Sign in

Dr Samuel J Pearce

@samueljpearce.bsky.social
173 followers 455 following 29 posts

Veterinarian | Resident in Veterinary Microbiology | PhD Candidate | VetMicro.com Creator and Writer | Passionate about AMR, One Health, infectious disease and acute medicine

PostsRepliesMedia
Dr Samuel J Pearce @samueljpearce.bsky.social · 29/06/2026
You may have seen my substack posts on veterinary antimicrobial a while back... well VetMicro.com has been born! A dedicated website for antimicrobial stewardship and infectious disease education. It's early days but some exciting stuff is coming! #VetMicro #VetCMID #VetMed #VeterinaryMedicine
vetmicro.com
VetMicro | Veterinary Infectious Disease Info – Join Now
VetMicro is an educational hub for veterinary infectious disease, diagnostics, and treatment guidance to enhance antibiotic stewardship.
210
Dr Samuel J Pearce @samueljpearce.bsky.social · 26/06/2026
Hank Green's commentary on the scientific paper touches on a lot of what academics find frustrating about the 'scientific paper' (www.youtube.com/watch?v=YDfs...) @hankgreen.bsky.social maybe you should chat to @octopus-ac.bsky.social to see how they view scientific publishing of the future
youtube.com
Are Scientific Papers Bad?
YouTube video by Hank Green
101
Dr Samuel J Pearce @samueljpearce.bsky.social · 25/06/2026
An interesting, less obvious adverse effect of erratic weather and heatwaves. The article also highlights the increased use of fluids which could affect healthcare economics and sustainability 😐
010
Reposted by Dr Samuel J Pearce
Scott Weese @scottweese.bsky.social · 12/05/2026
New CDC podcast on CPE (carbapenemase-producing Enterobacterales) in animals. Unfortunately, we're going to have to deal with these highly resistant bacteria more in animals and people in coming years. tools.cdc.gov/medialibrary... www.wormsandgermsblog.com/2026/05/arti...
tools.cdc.gov
Public Health Media Library
022
Dr Samuel J Pearce @samueljpearce.bsky.social · 05/05/2026
Anyone in #IDsky know of good data on ototoxicity/nephrotoxicity of ODD gentamicin Vs amikacin? Clinical or translational! All I can find is ODD Vs MDD but often not comparing the two drugs...
000
Dr Samuel J Pearce @samueljpearce.bsky.social · 06/04/2026
Totally agree with your points and I don't think anyone has actually designed good veterinary practice software yet? Seems like every system I have used is infuriating in one way or another. Especially if you want data out for research.
010
Dr Samuel J Pearce @samueljpearce.bsky.social · 06/04/2026
Was going to say this. That tick box for bloods is now there because someone probably complained bloods weren't done after a rare unfortunate adverse event. Defensive medicine at its finest making the system worse for everyone.
000
Dr Samuel J Pearce @samueljpearce.bsky.social · 04/04/2026
The group rightly pointed out that common terminology and data sharing would facilitate One Health AMR Surveillance. Should be doing some work on this soon so keep an eye out!
041
Dr Samuel J Pearce @samueljpearce.bsky.social · 11/03/2026
If you ever want to feel like you're going insane, I highly recommend reading the methods for the UKs #AMR surveillance reports for the various monitoring programmes and trying to figure out what they're actually doing and if resistance in one even means the same thing in another 🤦
010
Dr Samuel J Pearce @samueljpearce.bsky.social · 21/11/2025
World Antimicrobial Awareness Week is nearly over, so I've been collecting resources to help vets with #AntimicrobialStewardship! #VetMed #AMR #WAAW open.substack.com/pub/resistan...
open.substack.com
Stewardship Solutions #7: World Antimicrobial Awareness Week 2025
Your definitive guide to veterinary antimicrobial stewardship!
