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Ryan Elliott

@ryanelliott.bsky.social
266 followers 117 following 122 posts

Hematology Resident Physician | Former High School Teacher | Piano Enthusiast | Proud Newfoundlander | Millennial buymeacoffee.com/ryanelliott

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Ryan Elliott @ryanelliott.bsky.social · 26/12/2025
🫁 Just passing on what I thought was a very nice diagram from Med G for respiratory physical examination. Always nice to have some materials on-hand for learners. #medsky #IMsky
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Dana-Farber Cancer Institute @danafarber.bsky.social · 06/12/2025
Jorge Castillo, MD, shares data on an all-oral, non-chemo, fixed-duration regimen for Waldenström macroglobulinemia using pirtobrutinib and venetoclax. The combination delivered rapid, profound and 100% overall responses with manageable side effects and high rate of deep responses. #ASH25
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Vijay G. Sankaran @bloodgenes.bsky.social · 07/12/2025
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25
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Ryan Elliott @ryanelliott.bsky.social · 06/12/2025
#ASH25 let’s goooooo
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Ryan Elliott @ryanelliott.bsky.social · 17/09/2025
📚 This T-cell NHL diagnostic slide has been circulating and provides a nice framework #medsky #hemesky #hemeonc #lymphoma #pathsky #hemepath #Tcells #cellmarkers #biology #hematology #medicine #pathology #oncology #oncsky #diagnostics #meded
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OncLive @onclive.bsky.social · 16/09/2025
Final CAPTIVATE Analysis Data Support Frontline Fixed-Duration Ibrutinib Plus Venetoclax in CLL/SLL #CLL #Hematology www.onclive.com/view/final-c...
onclive.com
Final CAPTIVATE Analysis Data Support Frontline Fixed-Duration Ibrutinib Plus Venetoclax in CLL/SLL | OncLive
Paolo Ghia, MD, PhD, details the final analysis of the phase 2 CAPTIVATE study evaluating frontline ibrutinib/venetoclax in patients with CLL.
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Ryan Elliott @ryanelliott.bsky.social · 08/09/2025
All signed up for the 2025 ASH Annual Meeting. Looking forward to it! #hemesky #ASH25
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Ryan Elliott @ryanelliott.bsky.social · 08/09/2025
🩸 ISTH DIC score (overt ≥ 5) Plt <50=2; 50–100=1 PT >6s=2; 3–6s=1 Fibrinogen <1.0g/L=1 D-dimer: >3× ULN=3; 1–3× ULN=2; none=0 #hemesky #medsky #coag #benignheme
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Thrombosis Canada @thrombosiscan.bsky.social · 04/07/2025
Join us on October 25 for a packed day of thrombosis education for healthcare professionals. Register today at thrombosiscanada.ca/2025Conference
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OncLive @onclive.bsky.social · 06/09/2025
Mosunetuzumab/Polatuzumab Vedotin Is an Effective Off-the-Shelf Combo in R/R MCL @mdanderson.bsky.social @societyofhemonc.bsky.social #SOHO2025 #lymsm #hematology www.onclive.com/view/mosunet...
onclive.com
Mosunetuzumab/Polatuzumab Vedotin Is an Effective Off-the-Shelf Combo in R/R MCL
Treatment with mosunetuzumab plus polatuzumab vedotin yielded high response rates and had a manageable safety profile in BTK inhibitor–exposed MCL.
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Ryan Elliott @ryanelliott.bsky.social · 06/09/2025
🩺 Differentiation Syndrome - complication that can occur during treatment of APL w/ ATRA+ATO Clinical: ⬆️ WBCs ⬆️ Fever ⬆️ edema/body weight/pulmonary infiltrates Mgmt: - high-dose steroids - cytoreduction - antipyretics / cxs / abx for FN - diuresis #hemesky #hemeonc #medsky #APL #APML #leukemia
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Ryan Elliott @ryanelliott.bsky.social · 17/08/2025
Not hard to tell that I’m currently on thrombosis! Having a good experience with the team here at McMaster. #thrombosis #hemesky #hematology
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BaladoCritique : club de lecture médical @baladocritique.bsky.social · 18/07/2025
"Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation." Publié en juillet dans J Thromb Haemost. #MedSky #DIC www.sciencedirect.com/science/arti...
