iiinova — where your digital self keeps evolving

Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

The position is well considered and I’ve been arguing it forever — timeliness matters for discussion

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

Arxiv IS a different channel than journals

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

Agree with the smoothing thing. I just likely never would have gotten it out so that is the counterfactual. I like that it allows talking about it instead of not — though unfortunately so far only the manner not yet the substance

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

No! I am definitely not here. I blame Richard for this

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

What if improved sequencing technologies caused people to say remember how hard we had to work to sequence a single gene? We’re going to limit how many sequences you can deposit in public repos because there can be no conceivable reason to get science out other than credit/recognition

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

Yes it’s different but not devoid of reflective thinking in the iterative process and my manual editing of the output. The biggest loss in my estimation is the polished output is decidedly less pointed/sharp and more generous than my raw input. So it may be less fun to read but not less considered

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

Making assumptions about the necessary absence of human involvement and responsibility in AI-assisted science might make people feel more virtuous and relevant but it’s a straw man. Also gating progress just because it’s fast is a terrible idea and an irresponsible throttling of science

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

I’m not advocating for randomly increasing publication output anywhere. I’m saying that gating it is stupid when bottlenecks have been removed that usefully accelerate many aspects of science. Slower human contingent slop isn’t better because it’s human

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

this is ridiculous, the input was a ton my ideas and words. None of the ideas are generated by AI. Then AI polish, then editing where it deviated. And the delicious irony is the people turning off their brains to be unable to grapple with ideas when AI is mentioned.

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

It’s not that far off. Much if the language is stuff I’ve said on twitter and elsewhere many times. Why does it matter? It’s what I believe. Here’s the human written view: arxiv has lost the thread and isn’t up to the task of their current role. Real Prachee is a bigger asshole than Claude

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Prachee Avasthi @pracheeac.bsky.social · 03/10/2026

This isn’t science … it’s taking a long rant and turning it into a written format for the internet (that I edited and agree with). It’s borderline misconduct to abdicate judgement to proxies

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Prachee Avasthi @pracheeac.bsky.social · 21/08/2026

Given the scope of this role overseeing basic, translational, and clinical research as well has having strategic vision across infrastructure, training, and improving scientific reproducibility, this recruitment has indirect impact reaching into other sectors and across the world. 3/

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Prachee Avasthi @pracheeac.bsky.social · 21/08/2026

“At a time when how science is conducted, shared, and consumed is rapidly changing, NIH seeks a bold, visionary leader prepared to drive transformative change, harness emerging technologies, modernize the research enterprise, and build the scientific workforce and capabilities needed ...” 2/

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Prachee Avasthi @pracheeac.bsky.social · 21/08/2026

Here’s a hugely important vacancy at the NIH at a critical moment of technological and scientific change. The NIH is looking for a deputy director of intramural research. 1/

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Prachee Avasthi @pracheeac.bsky.social · 20/04/2026

I have very confidence we’ll solve all the things (or at least have fun trying)!

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Reposted by Prachee Avasthi

Arjun Krishnan @compbiologist.bsky.social · 13/04/2026

What is the PhD actually for, especially now that AI can do increasingly more of what we train scientists to do? compbiologist.substack.com/p/what-is-th... A response to @pracheeac.bsky.social's thought-provoking essay "Free the PhD".

compbiologist.substack.com

What is the PhD actually for?

A response to Prachee’s “Free the PhD”, and a critique of my own work

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Prachee Avasthi @pracheeac.bsky.social · 14/04/2026

I hope more people engage and shape the future with more curiosity than fear

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Prachee Avasthi @pracheeac.bsky.social · 14/04/2026

Great read! Thanks for digging deep into this, which I think is far more valuable than anyone’s hot take! What a great time to grapple with and reimagine what’s possible

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Prachee Avasthi @pracheeac.bsky.social · 30/03/2026

Hah! That was a long time ago … but still true!

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Prachee Avasthi @pracheeac.bsky.social · 13/01/2026

New job alert! If you're passionate about open science, organized, enthusiastic about meeting new people doing exciting work in this space, and want to nerd out with me on all the ways we can move the needle on open science @asterainstitute.bsky.social, apply now! jobs.ashbyhq.com/astera/f085e...

jobs.ashbyhq.com

Open Science Operations Associate

Join Astera as an Open Science Operations Associate! Support open science programs, connect with researchers, and help accelerate scientific progress. In-person, based in Emeryville, CA.

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Reposted by Prachee Avasthi

Michael Hoffman @michaelhoffman.bsky.social · 12/01/2026

The "my competitor will see my preprint and replicate/rush their story to a journal" = their competitor has to have already done at least the rate-limiting parts of the work. To me, this is about someone wanting to receive exclusive credit for work that other groups were doing simultaneously.