020
Reposted by Dr Samuel J Pearce
Wellcome Sanger Institute @sangerinstitute.bsky.social · 04/11/2025
E. coli can spread as quickly as swine flu, new research reveals. 🦠 For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections. Read here ⤵️ sanger.ac.uk/news_item/ad...
sanger.ac.uk
Advanced disease modelling shows some gut bacteria can spread as rapidly as viruses
Experts can now predict the transmission rate of a bacterial E. coli infection in the same way as they can for viral pandemics, which can help battling treatment-resistant infections in the future.
1177
Dr Samuel J Pearce @samueljpearce.bsky.social · 21/10/2025
One for the surgeons today. Many vets perform surgery on a regular basis, so understanding infection prevention and antimicrobial prophylaxis is key in prevent surgical site infections and promoting responsible antimicrobial use! open.substack.com/pub/resistan...
open.substack.com
Stewardship solutions #6: Surgical solutions
All you need to know to prevent, identify and treat surgical site infections
010
Reposted by Dr Samuel J Pearce
CIDRAP @cidrap.bsky.social · 02/10/2025
Two investigations reveal how resistant bacteria may have spread from pets to people Molecular analysis and epidemiologic detective work helped uncover a hidden One Health link between human and pet clusters of multidrug-resistant bacterial infections. www.cidrap.umn.edu/a...
22514
Reposted by Dr Samuel J Pearce
Zamin Iqbal @zaminiqbal.bsky.social · 10/09/2025
Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...
nature.com
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology
LexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.
519099
Reposted by Dr Samuel J Pearce
Demetre Daskalakis @drdemetre.bsky.social · 28/08/2025
Enough is enough. The health of the country is in danger. Read our resignation letters: insidemedicine.substack.com/p/breaking-n...
insidemedicine.substack.com
Breaking News: Read three top CDC officials' resignation emails.
The end of an era.
27952252391
Dr Samuel J Pearce @samueljpearce.bsky.social · 25/08/2025
Also works for Bordatella bronchiseptica in our patients!🐕 Although I can't see it's been tested on B. pertussis in humans but other tetracyclines seem to do some good so maybe... 🤷
000
Dr Samuel J Pearce @samueljpearce.bsky.social · 20/08/2025
As someone currently writing a PhD literature review on AMR surveillance and gradually beginning to understand the wall of AMR genes in every paper I read, I wish I had a paper like this 6 months ago. Not sure I would be much help though... Yet.
020
Reposted by Dr Samuel J Pearce
The British Society for Antimicrobial Chemotherapy @bsacandjac.bsky.social · 16/07/2025
"Closure of the Fleming Fund risks undermining UK leadership on AMR." BSAC is seeking urgent clarification from the Government regarding the UK’s future leadership on antimicrobial resistance (#AMR), following reports that the Fleming Fund – the UK’s flagship global AMR programme – is set to close.
bsac.org.uk
Closure of the Fleming Fund risks undermining UK leadership on AMR - The British Society for Antimicrobial Chemotherapy
046
Reposted by Dr Samuel J Pearce
Stefan Marciniak @profmarciniak.bsky.social · 13/07/2025
‘MMR vaccination uptake rate for children by the age of five in Liverpool is just 73% ... The World Health Organisation says a threshold of 95% is needed to achieve herd immunity’ Please protect child by allowing them to be vaccinated. If you are worried, talk to your doctor. Misinformation kills.
18247
Dr Samuel J Pearce @samueljpearce.bsky.social · 08/07/2025
A couple of years ago, I bought the book Why I'm No Longer Talking to White People About Race by Reno Eddo-Lodge. I'm ashamed to say I haven't read it until now. If you haven't, I recommend you do. Today, I'm committing to monthly donations to the British Veterinary Ethnicity and Diversity Society.
vettimes.com
Racism warning as sector told to get ‘house in order’
British Veterinary Ethnicity and Diversity Society co-founder and co-author of a damning paper, Navaratnam Partheeban, says: “if we’re going to be role models f
000
Reposted by Dr Samuel J Pearce
Paolo Crosetto @paolocrosetto.bsky.social · 15/06/2025
Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model. What is going on, and why researcher will - as always - fall for it? A 🧵 the-strain-on-scientific-publishing.github.io/website/post...
