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Rogier Min

@rogiermin.bsky.social
374 followers 197 following 19 posts

Neuroscientist | Astrocytes | Electrophysiologist interested in Ions, Water and the Brain | Leukodystrophies | Assistant professor @ Amsterdam UMC

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Rogier Min @rogiermin.bsky.social · 11/06/2025
🚨 PhD position in astrocyte physiology! Join us in Amsterdam to explore how astrocytes dynamically regulate brain water flow! Apply using the link below: 🧠🔬🌍 🔗 werkenbij.amsterdamumc.org/en/publicatie-1179368 #Neuroscience #PhD #Astrocytes #MLC #SUPERGLUE
werkenbij.amsterdamumc.org
Vacatures - PhD Cellular Neuroscience - Astrocyte Physiology - Amsterdam UMC
Amsterdam Leukodystrophy Center is looking for a motivated PhD candidate to explore the fundamental physiology of astrocytes in the brain, in the context of brain fluid regulation.
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Rogier Min @rogiermin.bsky.social · 02/06/2025
Fresh from the lab! In this new paper, PhD student Sven Kerst shows how phenotypes observed in isolated cell models for the leukodystrophy MLC are also observed in intact astrocytes in acute brain slices! Glia | Neurobiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts
Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and exten...
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Rogier Min @rogiermin.bsky.social · 07/04/2025
It was a joy to write this perspective together with Marjo van der Knaap. Her deep knowledge of white matter disorders is truly exceptional! And our paper shows how studying rare diseases can illuminate fundamental brain processes - with implications far beyond! 🧠✨ 11/11 < the end >
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Rogier Min @rogiermin.bsky.social · 07/04/2025
Identifying the first pathological event in MS matters: 🧪 For better models - most current models are based on triggering an immune attack against myelin... 💊 For better therapies - remyelination is bound to fail if astrocytes can’t support it!! 10/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
This model fits well with beautiful neuropathology studies describing early astrocyte damage in MS lesions. And with studies showing early myelin abnormalities (swelling, vacuoles, blisters; similar to what we see in MLC) which precede demyelination! 9/11 pubmed.ncbi.nlm.nih.gov/23322421/
pubmed.ncbi.nlm.nih.gov
The astrocyte in multiple sclerosis revisited - PubMed
Among the constituent cell types of the multiple sclerosis (MS) plaque, the astrocyte has been the least considered as a player in the pathogenesis of the lesion. Traditionally, it has been assigned a...
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Rogier Min @rogiermin.bsky.social · 07/04/2025
We propose a similar mechanism in MS: an immune attack on astrocyte endfeet - triggered by autoimmunity against GlialCAM - disrupts astrocyte homeostasis. Myelin damage follows secondarily, and is a consequence of loss of homeostatic support. 8/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
Genetic defects to these proteins in MLC disrupts endfoot function and disturbs ion and water homeostasis. As a consequence myelin swells and forms vacuoles - not from a direct attack, but because of loss of astrocytic support. 7/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
Astrocytes express GlialCAM as part of a protein complex that is present in the endfeet with which they enwrap blood vessels in the brain. This complex is crucial for brain ion and water homeostasis (and further consists of MLC1, Aquaporin-4 and GPRC5B). 6/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
GlialCAM may not sound familiar - but our lab @amsterdamleuko.bsky.social has studied this astrocyte protein for years in the context of a rare genetic disease called MLC (megalencephalic leukoencephalopathy with subcortical cysts), a childhood-onset white matter disorder (leukodystrophy). 5/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
In trying to fight EBV, the immune system may create antibodies that mistakenly target GlialCAM. Why? Because part of GlialCAM resembles an EBV protein - a case of molecular mimicry. 4/11 www.nature.com/articles/s41...
nature.com
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM - Nature
The identification of high-affinity molecular mimicry between the Epstein–Barr virus (EBV) transcription factor EBNA1 and the CNS protein GlialCAM provides a mechanistic link between multiple sclerosi...
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Rogier Min @rogiermin.bsky.social · 07/04/2025