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Prachee Avasthi @pracheeac.bsky.social · 11/01/2026

Right on. Get rid of the riff raff. The humorless of today is the reply guy of tomorrow

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Reposted by Prachee Avasthi

Michael Hoffman @michaelhoffman.bsky.social · 10/01/2026

What genetic change to Indian wheat led to superior baking in a tandoor? A naan sense mutation

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Prachee Avasthi @pracheeac.bsky.social · 07/11/2025

After working closely together across two open science orgs over the last 7+ years, I’ll really miss working with @jessicapolka.bsky.social. She’s a total pro, an exceptional operator, a sharp strategist, and just a fantastic human ❤️. Really excited to see all she does next!

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Prachee Avasthi @pracheeac.bsky.social · 07/11/2025

the poor generalizability of any model output certainly is a function of the structure and redundancy of the training data but i think the greater point here is that human performance isn’t the aspirational goal

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Prachee Avasthi @pracheeac.bsky.social · 04/11/2025

Spoke recently to the great folks at the science foundation on their efforts to fund curiosity-driven science. They have a new RFA out for catalytic awards (up to $10K). Take a look if you’re itching to expand or try out a new idea. science-foundation.org

science-foundation.org

Public Science, Public Good – Public Science, Public Good

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Prachee Avasthi @pracheeac.bsky.social · 22/10/2025

ICYMI: the deadline to nominate a publishing trailblazer so we can amplify their efforts is October 31!

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Reposted by Prachee Avasthi

SPARC @sparcopen.bsky.social · 21/10/2025

ICYMI: Read our impact story on policies at HHMI, Gates & Astera promoting #OpenAccess #OpenScience #OpenData. Thought leaders helping accelerate discovery in science @madubs.bsky.social @openaccessmaven.bsky.social @pracheeac.bsky.social! sparcopen.org/impact-story...

sparcopen.org

Funders Roll Out Next Gen Open Policies - SPARC

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Reposted by Prachee Avasthi

Prachee Avasthi @pracheeac.bsky.social · 16/10/2025

We have a bunch of new job ads out @arcadiascience.com. If you haven’t checked them out, take a look! www.arcadiascience.com/careers

arcadiascience.com

Careers | Arcadia Science

Evolve with Arcadia.

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Prachee Avasthi @pracheeac.bsky.social · 16/10/2025

We have a bunch of new job ads out @arcadiascience.com. If you haven’t checked them out, take a look! www.arcadiascience.com/careers

arcadiascience.com

Careers | Arcadia Science

Evolve with Arcadia.

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Reposted by Prachee Avasthi

Ronen Tamari @ronentk.me · 15/10/2025

1/ 📢 New blog post! @pracheeac.bsky.social recently wrote a great piece about the need for paradigm shifts in science communication: “Stop building faster horses when we need fundamentally different vehicles.” 🧵https://bsky.app/profile/pracheeac.bsky.social/post/3m2exwtn6o22i

bsky.app

Prachee Avasthi (@pracheeac.bsky.social)

New Blog Post: Scholarly Communication Is a Research Problem. This Means You. https://pracheeac.substack.com/p/scholarly-communication-is-a-research

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Prachee Avasthi @pracheeac.bsky.social · 15/10/2025

If you’re a PhD scientist with technical skills spanning these areas and also have project/people management experience, I’m looking for you! Apply now, or if you know someone else that would be a good fit, kindly pass along the job ad below! 👇 jobs.lever.co/arcadiascien...

jobs.lever.co

Arcadia Science - Project Director

A Bit About Us We are Arcadia Science, an evolutionary biology company founded and led by scientists. Our mission is to turn natural innovations into real-world solutions by developing systematic and ...

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Prachee Avasthi @pracheeac.bsky.social · 15/10/2025

🚨New job alert! We’re trying to put some tailwind behind developing out some of our new molecular, organismal, and high dimensional phenotyping capabilities @arcadiascience.com and are launching an effort to fuel the fire. But first I need a project director to oversee it.

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Prachee Avasthi @pracheeac.bsky.social · 10/10/2025

Yes absolutely. It is just post publication peer review rather than gated by it. It’s even better if the peer review is public. Funding always involves peer review as well and journal stamps are terrible proxies and inferior to more substantive vetting regardless

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Prachee Avasthi @pracheeac.bsky.social · 10/10/2025

Waiting for incentives to change in scientific publishing? We’ve got you! I hope other funders follow suit to make the most of their research dollars

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Prachee Avasthi @pracheeac.bsky.social · 10/10/2025

Must have had a typo or something but they reposted … will repost myself too

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Reposted by Prachee Avasthi

Prachee Avasthi @pracheeac.bsky.social · 08/10/2025

Some scientists aren’t waiting for journals to catch up. They’re showing us what’s next. The Beyond the Journal awards honor those breaking the mold in how science is shared. More details: pracheeac.substack.com/p/off-roadin... Nominate or self-nominate here: www.experiment.foundation/beyond

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Prachee Avasthi @pracheeac.bsky.social · 08/10/2025

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Reposted by Prachee Avasthi

Prachee Avasthi @pracheeac.bsky.social · 04/10/2025

New Blog Post: Scholarly Communication Is a Research Problem. This Means You. pracheeac.substack.com/p/scholarly-...

pracheeac.substack.com

Scholarly Communication Is a Research Problem. This Means You.

Scholarly Communication Is a Research Problem.

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