the-strain-on-scientific-publishing.github.io
Springer Nature Discovers MDPI – The Strain on Scientific Publishing
Home page for the paper ‘The Strain on Scientific Publishing’ by Mark A Hanson, Dan Brockington, Paolo Crosetto and Pablo Gomez Barreiro
11251183
Reposted by Dr Samuel J Pearce
onehealthresources.bsky.social @onehealthresources.bsky.social · 13/06/2025
#OneHealthEvent One Health Investigations of Outbreaks and Spillover Events - on Coursera is a course of 10 content modules and didactic lectures. Find more: www.coursera.org/learn/one-he... #OneHealth #OneHealthResources
coursera.org
One Health Investigations of Outbreaks and Spillover Events
Offered by Johns Hopkins University. One Health is the concept that human, animal and environmental health are interconnected. Outbreaks of ... Enroll for free.
042
Reposted by Dr Samuel J Pearce
Kat Holt @katholt.bsky.social · 22/05/2025
Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight) interpretamr.github.io/AMRrules
54232
Reposted by Dr Samuel J Pearce
Pilar Garcia-Vello @pilargvello.bsky.social · 06/06/2025
The new version of R for AMR is ready! 🧫 Automated antibiograms 💻 Integration to WHONET 🧪 Updated CLSI and EUCAST breakpoints 💡 Free amr-for-r.org #biostatistics #episky #Statistics #AMR
amr-for-r.org
Antimicrobial Resistance Data Analysis
Functions to simplify and standardise antimicrobial resistance (AMR) data analysis and to work with microbial and antimicrobial properties by using evidence-based methods, as described in <doi:10.1863...
23410
Reposted by Dr Samuel J Pearce
Prof Jenny Rohn @jennyrohn.bsky.social · 21/05/2025
Absolutely thrilled to present our latest review, where we discuss how host microenvironment and bacterial subversion strategies can undermine traditional antimicrobial sensitivity testing, and whether better models may one day get us "beyond the MIC" #IDSKy rdcu.be/emYoh
rdcu.be
Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
npj Antimicrobials and Resistance - Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
3269
Dr Samuel J Pearce @samueljpearce.bsky.social · 04/05/2025
Just got back from my own Stag Do, on a beautiful bank holiday weekend, to find out that I am now officially a resident of the European College of Veterinary Microbiology!
000
Reposted by Dr Samuel J Pearce
Bradley Langford @brxad.bsky.social · 18/04/2025
🐶🐱 Companion animals need #AntimicrobialStewardship too! In our new SR/MA (led by Dr. Fiona Emdin), we examined short vs. long antibiotic durations for UTIs in dogs & cats.📉 Pooled RR for cure = 0.55 (95% CI: 0.23–1.27), very low certainty. 🔓 doi.org/10.1186/s129... More high-quality data needed!
052
Reposted by Dr Samuel J Pearce
Neil Vora, MD @conservationdoc.bsky.social · 04/04/2025
Sharing our new @thelancet.bsky.social piece on spillover prevention & #OneHealth in the WHO #PandemicAgreement. We call on states to adopt the agreement next month. Huge thanks to @alexandrafinch.bsky.social for leading this. Let's get this done and make the world a safer place! bit.ly/3E7RKeu
bit.ly
The promise and compromise of the WHO Pandemic Agreement for spillover prevention and One Health
As scientists, health professionals, and lawyers engaged in reducing pandemic spillover risks, we recognise the urgent need for, and immense potential of, a robust international agreement on pandemic ...
