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Robin H. van der Weide

@robinhweide.bsky.social
118 followers 124 following 8 posts

Chromatin Systems Biology Assistant Professor at Center for Molecular Medicine - UMC Utrecht

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Robin H. van der Weide @robinhweide.bsky.social · 18/09/2026
Officially not a one-person show anymore 🎉 Excited to welcome Sandra, Giacomo, Ruben, and Anouk to the lab at the @umcutrecht.bsky.social. We're diving into chromatin systems biology together. Feels good to say "we" now.
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Robin H. van der Weide @robinhweide.bsky.social · 06/07/2026
Very happy to see this story out in the wild!
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Elzo de Wit lab @ NKI @dewitlab.bsky.social · 15/04/2026
New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵
genesdev.cshlp.org
Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
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Robin H. van der Weide @robinhweide.bsky.social · 15/04/2026
💼 Hiring a Staff Technician at my Chromatin Systems Biology lab (UMC Utrecht). A wet lab role with real ownership: co-develop research lines, contribute to publications, build something from the ground up. Permanent position, pending tenure. Details & apply:
werkenbijumcutrecht.nl
Vacature — Staff Technician - Wetlab
We are looking for a motivated and experienced Staff Technician to take ownership of the day-to-day operations of our wet lab. You ensure that operations run smoothly and are responsible for executing...
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Hubrecht Institute @hubrechtinstitute.bsky.social · 13/03/2026
@amandaanderssonr.bsky.social, @antonelladost.bsky.social, @robinhweide.bsky.social and @sorayang.bsky.social started their own labs in early 2026. Read about their time at the Hubrecht Institute, their new research groups and their transition into independence here: www.hubrecht.eu/postdocs-sta...
pictures of the four postdoctoral researchers
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Amanda Andersson-Rolf @amandaanderssonr.bsky.social · 03/01/2026
We are hiring! Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se. If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out! #hiring #sciencejob #STEMJobs
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Robin H. van der Weide @robinhweide.bsky.social · 02/01/2026
🌱 As of Jan 1, I started as Assistant Professor at UMC Utrecht – Center for Molecular Medicine. Very grateful to @dewitlab.bsky.social and @jopkind.bsky.social and to the many other people who supported me along the way. I’ll be launching the lab soon, focusing on Chromatin Systems Biology.
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Robin H. van der Weide @robinhweide.bsky.social · 30/12/2025
Thrilled to share Marta Moreno Gonzalez’s paper, where we benchmarked whether existing imputation approaches can be repurposed for single-cell hPTM datasets. This is also a special milestone for me, as it’s my first last-author paper. @hubrechtinstitute.bsky.social @umcutrecht.bsky.social
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Lars Jansen Lab @jansenlab.bsky.social · 25/11/2025
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...
differential contribution of H3K9 methyltransferases to boundaries at satellites
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Posit @posit.co · 19/11/2025
Introducing bluffbench, a new tool to evaluate how well LLMs actually see data plots. When we trick LLMs with secret #RStats transformations, they can miss the visual contradiction. bluffbench helps us measure this "blind spot" in AI coding agents. Learn more: posit.co/blog/introdu...
posit.co
When plotting, LLMs see what they expect to see - Posit
Data science agents need to accurately read plots even when the content contradicts their expectations. Our testing shows today's LLMs still struggle here.
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samuel mehr @mehr.nz · 17/11/2025
periodic reminder of the existence of Atkinson Hyperlegible, a free font available from the Braille Institute designed to improve readability for people with low vision I use it in talks because it's pretty and also because, as an audience member, I am perpetually squinting at people's slides
brailleinstitute.org
Atkinson Hyperlegible Font - Braille Institute
Read easier with Atkinson Hyperlegible Font, crafted for low-vision readers. Download for free and enjoy clear letters and numbers on your computer!
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Robin H. van der Weide @robinhweide.bsky.social · 21/08/2025
I need a reference manager that's amazing for both organizing and reading on a laptop & tablet. 📑 It's a showdown: Paperpile vs. ReadCube Papers. What's your go-to and why? #Academia #Paperpile #ReadCube
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Nature Biotechnology @natbiotech.nature.com · 30/07/2025
Shortcomings of silhouette in single-cell integration benchmarking - @uweohler.bsky.social @prauten.bsky.social @mdc-bimsb.bsky.social @mdc-berlin.bsky.social @humboldtuni.bsky.social go.nature.com/4fcQzZr
go.nature.com
Shortcomings of silhouette in single-cell integration benchmarking - Nature Biotechnology
Silhouette score is unsuitable as a metric for single-cell data integration.
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Nature @nature.com · 18/07/2025
Agony aunt 🖋️ A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take? go.nature.com/3UhImt0
go.nature.com
Should I tell anyone that I suspect misconduct in a paper I’m reviewing?
A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take?
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Anton Goloborodko @golobor.bsky.social · 15/07/2025
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/
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Konrad Chudzik @konrad-chudzik.bsky.social · 08/05/2025
🚨 Preprint 🚨 Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens! doi.org/10.1101/2025...
biorxiv.org
Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...
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Konrad Chudzik @konrad-chudzik.bsky.social · 14/04/2025
🚨 Preprint alert 🚨 Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇 doi.org/10.1101/2025...
doi.org
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
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Anshul Kundaje @anshulkundaje.bsky.social · 25/12/2024
Our ChromBPNet preprint out! www.biorxiv.org/content/10.1... Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
biorxiv.org
ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants
Despite extensive mapping of cis-regulatory elements (cREs) across cellular contexts with chromatin accessibility assays, the sequence syntax and genetic variants that regulate transcription factor (T...
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Fabian Theis @fabiantheis.bsky.social · 12/12/2024
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.1101/2024.12.11.627935v1
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Jop Kind @jopkind.bsky.social · 27/11/2024
Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM
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Erome Hankore @eromehankore.bsky.social · 25/11/2024
1. You have limited time to make scientific contributions. Do the big things 2.Go back and forth between day and night science 3. Give adequate attention to the thinking and analysis aspects of research 4. Do your go-no-go experiments early on to avoid wasting time 5. Face risk early And more 👇🏾
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Anshul Kundaje @anshulkundaje.bsky.social · 24/11/2024
I used to have imposter syndrome. I don't any more. At some point I came to terms with the fact that I'm really an imposter. I'm totally ok with it & simply decided to do my best with the opportunities that presented themselves to me, until my luck runs out. It's surprisingly effective.
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Altmetric @altmetric.com · 18/11/2024
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
docs.bsky.app
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
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Itai Yanai @itaiyanai.bsky.social · 09/11/2024
Doing good science is 90% finding a science buddy to constantly talk to about the project.
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