sciencedirect.com
Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation
Compelling evidence supports the need to update the 2001 definition and diagnosis of disseminated intravascular coagulation (DIC) to reflect our curre…
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Ryan Elliott @ryanelliott.bsky.social · 17/08/2025
🩸📖 NEJM 2003: CLOT trial - 676 patients w/ cancer-associated thrombosis (CAT) - Dalteparin vs warfarin. Dalteparin dose: 200 IU/kg sc daily ×1/12 → 150 IU/kg daily ×5/12 (total 6 months). Outcome: ↓ recurrent VTE; no ↑ major bleed in the group who received dalteparin. #hemesky #thrombosis #medsky
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Ryan Elliott @ryanelliott.bsky.social · 15/08/2025
🩸Cancer-associated Thrombosis Trials: LMWH more effective than VKAs CANTHANOX 2002: Enoxaparin vs VKA CLOT 2003: Dalteparin vs VKA ONCENOX 2006: Enoxaparin vs VKA LITE 2006: Tinzaparin vs VKA CATCH 2015: Tinzaparin vs VKA #thrombosis #clinicalTrials #hemesky #medsky #IMsky #oncology #hemeonc
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Ryan Elliott @ryanelliott.bsky.social · 06/08/2025
CARAVAGGIO 2020 (1,170 pts): Apixaban vs dalteparin for cancer VTE. Recurrent VTE 5.6 % vs 7.9 % (non-inf). Major bleed 3.8 % vs 4.0 %; no extra GI bleed. Bottom line: apixaban noninferior to dalteparin without increase in major bleeding in cancer-associated VTE. #medsky #hemesky #thrombosis
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Ryan Elliott @ryanelliott.bsky.social · 06/08/2025
Lesson from this past week: Isolated elevation of anticardiolipin IgM does not meet laboratory criteria for antiphospholipid syndrome! According to EULAR 2023 guidelines below. #medsky #IMsky #rheumsky #hemesky #antiphospholipid #thrombosis
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Blood Journals Portfolio @bloodjournals.hematology.org · 04/08/2025
Ven is effective (91% ORR) and well tolerated in octogenarians, but 43% hd treatment holds and 32% prolonged ramp-up. buff.ly/lNgBN1r #hemesky
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Ryan Elliott @ryanelliott.bsky.social · 04/08/2025
Monoclonal Gammopathy: Paraneoplastic Neuropathy 🧠🩸 AL Amyloidosis: painful + length-dependent + sensory > motor POEMS: symmetric disabling demyelinating polyneuropathy DADS-M: distal loss of proprioception + demyelinating + coarse tremor + mild motor weakness #hemesky #myeloma #medsky #neurosky
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JAMA @jama.com · 19/05/2025
Chronic myeloid leukemia is a myeloproliferative neoplasm. This Review summarizes the epidemiology, diagnosis, and management of chronic myeloid leukemia. ja.ma/4mlR6ez
Figure 1.  Pathogenesis of CML and Mechanism of Action of Available BCR::ABL1 TKIs
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Blood Journals Portfolio @bloodjournals.hematology.org · 02/06/2025
Unveiling the enigma: circulating flowerlike large B-lymphoma cells in the context of angioimmunoblastic T-cell lymphoma buff.ly/bbBzTQG #hemesky #lymphoidneoplasia
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Ryan Elliott @ryanelliott.bsky.social · 05/05/2025
🔬🩸Hemoglobin development (some fundamentals!) Embryo Hb Gower I = ζ2ε2 Hb Gower II = α2ε2 Hb Portland = ζ2γ2 Fetus HbF = α2γ2 Adult HbA = α2β2 ~97% HbA2 = α2δ2 ~2–3% HbF <1% #hemesky #medsky #IMsky #benignheme #hemoglobin #pediatrics
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OncLive @onclive.bsky.social · 19/02/2025
JAK Inhibitor–Based Combos and Mutation-Specific Regimens Comprise the Future of Myelofibrosis Management #MPNsm #hematology #oncology www.onclive.com/view/jak-inh...
onclive.com
JAK Inhibitor–Based Combos and Mutation-Specific Regimens Comprise the Future of Myelofibrosis Management
Claire Harrison, MD, FRCP, FRCPath, discusses research that may evolve the clinical use of JAK inhibitors and mutation-specific therapies in myelofibrosis.
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Frak. @frakbuddy.bsky.social · 20/02/2025
Workin. CML in a 27 Year old. #haematology #hematology
Blood film picture of a patient with CML showing a variety of immature and mature white blood cells
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Ryan Elliott @ryanelliott.bsky.social · 06/02/2025
💊 Abatacept Humanized protein construct from recombinant DNA (CTLA4 + IgG1 Fc) grown in hamster ovary cells. Selectively binds to CD80/86 on APCs, inhibiting CD80/86-CD28 costimulatory signal essential for full T-cell activation. #medsky #IMsky #rheumsky #biologics (Herrero-Beaumont et al., 2012)
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OncLive @onclive.bsky.social · 22/01/2025
Isatuximab Plus VRd Wins EU Approval for Newly Diagnosed, Transplant-Ineligible Multiple Myeloma #mmsm #Hematology www.onclive.com/view/isatuxi...
onclive.com
Isatuximab Plus VRd Wins EU Approval for Newly Diagnosed, Transplant-Ineligible Multiple Myeloma
The EMA’s CHMP has approved isatuximab in combination with VRd for transplant-ineligible patients with newly diagnosed multiple myeloma.