01110
Dr Samuel J Pearce @samueljpearce.bsky.social · 31/03/2025
Thanks for clarifying! Silly question to follow, do you use the uncomplicated UTI breakpoint for other abx for pyelo or prefer non-uti if possible? Just thinking that NICE recommendation of cefuroxime IV/co-amox PO suffers similar issues for non-uti breakpoints
000
Dr Samuel J Pearce @samueljpearce.bsky.social · 31/03/2025
This is kinda where I'm coming from too. Quinolines are favoured in VetMed and I was looking for an alternative to reduce HPCIA use. Wondered if the quinoline thing was dogma after seeing the NICE guideline but the evidence for cephs isn't helping my argument as much as I thought it would 😕
110
Dr Samuel J Pearce @samueljpearce.bsky.social · 31/03/2025
Yeah I do wonder if that's the case sometimes. What's your IV drug of choice? Cefuroxime seems to suffer the same problems but NICE has several other options
000
Dr Samuel J Pearce @samueljpearce.bsky.social · 31/03/2025
Ah my favourite podcast duo to learn AMS from the other side! I must confess, looking through that thread I realised I saw it the first time... And forgot about it 🤦 Does mean the second read was just as interesting though 😂
010
Dr Samuel J Pearce @samueljpearce.bsky.social · 30/03/2025
Sounds interesting! What dose and MIC are you using out of curiosity? This PKPD study suggests NICE doses may hit MICs anywhere from <2 to <16 (link.springer.com/article/10.1...). I will hold my hands up and say my pharmacology needs dusting off though so willing to be told otherwise 🙌
link.springer.com
A pharmacokinetic-pharmacodynamic assessment of oral antibiotics for pyelonephritis - European Journal of Clinical Microbiology & Infectious Diseases
Antibiotic resistance to oral antibiotics recommended for pyelonephritis is increasing. The objective was to determine if there is a pharmacological basis to consider alternative treatments/novel dosi...
110
Dr Samuel J Pearce @samueljpearce.bsky.social · 30/03/2025
Was thinking of a comparative article on beta-lactams use for pyelonephritis as NICE recommends PO cefalexin but upon reading the literature, I can't make it make sense 🤷 EUCAST only has a UTI breakpoint, PKPD suggests poor empirical choice, but clinical studies seem ok. Can #IDSky help me out here?
454
Dr Samuel J Pearce @samueljpearce.bsky.social · 29/03/2025
A month ago I started a fortnightly newsletter on veterinary infections disease, clinical microbiology and antimicrobial stewardship🦠This week covered some latest updates in small animal viral diseases, check it out here: open.substack.com/pub/resistan... #VetSky
open.substack.com
Stewardship solutions #3
Viral meningitis, FIP treatment durations and disinfectants for viruses
010
Reposted by Dr Samuel J Pearce
Eoghan Daltun 🌍 @irishrainforest.bsky.social · 27/03/2025
Humans are driving biodiversity loss among all species across the planet, one of the most exhaustive global studies on the subject ever conducted finds. This is *us*, people: you + me. It's up to all of us to get into the fight for the natural world. 🌏 www.theguardian.com/environment/...
theguardian.com
Biodiversity loss in all species and every ecosystem linked to humans – report
Sweeping synthesis of 2,000 global studies leaves no doubt about scale of problem and role of humans, say experts
18390158
Reposted by Dr Samuel J Pearce
Andrew Singer @oxonandrew.bsky.social · 24/03/2025
What I don’t get is why the official position continues to be… “…the risk to livestock and the general public is low.” This variant of influenza seems to infect everything…how is that a low risk? www.theguardian.com/world/2025/m...
theguardian.com
World’s first case of bird flu in sheep detected in England
H5N1 virus found in single animal in Yorkshire but risk to general public is very low, say experts
021
Dr Samuel J Pearce @samueljpearce.bsky.social · 22/03/2025
Recently, I was asked for my opinion on a novel veterinary UTI diagnostic. While the technology is fascinating, it is a good example of why sensitivity and specificity aren't always the best measure. Read more in my latest post here: resistanceisfutile.substack.com/p/sensitivit... #vetsky #IDsky
resistanceisfutile.substack.com
Sensitivity and specificity answer the wrong questions
Why how we measure a diagnostic test and how we interpret them are equally important
020
Dr Samuel J Pearce @samueljpearce.bsky.social · 21/03/2025
Was a great event! Fascinating to see so many different aspects of AMR research
010
Dr Samuel J Pearce @samueljpearce.bsky.social · 17/03/2025
Normal URL here: www.rsm.ac.uk/events/compa...
rsm.ac.uk
Challenges in human and veterinary primary care: What can we learn from the other?
