on this, it admitted its error, but then combined the title of one poem with an extract of another. It still got it wrong. Correct answer in the replies!

ChatGPT discussion part 1. Me asking ChatGPT which A A Milne poem talks about going on a quest for dragons, and it claiming (incorrectly) that the answer is “Knights and Ladies.”

ChatGPT discussion part 2: ChatGPT producing the text of Knights and Ladies. No dragons in there at all.

ChatGPT discussion part 3. Me saying “ok where are the dragons” and it coming up with a new answer, also wrong (combining the title of one poem, Explained, with the text of another).

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Sarah Mackie @sarahlmackie.bsky.social · 24/11/2024

Spent a happy afternoon at a watercolour class at The Bowery. Remembered a lot that I thought I’d forgotten. Also the coffee was very good. Recommended!

My watercolour painting of a holly leaf, and also some other pieces of paper with the outcomes of colour-mixing experiments by me and others. Colours used for the holly picture: ultramarine, yellow ochre, sap green, Payne’s Grey, burnt umber, alizarin crimson hue, and dioxazine purple. All Cotman.

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Sarah Mackie @sarahlmackie.bsky.social · 23/11/2024

Oh I’m liking the scholargoggler tool! It even generates an alt-text to go with your personal word-cloud 👌

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Reposted by Sarah Mackie

Kate Oakland @kateoakland.bsky.social · 19/11/2024

There are some fantastic national audits that deliver truly unique insights into patient care and outcomes, but I’m always staggered at how much we rely on clinician good will to collect these data - the report shows that we ALREADY collect most of these data, but we store them in the wrong place..

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Reposted by Sarah Mackie

Mateusz Fafinski @calthalas.bsky.social · 13/11/2024

The greatest of all late antique Roman mosaics. The Capitoline She-Wolf and Romulus and Remus from Aldborough, North Yorkshire, 4th century. Today Leeds City Museum

A she-wolf with a grimacing smile made in mosaic stones with twins in front of her.

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Reposted by Sarah Mackie

UK Snow Map @uksnowmap.com · 17/11/2024

A quick reminder on how to contribute to uksnowmap.com ahead of any possible #uksnow tomorrow 👀 Post with the hashtag #uksnow, the first-half of your postcode, and a snow rating x/10 and help draw a real-time map of where it is snowing in the UK.

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Sarah Mackie @sarahlmackie.bsky.social · 16/11/2024

Making a rheumatology starter pack. Please comment to be added #MedSky go.bsky.app/5yrCZcH

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Sarah Mackie @sarahlmackie.bsky.social · 13/11/2024

Been reading the #SudlowReview on the health data landscape from a research data sharing perspective. Here are some of the topics covered and my thoughts. Full Sudlow Review: www.hdruk.ac.uk/helping-with... Thread: 🧵

hdruk.ac.uk

The Sudlow Review

'Uniting the UK’s Health Data: A Huge Opportunity for Society' is an independent review commissioned by the Chief Medical Officer for England, the UK National Statistician and NHS England’s National D...

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Reposted by Sarah Mackie

Kathleen Bachynski @bachynski.bsky.social · 23/02/2024

This is very accurate

A musical score titled “every zoom call ever“ by the London incidental orchestra

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Sarah Mackie @sarahlmackie.bsky.social · 27/10/2024

Interests: rheumatology, aging, academia, clinical trials, causal inference, uses of health data, patient involvement, vascular physiology, philosophy, endocrinology, neuroscience, academic publishing, and the weather. I have found that only the weather is any good as a topic for small-talk.

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