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HemaSphere Journal @hemasphere-journal.bsky.social · 23/01/2025
This recently published study highlights the prognostic significance of high-risk cytogenetic abnormalities in multiple myeloma. Genetic alterations like t(4;14), del(17p), and +1q are linked to poorer prognosis and shorter survival  #MM #hematology 👉https://bit.ly/3PzY1BT
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Ryan Elliott @ryanelliott.bsky.social · 03/01/2025
🩸Large Granular Lymphocytic Leukemia Indolent clonal proliferation of mature cytotoxic T cells - Neutropenia/anemia - a/w autoimmunity - CD8+ T cells w/ NK cell markers - intrasinusoidal bone marrow/spleen/liver path ~50% STAT3 / STAT5b mutation #hemesky #pathsly #hemepath #IMsky #medsky #leukemia
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Ryan Elliott @ryanelliott.bsky.social · 29/12/2024
💊 Lung Cancer FDA-approved medications in 2024 #oncsky #medsky
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Ryan Elliott @ryanelliott.bsky.social · 26/12/2024
This episode was great! #hemesky #lymphoma #MCL
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Oncology Brothers @oncbrothers.bsky.social · 24/12/2024
2024 approvals: Summary of 12 new 💊indications in heme malignancies by FDA: 1. #Zanubrutinib 2. #Ponatinib 3. #LisoCel x2 4. #Imetelstat 5. #Epcortimab 6. #Daratumuab 7. #Axatilimab 8. #Isatuximab 9. #Asciminib 10. #ObiCel 11. #Revumenib #HemeSky #OncSky #mmsm #leusm #MedSky #lymsm
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Peter van Galen @vangalenlab.bsky.social · 23/12/2024
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
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Ryan Elliott @ryanelliott.bsky.social · 23/12/2024
🩸CML Treatment #ASCO2024 1. Assess (🫀,🫁,GI,comorbs) 2. Risk strat (Sokal, Hasford, EUTOS) 3. Treatment - Low risk: Imatinib - Int/high risk: 2nd-gen TKIs 4. Monitor (bcr-abl PCR🧪) #hemesky #hemeonc #oncsky #CML #leukemia
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VJHemOnc @vjhemonc.bsky.social · 23/12/2024
Check out our recent feature article, which covers the late-breaking abstracts presented at #ASH24! Don't worry if you missed out - we've got you covered!📖🩸 👉https://buff.ly/3Bpau84 #LymSM #HemOnc #SickleCellDisease #MPNsm @ash-hematology.bsky.social #MedSky #BloodSky #HemeSky #HemeOnc
buff.ly
ASH 2024 press briefing rundown: treating not-so-benign hematology conditions | VJHemOnc
VJHemOnc is thrilled to bring you the latest updates from the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, held in New Orleans, LA, from 10 - 13 December 2022, with a…
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Ryan Elliott @ryanelliott.bsky.social · 22/12/2024
💊 Antiarrhythmics - Vaughan Williams Classification 🫀Class I (Ia, Ib, Ic) - Na+ Channel Blockers 🫀Class II - Beta Blockers 🫀Class III - K+ Channel Blockers 🫀Class IV - Ca2+ Channel Blockers 🫀Class V agents - Other #medsky #IMsky #internalmedicine #cardiosky
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Ryan Elliott @ryanelliott.bsky.social · 20/12/2024
🩸AML Treatment (simplified) Here’s a nice general framework to treatment in AML! #hemesky #hemeonc #oncsky #medsky #AML #leukemia #ASCO24
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Ryan Elliott @ryanelliott.bsky.social · 19/12/2024
🩸Anticoagulant Reversal Warfarin =🚫II,VII,IX,X Reverse = Vitamin K, 4-PCC (II,VII, IX, X) Heparin =🚫II,X Reverse = Protamine (binds heparin) Dabigatran =🚫II Reverse = Idacrucizumab (anti-dabigatran mAb) Xa inhibitors (Apixaban) Reverse = Andexanet alfa (Xa decoy & binds drug) #hemesky #medsky
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OncLive @onclive.bsky.social · 17/12/2024
Glofitamab Produces Durable Remissions in R/R Mantle Cell Lymphoma @lymphclinican.bsky.social @ash-hematology.bsky.social #ASH24 #lymsm #oncology www.onclive.com/view/glofita...
onclive.com
Glofitamab Produces Durable Remissions in R/R Mantle Cell Lymphoma
Glofitamab generated high response rates and durable remissions in R/R mantle cell lymphoma, including high-risk subgroups, with sustained MRD negativity.
