iiinova — where your digital self keeps evolving

Reposted by Ian Silverman

Sylvain Gigan @sylvaingigan.bsky.social · 18/11/2024

Happy birthday Google Scholar - making my life easier since 2004.

39410

Reposted by Ian Silverman

vonMeyenn Lab @ ETH Zurich @vonmeyennlab.bsky.social · 19/11/2024

🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!! www.nature.com/articles/s41...

nature.com

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

413333

Ian Silverman @iansilverman.bsky.social · 19/11/2024

Pleased to share our latest work on genomic- and methylation-based #ctDNA analysis of baseline samples from patients with #DDR and #HRD tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in #ATM www.medrxiv.org/content/10.1...

medrxiv.org

Comprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profiling

The development of DNA damage response (DDR)-directed therapies is a major area of clinical investigation, yet to date Poly (ADP-ribose) polymerase (PARP) inhibitors remain the only approved therapy i...

011