iiinova — where your digital self keeps evolving

Reposted by Samuel King

Adrian Woolfson @adrianwoolfson.bsky.social · 07/08/2026

Congrats to @brianhie.bsky.social and @samuelhking.bsky.social at the @arcinstitute.org on a remarkable publication in @science.org. Time will demonstrate the philosophical importance of this landmark paper.

021

Reposted by Samuel King

Arc Institute @arcinstitute.org · 23/06/2026

Imagine programming protein, DNA, and RNA systems like you would write computer code, or even by natural language prompting of an AI agent. @brianhie.bsky.social and team just made this a reality with Proto: a high-level programming language for generative biology.

1125

Reposted by Samuel King

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · 07/01/2026

Tomorrow, at the #SystemsVirologyJournalClub, @samuelhking.bsky.social will present his work with @brianhie.bsky.social using AI genome language models to generate novel, high-fitness bacteriophages.

041

Reposted by Samuel King

Aditi Merchant @adititm.bsky.social · 19/11/2025

What if we could autocomplete DNA based on function? Today in @Nature, we share semantic design—a strategy for function-guided design with genomic language models that leverages genomic context to create de novo genes and systems with desired functions. 🧵 www.nature.com/articles/s41...

1137

Reposted by Samuel King

Arc Institute @arcinstitute.org · 17/09/2025

In a new preprint from @brianhie.bsky.social's lab, the team reports the first generative design of viable bacteriophage genomes. Leveraging Evo 1 & Evo 2, they generated whole genome sequences, resulting in 16 viable phages with distinct genomic architectures.

43912

Reposted by Samuel King

Fay Lin @faylinphd.bsky.social · 17/09/2025

Genome foundation models, Evo 1 and Evo 2, have now generated viable bacteriophage genomes, demonstrating experimental validation of whole genomes designed by AI! @arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social Read more at GEN: www.genengnews.com/topics/artif...

genengnews.com

AI Designs Viable Bacteriophage Genomes, Combats Antibiotic Resistance

AI-guided design of 16 functional bacteriophage genomes offers a path for phage-based therapies against antibiotic-resistant infections.

095

Samuel King @samuelhking.bsky.social · 17/09/2025

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

35020

Reposted by Samuel King

Brian Hie @brianhie.bsky.social · 19/02/2025

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

12914

Reposted by Samuel King

Aditi Merchant @adititm.bsky.social · 19/12/2024

Excited to have the first project of my PhD out!! By leveraging genomic language model Evo’s ability to learn relationships across genes (i.e., "know a gene by the company it keeps"), we show that we can use prompt-engineering to generate highly divergent proteins with retained functionality. 🧵1/N

1185