This meeting aims to offer participants a dynamic conference where experts from veterinary and human health fields connect.
000
Dr Samuel J Pearce @samueljpearce.bsky.social · 17/03/2025
Interested in One Health or ever wondered what primary care is like on the other side? Check out this event from Royal Society of Medicine discussing the challenges seen in human and veterinary primary care! #MedSky #VetSky #OneHealth lnkd.in/edfazfmQ
Picture showing details for the royal society of medicine event "challenges in human and veterinary primary care: what can we learn from the other?" May 12th 2025 online
130
Reposted by Dr Samuel J Pearce
Anderson Rodrigues @amrodrigues85.bsky.social · 09/01/2025
Emerging #Sporothrix brasiliensis is fueling a cat-transmitted sporotrichosis #outbreak in Northeast Brazil. Over 1,100 cases identified in Recife's metro region (2016-2021), with zoonotic transmission linked to Rio de Janeiro strains. Link: link.springer.com/article/10.1... #PublicHealth #Zoonoses
link.springer.com
Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil - Mycopathologia
Cat-transmitted sporotrichosis is caused by the emerging fungal pathogen Sporothrix brasiliensis and constitutes a significant public health issue that affects people living in resource-poor urban cen...
0138
Reposted by Dr Samuel J Pearce
@IM_Crit_ @imcrit.bsky.social · 06/03/2025
I think one of the biggest lies we were told in medical school is that the lungs and the urinary tract are sterile... I guess lung and urinary microbiomes were not a thing yet... #meded #medsky #foamed #idsky www.nature.com/articles/nru... www.nature.com/articles/s41...
nature.com
The dynamic lung microbiome in health and disease - Nature Reviews Microbiology
Like the gut, the lung harbours a diverse, interacting assortment of microbiota. In this review, Natalini, Singh and Segal examine the role of the lung microbiome in health and disease and discuss fut...
3192
Reposted by Dr Samuel J Pearce
Antimicrobial resistance #AMR @antimicrobial.bsky.social · 06/03/2025
A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR. www.nature.com/articles/s41...
nature.com
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins&nbsp;generate defence peptides constitutively and in response to bacterial infection.&nbsp;Such peptides might provide a source of natural antibiotics that...
1437
Dr Samuel J Pearce @samueljpearce.bsky.social · 24/02/2025
Long-form articles take time. In an effort to be more active I'm introducing Stewardship Solutions, I fortnightly short articles with brief tips and info for veterinary infectious diseases and antimicrobial stewardship #VetSky #IDsky #MicroSky open.substack.com/pub/resistan...
open.substack.com
Stewardship Solutions #1
Essential updates in veterinary infectious diseases
011
Dr Samuel J Pearce @samueljpearce.bsky.social · 19/02/2025
Taking a break from antimicrobial stewardship to talk about diagnostic stewardship and decision making (it's really just antibiotic stewardship in disguise 🤫). Urine samples make a great model for this as the interpretation can vary massively by sampling method! open.substack.com/pub/resistan...
open.substack.com
When cultures lie
A Guide to Diagnostic Stewardship
020
Reposted by Dr Samuel J Pearce
Dorothy Bishop @deevybee.bsky.social · 12/02/2025
Latest blogpost on Musk/Royal Society debacle: deevybee.blogspot.com/2025/02/seve... I look at the reasons that have been given for inaction, and find them wanting. @royalsociety.org
deevybee.blogspot.com
Seven reasons for keeping Elon Musk as a Fellow of the Royal Society
Last November, I wrote a blogpost explaining why I had resigned as a Fellow of the Royal Society (FRS). In brief, over the summer a group ...
26455223
Reposted by Dr Samuel J Pearce
Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 03/02/2025
My letter to ASM leaders that I sent is too long to be posted here, so I'm going to post highlights in case anyone else needs information for their letter. 🧵
1028389
Dr Samuel J Pearce @samueljpearce.bsky.social · 31/01/2025
Interesting work. Nice to see some less invasive tests are non-inferior to current methods! Hope to see this validated with a prospective study for diagnosis or at least ruling in/out hypoadrenocorticism
011