iiinova — where your digital self keeps evolving

Reposted by Tyler Sloan @Quorumetrix Studio

Wei-Chung Allen Lee @darbly.bsky.social · 09/06/2026

Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

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Reposted by Tyler Sloan @Quorumetrix Studio

John Tuthill @tuthill.bsky.social · 09/12/2025

Video abstract for our preprint, “Connectome simulations identify a central pattern generator circuit for fly walking”, bit.ly/4pubCuN Animated by T Sloan @quorumetrix.bsky.social, narrated by @sarahpugly.bsky.social, music by J McNamara, collab w @bingbrunton.bsky.social. youtu.be/twAZlL6olS4

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Connectome simulations identify a central pattern generator circuit for fly walking

YouTube video by Bing Wen Brunton

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 07/04/2025

This was a funny experience, my first 'hit' on YouTube where I experienced a whole spectrum of human opinions. The three most common comments were: - Whoever made this music is an idiot - Whoever made this music is a genius - Can it play Doom? From the MICrONS cubic millimeter youtu.be/blaS5fBJdsE

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A Cubic Millimeter of Mouse Brain

YouTube video by Quorumetrix Studio

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 07/04/2025

I'm reposting this video as it is going to be relevant again. A narrated primer on the field of #connectomics. With some historical re-enactments, a few easter eggs for the real #neurds, and some of my best #neuro visualizations. youtu.be/VPaxhoRgqgU #neuroscience #sciviz

youtu.be

The Neuron, the Synapse, and the Connectome

YouTube video by Quorumetrix Studio

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Reposted by Tyler Sloan @Quorumetrix Studio

Søren Grubb @sorengrubb.bsky.social · 18/03/2025

Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology! We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social 📢 Free for NorDoc PhD students, but open to all! Apply now! lnkd.in/dU_fxqqu

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Reposted by Tyler Sloan @Quorumetrix Studio

E11 Bio @e11bio.bsky.social · 09/02/2025

Our work in connectomics is featured in @asimovpress.bsky.social! We’re building new tools to map the brain with greater precision and scale!

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Reposted by Tyler Sloan @Quorumetrix Studio

Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 06/02/2025

Together with Christian Tischer, 3D rendering of multi-res microscopy data was added to MoBIE FIJI plugin using #BigVolumeViewer. Check any remote datasets (like @dudinlab.bsky.social maps of protists using ExM) in the highest quality. For full details read forum.image.sc/t/mobie-plus...

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 05/02/2025

Also, am interested to see if it can translate an entire repository of code, say from R to Python. I've done this function-by-function with chatGPT before, verifying output matched either exactly or directionally. Since it's agentic, I bet it would streamline the whole process.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 05/02/2025

Fair, but it was more a test of how reliably it extracts reported values from research papers (something elicit is good at) and summarizes + packages it in a machine readable format (3.5 onwards very good at). Most curious to see how it would rationalize its choices for the missing values casebycase

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 05/02/2025

Format results in a csv with columns for cell_type and each of the extracted/estimated parameters. Include column flags to indicate if data exctracted or estimated. If extracted provide reference, if estimated provide rationale/method. Format table in units directly compatible with brian2 model.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 05/02/2025

Let's take it up a notch: "For every neuron type I want to know it's physiology / firing parameters, including where possible: membrane constant, resting potential, reset potential, refractory period, resistance, capacitance. Do this for as many neuron types as possible. Infer when data unavailable.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 04/02/2025

Now how do I turn this into a podcast again?

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 04/02/2025

Not just the theaters but the space they occupy in culture: Sagan, Tyson, Cosmos ... who comes to mind? The theaters are a downstream effect of a difference between the scientific cultures. Q: What events/ influences(obvious or not) account for the different cultural trajectories between the fields?

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 04/02/2025

Why does one field build $50m theaters and the other sends grad students to elementary schools with a bucket of cow brains?

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 04/02/2025

1. Both. While technological milestones matter, detailed focus should be on cultural shifts to help explain why outreach is a central pillar of astrosci culture 2. Alongside. Interested in nonobvious or subtle causes. Err on the side of TMI. 3. Global. 4. Both. Provide summary answer for "why".

