Like the soldiers they battle to save, combat medics in Ukraine are under constant attack. Three years after the invasion, one NHS doctor bears witness

Each time a man stands up for an ideal, or acts to improve the lot of others, or strikes out against injustice, he sends forth a tiny ripple of hope.Robert F. Kennedy, Senior

Since early 2024, an unprecedented spread of the Oropouche virus has been observed in Brazil and beyond in Latin America. Severe clinical consequences have been described, including early reports of d...

Substantial reductions in prevalence as measured by PCR were predicted with primaquine and tafenoquine regimens if these could be implemented with high coverage and adherence. The benefits of preventi...

Background The countries within the Greater Mekong Region of Southeast Asia have pledged to eliminate malaria by 2030. Elimination of Plasmodium vivax malaria is challenging as it requires radical cur...

Background The WHO malaria treatment guidelines recommend a total dose in the range of 3·5 to 7·0 mg/kg of primaquine to eliminate Plasmodium vivax ( P. vivax ) hypnozoites and prevent relapses. There...

Participation in Brazil’s Bolsa Familia Program, one of the largest conditional cash transfer programs in the world, was associated with large reductions in tuberculosis incidence and mortality among ...

The WHO Guidelines for malaria bring together the Organization’s most up-to-date recommendations for malaria in one easy-to-navigate online platform

Spread of Antifungal-Resistant <em>Trichophyton indotineae</em>, United Kingdom, 2017–2024

Hwang YH, et al. J Korean Med Sci. 2024 Oct;39(49):e314. https://doi.org/10.3346/jkms.2024.39.e314

Malaria chemoprophylaxis with weekly dihydroartemisinin–piperaquine in children with sickle cell anaemia is safe and considerably more efficacious than monthly sulfadoxine–pyrimethamine. However, monthly sulfadoxine–pyrimethamine was associated with fewer episodes of non-malaria-related illnesses, especially in children 5 years or older not receiving penicillin prophylaxis, which might reflect its antimicrobial effects. In areas with high P falciparum antifolate resistance, dihydroartemisinin–piperaquine should be considered as an alternative to sulfadoxine–pyrimethamine for malaria chemoprevention in children younger than 5 years with sickle cell anaemia receiving penicillin-V prophylaxis.

Triple artemisinin-based combination therapies (TACTs) can delay the spread of antimalarial drug resistance. Artesunate–amodiaquine is widely used for…

Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant ...

RH5.1/Matrix-M appears safe and highly immunogenic in African children and shows promising efficacy against clinical malaria when given in a delayed third-dose regimen. This trial is ongoing to further monitor efficacy over time.

Infective endocarditis (IE) is commonly associated with a few pathogens such as staphylococci, streptococci, enterococci and HACEK organisms (Haemophilus s

Egypt was added to the list of malaria-free places in 2024, but climate change, conflict and other threats could increase cases especially in Africa.

Plasmodium vivax parasites can lie dormant in the liver as hypnozoites, activating weeks to months after sporozoite inoculation to cause relapsing ...

This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...

Purpose Anidulafungin is recommended as a first-line treatment for invasive Candida infections in critically ill patients. Pharmacokinetic (PK) variability is large in critically ill patients, potenti...

Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

Information about the 2024 dengue outbreak.

Here, using samples from a randomized controlled trial, the authors show that a multiplex immunoassay (MultiCruzi), paired with statistical analysis, can predict early treatment efficacy in adult Chag...

An eco-friendly ally in the fight against mosquito infestations

Case counts for Oropouche virus are still low but rising dramatically. What's going on? And then there's a study that raises the possibility that insect bites aren't the only way the virus can spread.

We showed that the UVA score performed best in predicting mortality among febrile participants by the time follow-up compared with MEWS and qSOFA, across all four study sites. The UVA score could be a...

An array of microhaplotypes – small segments of ≤200 nucleotides with heterozygous multiple-SNP exhibiting multiple allelic combinations – were identi…

A new study has found methaemoglobin levels during treatment for vivax malaria could be used to predict whether a patient would have recurrent malaria.