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Ryan Z Friedman, PhD

@rfriedman22.bsky.social
505 followers 281 following 37 posts

Gene regulation, machine learning, data viz | Postdoc with Cole Trapnell, comp/systems bio PhD with Barak Cohen and Mike A White 🏳️‍🌈✡️ he/him ryanzfriedman.com

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Reposted by Ryan Z Friedman, PhD
Jay Shendure @jshendure.bsky.social · 30/07/2026
New preprint from Shendure Lab on Locus-Scale aka Long-@$$ MPRAs led by the amazing Abby McGee & @carinabiar.bsky.social Most MPRAs test ~300 bp fragments next to a promoter. But real enhancers are bigger, act combinatorially and from a distance. 1/n www.biorxiv.org/content/10.6...
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 30/06/2026
Syd’s work is so cool and has wowed me since the day I first saw it. Check out her amazing preprint!!!
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Reposted by Ryan Z Friedman, PhD
William DeWitt @wsdewitt.github.io · 27/06/2026
Spectacular preprint led by @sydsat.bsky.social in @ohnolog.bsky.social lab, @uwgenome.bsky.social. Neutrophils precede gastrulation in killifish and rapidly patrol the yolk. (1/2)
doi.org
Early immune cell development precedes gastrulation in annual killifish
During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 12/06/2026
Hello! I am honored to say that I won a departmental Outstanding Service Award!
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 20/05/2026
Do you work at a public university? Does it offer retirement benefits to postdocs? Does it matter whether or not postdocs have a fellowship? Let me know!
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Reposted by Ryan Z Friedman, PhD
Liz Haswell @ehaswell.bsky.social · 20/02/2026
New post on Unprofessoring. Is there really "No Other Choice" or are we giving in to "narratives of inevitability"? Thanks to a post by @docfreeride.bsky.social for the framing.
A stack of old books and the title "Narratives of AI inevitability"
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 08/09/2025
I decided to try out blogging! My first post is a reflection of my time on science Twitter and why I decided to start blogging. I'm going to give Bluesky a second chance, but It's nice to have a space for casual long-form writing ryanzfriedman.com/2025/09/06/s...
ryanzfriedman.com
Reflections of an ex-Twitter user
I’ve had this website for almost 5 years. In that time, it’s been pretty bare-bones, primarily serving as a landing page for me to share my general scientific interests with the world. I built a blog ...
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 08/01/2025
My thesis work on active machine learning to model regulatory DNA is now out in Cell Systems! We answer the question: When you can synthesize any DNA sequence you want, how do you decide which ones are worth testing? www.sciencedirect.com/science/arti...
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Reposted by Ryan Z Friedman, PhD
Holden Thorp @holdenthorp.bsky.social · 26/04/2024
I posted an editorial yesterday on the need for neurodiversity in science where I also disclosed my own diagnosis as autistic. I also wrote a substack on my journey to the disclosure also in this thread. #actuallyautistic www.science.org/doi/10.1126/...
science.org
Science needs neurodiversity
All brains work differently. Individuals process information and engage with the world in ways that are influenced by a multitude of biological, cultural, and social factors. In the world of science, ...
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 20/02/2024
We substantially revised our active learning manuscript. A brief summary of what's new. TLDR: several new analyses, benchmarking w a 2nd MPRA dataset, and a refocused argument on active learning to leverage the capacity of MPRAs to generate large datasets. www.biorxiv.org/content/10.1... 1/8 🧬🔄
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 17/01/2024
A project I contributed to during grad school is now up at PLoS Comp Bio! We used the MAVE-NN package by @jbkinney.bsky.social's group to learn about the behavior of synthetic regulatory elements 🧬🔄 Keep an eye on @genologos.bsky.social's Twitter for more details. journals.plos.org/ploscompbiol...
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 17/01/2024
I want to reorganize my @paperpile.bsky.social. I have folders covering broad topics with very few subfolders. Tags are for different manuscripts. Is there anyone in genomics 🖥️🧬 who wants to share how they organize their reference managers? I'm looking for more meaningful and detailed categories.
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Reposted by Ryan Z Friedman, PhD
Peter Koo @pkoo562.bsky.social · 05/12/2023
🤗
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 04/12/2023
I've had several software engineers ask me recently about transitioning into genomics/comp bio from tech. I never know what to say -- everyone I know in the field in industry went to school for biology/comp bio. Anyone have any suggestions, either of what to say or concrete resources to provide? 🧬🖥️
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Reposted by Ryan Z Friedman, PhD
Dr. Stephanie @punkrockscience.bsky.social · 06/10/2023
“The initial data leak was… 1 million lines of data for Ashkenazi people.” “The information… includes full names, usernames, profile photos, sex, date of birth, genetic ancestry results, and geographical location.” Well, that’s surely not going to be a fucking problem. (sarcastically) 🧪
bleepingcomputer.com
Genetics firm 23andMe says user data stolen in credential stuffing attack
23andMe has confirmed to BleepingComputer that it is aware of user data from its platform circulating on hacker forums and attributes the leak to a credential-stuffing attack.
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Reposted by Ryan Z Friedman, PhD
Jonathan Pritchard @jkpritch.bsky.social · 01/10/2023
I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"
web.stanford.edu
An Owner's Guide to the Human Genome
An Owner's Guide to the Human Genome
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Ryan Z Friedman, PhD @rfriedman22.bsky.social · 27/09/2023
Hello, world! I'm a computational biology postdoc at UW in Seattle interested in genomics 🖥️ 🧬, gene regulation 🧬 🔄, machine learning, data viz, and zebrafish 🐟 #DevBio. Also enjoy emo/punk music, sci-fi books, cooking, and gaming! #LGBTQSTEM 🏳️‍🌈 #HiSciSky
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