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 04/02/2025

Starting @ the Zeiss Mark 1 projector, provide a comparative timeline of development of science outreach and visualization between astrophysics and neuroscience fields over the past century. Highlight key major discoveries, world events, policy choices and outreach efforts to explain the disparity

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Reposted by Tyler Sloan @Quorumetrix Studio

wabniklab.bsky.social @wabniklab.bsky.social · 03/02/2025

Our lab is looking for a enthusiastic researcher with the master degree (Computational Biology, Computer Science, Game development) to develop next-gen computer games to model organ development in 4D. If you are interested drop me an email: k.wabnik@upm.es

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Reposted by Tyler Sloan @Quorumetrix Studio

Patrick Mineault @patrickmineault.bsky.social · 30/01/2025

I'm surprised when I hear that people still don't find mundane utility in LLMs. I'll mention two simple things: Perplexity Pro will read several websites and generate essays with 10+ citations leveraging papers and industry websites. Immensely useful compared to regular search 1/

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 17/01/2025

I was most happy with how the #synapse scene turned out, using the #neurons as a holdout for the pre and post synapse volume densities with distance out of focus. To answer nobody's burning question, yes I was thinking about the Mind Flayer (Stranger Things) the entire time.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 17/01/2025

I really enjoyed making this #neuro #visualization for @e11bio.bsky.social last November. A pleasure working with them, the entire way through. I'm really excited to see their technology scale up.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 17/01/2025

Thanks! Purkinje's drawing reminds me of the Hitchcock silhouette. Maybe Deiters could better be described as the first accurate rendering.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 16/01/2025

I was doing some research for a lecture I'm putting together and TIL that these may be the first ever drawings of #neurons by Otto Deiters published posthumously c1865. Anyone know of drawings that pre-date these? #neuroscience #history

Early renderings of neurons in spinal cord c1865

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Reposted by Tyler Sloan @Quorumetrix Studio

John Tuthill @tuthill.bsky.social · 19/12/2024

my lab (www.tuthill.casa) at UW is hiring a research assistant/tech. basic scope is to apply machine learning/computer vision tools to measure and model 3D animal behavior and mechanics. we are a diverse, collaborative, curiosity-driven group. Apply: uwhires.admin.washington.edu/ENG/Candidat...

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 31/12/2024

Happy New Year everyone! Here's a mashup of some of my favorite clips from this year, set to old-timey ragtime piano. I hope you enjoy having this song stuck in your head as much as I do. youtu.be/saRTncoe5uk

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2024 Highlight Reel Quorumetrix Studio

YouTube video by Quorumetrix Studio

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Reposted by Tyler Sloan @Quorumetrix Studio

The Transmitter @thetransmitter.bsky.social · 16/12/2024

The cortex is filled with excitatory local synapses, but we know little about their role in brain function. New experimental tools, along with ideas from artificial intelligence, are poised to change that. By @markhisted.org www.thetransmitter.org/neural-netwo...

thetransmitter.org

What are recurrent networks doing in the brain?

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 21/11/2024

"In the Eye of a Fly": Connectome spiking neural activity simulation. Explores: - Topographic mapping in the #drosophila optic lobe - Connectome informed spiking simulations (with Brian2) #sciviz #dataviz #neurosience www.youtube.com/watch?v=HjpZ...

youtube.com

In the Eye of a Fly: Connectome spiking neural activity simulation

YouTube video by Quorumetrix Studio

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Reposted by Tyler Sloan @Quorumetrix Studio

The Transmitter @thetransmitter.bsky.social · 08/07/2024

Tyler Sloan discusses why neuroscience needs to overcome its legacy of minimalism and embrace the contemporary challenge of representing whole-nervous-system connectivity. By @quorumetrix.bsky.social www.thetransmitter.org/connectome/t...

thetransmitter.org

To develop better nervous-system visualizations, we need to think BIG

With a full mouse connectome on the horizon, neuroscience needs to overcome its legacy of minimalism and embrace the contemporary challenge of representing whole-nervous-system connectivity.

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Tyler Sloan @Quorumetrix Studio @quorumetrix.bsky.social · 16/02/2024

A #neuro #data #visualization: An intuition pump on information processing in the #brain. ~75K #neurons in the #MICrONS mm³. I/O segregated by layers, function is columnar; the cortical column is the unit of cortical computation. A typical #Pyramidal cell has over >10K input synapses.

youtu.be

A Cubic Millimeter of Mouse Brain

My latest #neuro #visualization is an intuition pump to help us appreciate the intricate interconnectivity of cells in your #brain. We begin by peeling thro...

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