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Ryan Elliott @ryanelliott.bsky.social · 18/12/2024
🩸 Febrile Non-Hemolytic (FNHTR): - Time: ≤ 4 hours - Cause: cytokines in donor blood - Prevention: H2 blockers, antipyretics, leukoreduction - Mgmt: stop infusion, antipyretrics, H2 blockers, meperidine (rigors), r/o other causes, notify blood bank #hemesky #medsky #IMsky #internalmedicine
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drfranciscomd.bsky.social @drfranciscomd.bsky.social · 15/12/2024
At #ASH24, the IMMagine-1 trial presented promising results for anitocabtagene autoleucel (anti-BCMA CAR T-cell therapy) in relapsed/refractory multiple myeloma, showing high response rates in heavily pretreated patients. #MultipleMyeloma #CancerResearch
ash.confex.com
Paper: Phase 2 Registrational Study of Anitocabtagene Autoleucel for the Treatment of Patients with Relapsed and/or Refractory Multiple Myeloma: Preliminary Results from the IMMagine-1 Trial
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Ryan Feldman PharmD DABAT @empoisonpharmd.bsky.social · 14/12/2024
One thing I think about way too much is that after you die, your white blood cells keep living for up to three days pubmed.ncbi.nlm.nih.gov/8366783/. Just little security guards, wandering the apocalypse, loyal to the end, slowly realizing no one is left #Medsky #PharmSky #RxSky #hemesky #Skyence
pubmed.ncbi.nlm.nih.gov
Cellular changes and time since death - PubMed
Based on a hypothesis that post-mortem cellular (chiefly nuclear) changes in the white blood cells could reliably be correlated with the time interval since death, (ti), serial observations were made ...
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Ryan Elliott @ryanelliott.bsky.social · 15/12/2024
💊 Chemotherapy: disrupting cancer cell cell growth and survival at multiple levels. This handy diagram summarizes chemotherapy classes and where they fit according to their mechanism of action ⚙️ #oncsky #hemeonc #hemesky #pharmsky #medsky #IMsky #cancer #chemo (Falzone et al., 2023. Cell)
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Ryan Elliott @ryanelliott.bsky.social · 15/12/2024
💊 This diagram covers the ~broad spectrum~ of antibiotic activity. #medsky #IMsky #internalmedicine #IDsky #punsky #puns #emimcc
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Ryan Elliott @ryanelliott.bsky.social · 14/12/2024
🩸Hematopoietic stem cell differentiation with cytokine regulation #hemesky #hemeonc #medsky #IMsky #internalmedicine #hemepath #pathsky #stemcells
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JAMA @jama.com · 14/12/2024
Most viewed in the last 7 days from JAMA: Care guided by measurement of procalcitonin reduces antibiotic duration safely compared with standard care, but CRP does not. ja.ma/3ZDRElB
Kaplan-Meier Curves for Probability of Antibiotic Duration and Mortality to 28 Days
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Ryan Elliott @ryanelliott.bsky.social · 14/12/2024
🩸Neutrophilic myelocyte Cytoplasm slightly basophilic to cream-coloured prominent red-purple azurophilic (primary) granules and numerous specific (secondary) granules nucleoli absent usually slightly indented nucleus w/ red blue and slightly condensed chromatin #hemeky #hemepath #pathsky #IMsky
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Ryan Elliott @ryanelliott.bsky.social · 13/12/2024
🫀Cardiac tamponade vs constrictive pericarditis vs restrictive cardiomyopathy A big thanks to #IMR for this handy comparison table. Good for reference down the road or for someone like myself currently studying for the #InternalMedicine Royal College exam here in Canada. #cardiosky #medsky #IMsky
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Ryan Elliott @ryanelliott.bsky.social · 13/12/2024
🌡️ Fever of Unknown Origin (FUO) = temp >38.3C multiple times x 3 weeks without obvious cause Infections: 20-40%. Connective tissue disorders: 20% Malignancy: 10-20% Undiagnosed: 20% Drugs (e.g., phenytoin): rare #medsky #IMsky #internalmedicine #IDsky #hemeonc #hemesky #oncsky #rheumsky
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Erica Saint Clair, PhD @esaintclair.bsky.social · 12/12/2024
A nice handy slide from the FDA sessions at #ASH24 of CAR-T therapy approvals to date!
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