A clue came in 2022: MS patients can develop antibodies against a protein called GlialCAM - triggered by infection with the very common Epstein-Barr virus (EBV). Nearly all MS patients have had EBV before disease onset. 3/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
Most textbooks describe MS as an immune attack on the fatty myelin layer that insulates axons. But the hunt for a specific myelin antigen in MS hasn’t been very successful… So what’s going on? 2/11
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Rogier Min @rogiermin.bsky.social · 07/04/2025
Excited to share our latest paper! We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet. A short thread on this new perspective 1/11
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Rogier Min @rogiermin.bsky.social · 18/12/2024
I’m very excited that NWO will fund our ENW-XL consortium grant ‘Superglue’!! The project will focus on astrocytes, the multifunctional glue cells that keep our brain working. Let’s see what we will discover 🤩 !! www.nwo.nl/nieuws/64-mi...
nwo.nl
64 miljoen euro naar grensverleggende fundamentele onderzoeksprojecten | NWO
21 onderzoeksconsortia krijgen de kans om een doorbraak te maken dankzij de financiering van de Open Competitie ENW-XL. Van fundamenteel onderzoek naar het effect van bepaalde materialen op de methaan...
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Jinte Middeldorp, PhD @jinteneuro.bsky.social · 06/12/2024
We extended the deadline with a few days. Abstracts can be submitted until Dec 12.
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Philip Hasel @philiphasel.bsky.social · 25/11/2024
PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)! www.findaphd.com/phds/project...
findaphd.com
(VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh on FindAPhD.com
PhD Project - (VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh, listed on FindAPhD.com
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Ardem Patapoutian @ardemp.bskyverified.social · 22/11/2024
Nice shots showing open and close PIEZO ion channels both on slide and on arm!
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Rogier Min @rogiermin.bsky.social · 22/11/2024
Easy answer: there’s no such thing…
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Ardem Patapoutian @ardemp.bskyverified.social · 22/11/2024
Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.
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Rogier Min @rogiermin.bsky.social · 19/11/2024
My first post in the sky is a: Job Alert! We are looking for a PhD student to study astrocyte dysfunction in the rare neurological disease MLC. Looking for a challenge? See the job advertisement below! werkenbij.amsterdamumc.org/en/vacatures...
werkenbij.amsterdamumc.org
Vacatures - PhD Understanding and repairing astrocyte dysfunction in the leukodystrophy MLC - Amsterdam UMC
The Amsterdam Leukodystrophy Center is searching for a motivated PhD candidate, for a collaborative project on understanding astrocyte dysfunction in the leukodystrophy MLC.
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Rogier Min @rogiermin.bsky.social · 19/11/2024
Thanks!
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Roslyn Bill @roslynbill.bsky.social · 18/11/2024
Join me to do your PhD on aquaporins as part of the Midlands Integrative Biosciences Training Partnership funded by BBSRC. Please get in touch if you are interested! The project is co-supervised by @kitchenphil.bsky.social The deadline is 16th January 2025! warwick.ac.uk/fac/cross_fa...
warwick.ac.uk
Professor Roslyn Bill
Professor Roslyn Bill
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Phil Kitchen @kitchenphil.bsky.social · 17/11/2024
🌟PhD Opportunity in membrane biophysics!🌟 Fully-funded 4 year PhD studentship at @AstonAIME with @NaomiLPollock1 using neutron scattering at @isisneutronmuon to study lipid interactions with membrane proteins. Apply now: www.aston.ac.uk/graduate-sch... #PhDOpportunity #Biophysics
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Monica Carson @brainimmunity.bsky.social · 17/11/2024
some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed? go.bsky.app/MHtJzeC
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Rogier Min @rogiermin.bsky.social · 18/11/2024
Would love te be added, thanks!
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Shane Liddelow @liddelowsa.bsky.social · 17/11/2024
There are lots of us missing, but so many joining so quickly Please do share, and comment below to be added go.bsky.app/5f2V6L6 (microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)
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Rogier Min @rogiermin.bsky.social · 18/11/2024
Would love to be added! Thanks for setting this up!
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