Sager Gosai @sagergosai.bsky.social · 22/12/2024Exited to see this preprint led by Tammy Lan in the Sabeti Lab using spatial transcriptomics to study the impacts of aging on the cycling ovaries. www.biorxiv.org/content/10.1...biorxiv.orgAging disrupts spatiotemporal coordination in the cycling ovaryThroughout the female reproductive lifespan, the ovary completes hundreds of cycles of follicle development, ovulation, and tissue regeneration[1][1]–[3][2]. These processes rely on the precise coordi... 000
Reposted by Sager GosaiPeter Koo @pkoo562.bsky.social · 16/11/2024🧬 Genomic DNNs can be trained to learn a lot of different aspects of gene regulation, but they're not perfect and we don't know which predictions are reliable and which ones aren't. We introduce DEGU: Uncertainty-aware Genomic Deep Learning with Knowledge Distillation. 1/n 1339
Reposted by Sager GosaiIan Silverman @iansilverman.bsky.social · 19/11/2024Pleased to share our latest work on genomic- and methylation-based #ctDNA analysis of baseline samples from patients with #DDR and #HRD tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in #ATM www.medrxiv.org/content/10.1...medrxiv.orgComprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profilingThe development of DNA damage response (DDR)-directed therapies is a major area of clinical investigation, yet to date Poly (ADP-ribose) polymerase (PARP) inhibitors remain the only approved therapy i... 011
Reposted by Sager GosaiAaron Quinlan (he/him) @aaronquinlan.bsky.social · 03/12/2024Biology of Genomes 2025 is coming up: - meeting dates: May 6 - 10, 2025 - abstract deadline: Feb 14, 2025 We hope to see you there for another great meeting with a fantastic speaker lineup! meetings.cshl.edu/meetings.asp...meetings.cshl.eduBiology of GenomesCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics. 16634
Sager Gosai @sagergosai.bsky.social · 03/12/2024Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AInature.comMachine-guided design of cell-type-targeting cis-regulatory elements - NatureA generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code. 182
