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Phase Genomics

@phasegenomics.bsky.social
231 followers 15 following 114 posts

Blueprints for Biology™: Genomics, Metagenomics, Cytogenomics | ProxiMeta™ Metagenome Deconvolution | Proximo™ Genome Scaffolding | Hi-C Kits |

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Phase Genomics @phasegenomics.bsky.social · 22/09/2026
Every Phase Genomics Proximo™ or ProxiMeta™ Hi-C kit now comes with PGShield™, our buffer for room-temperature preservation that keeps samples Hi-C-ready for months. No cold chain. No culturing. Swipe through for more on the power of PGShield.
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Phase Genomics @phasegenomics.bsky.social · 08/09/2026
Tune in to a new on-demand deep dive from Labroots and Phase Genomics CEO @ivanliachko.bsky.social on how Hi-C metagenomics connects fragmented DNA and reveals relationships among phages, plasmids, and other MGEs in the microbiome. You’ll find Ivan’s talk here: www.labroots.com/ms/webinar/l...
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Phase Genomics @phasegenomics.bsky.social · 18/08/2026
Look for Phase Genomics CEO @ivanliachko.bsky.social at #ISME20 this week. He’ll join a special session exploring the translation of microbiome science into commercial applications. You’ll find the session, MS25: Microbiome-Based Products, in room 516 on 8/21 starting at 10:30 am local time.
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Phase Genomics @phasegenomics.bsky.social · 29/05/2026
Catch us at a conference: Ivan Liachko takes the stage at FutureinReview on 6/1 for a panel called “Gut Feeling: Hacking Your Microbiome”. Later that week, from 6/4 to 6/7, he’ll be on the ground at ASM Microbe 2026 in DC. Say “hey 👋” and connect for the latest in Hi-C!
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Phase Genomics @phasegenomics.bsky.social · 29/04/2026
Breeding is supposed to narrow diversity. A new hexaploid oat pangenome in @nature.com shows that's not the whole story. HiFi + Hi-C across 30+ lines revealed breeders have been adding structural diversity all along. Jeff Maughan, PhD, breaks it down in the clip below:
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Phase Genomics @phasegenomics.bsky.social · 22/04/2026
The biggest sustainability challenges are rooted in biology we’re still learning to understand. Hi-C helps build better genomes and unravel microbial communities that support healthier soils, stronger crops, and more resilient ecosystems. Happy 🌎 Day from Phase Genomics.
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Phase Genomics @phasegenomics.bsky.social · 15/04/2026
Long reads get you contigs. Proximo™ Hi-C Kits for Plants get you chromosomes you can put to work or meaningful trait / QTL mapping and functional analysis. Tell us about your research and take 20% off through May 1👇 info.phasegenomics.com/hi-c-plant-g...
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Phase Genomics @phasegenomics.bsky.social · 08/04/2026
One oat line has more structural variation than a panel of wheat lines. That finding, from the 1st chromosome-scale oat assembly, led to a 30-line hexaploid oat pangenome published in @nature.com using HiFi + Hi-C. Full breakdown from senior author Jeff Maughan, PhD, in the clip below:
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Phase Genomics @phasegenomics.bsky.social · 01/04/2026
Your research budget just got a little more room to grow. Take 20% off Proximo™ Hi-C Kits for plant genomics until May 1st. Hi-C unlocks chromosome-scale insights from your long reads. Get started here 👇 info.phasegenomics.com/hi-c-for-plants
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Phase Genomics @phasegenomics.bsky.social · 25/03/2026
New in the Journal of Water and Health: ProxiMeta™ Hi-C metagenomics improves antimicrobial resistance tracking in wastewater. Key findings: → 2,816 traits detected → 554 genes linked to hosts → 52.9% of genes were ARGs 🔗 iwaponline.com/jwh/article/...
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Phase Genomics @phasegenomics.bsky.social · 11/03/2026
32% off ProxiMeta™ Hi-C kits ends 3/15 (then save 16% through end of month). You’ll get: ✅ High-quality MAGs from complex samples ✅ More complete genomes than traditional binning ✅ Accurate host attribution for phages, plasmids, and AMR genes 👉 info.phasegenomics.com/march-magness
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Phase Genomics @phasegenomics.bsky.social · 04/03/2026
March MAGness is here! Score special pricing on ProxiMeta™ Hi-C kits for metagenomics & microbiome studies in everything from complex soil samples, to gut microbiomes, to bioreactors: 🔬 32% off | March 2–15 🔬 16% off | March 16–31 Get started here 👇 info.phasegenomics.com/march-magness
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Phase Genomics @phasegenomics.bsky.social · 03/03/2026
FISH finds what it's looking for, and only what it's looking for. In a new study in @AjHematologyshows, Hi-C confirmed FISH findings, plus chromothripsis, CN-LOH & complex rearrangements that FISH probes can’t pinpoint. 🔗https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.70219
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Phase Genomics @phasegenomics.bsky.social · 19/02/2026
New Nature Plants study using Proximo™ Hi-C shows how a hybrid eelgrass species inherited low-light tolerance genes from its deep-water parent that could change how we approach coastal restoration. More from Todd Michael, PhD & team at @salkinstitute.bsky.social l 📄 www.nature.com/articles/s41...
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Phase Genomics @phasegenomics.bsky.social · 11/02/2026
New Publication in @plosbiology.org: Optimized Hi-C analysis (Z-score filtering) boosts specificity & reveals virus-host interactions using Phase Genomics’ ProxiMeta™ Hi-C: 79 genus-level matches + 293 new linkages in well-studied, climate-critical soils. journals.plos.org/plosbiology/...
journals.plos.org
Benchmarking with synthetic communities provides a baseline for virus-host inferences from Hi-C proximity linking
Virus discovery has accelerated but linking viruses to hosts remains challenging. This study uses synthetic microbiomes to optimize and benchmark Hi-C for virus-host linkage inference, and applies thi...
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Phase Genomics @phasegenomics.bsky.social · 03/02/2026
"A year and a half ago, we couldn't have resolved this hybrid genome." New tech (long reads + Hi-C) let researchers separate parental haplotypes in eelgrass revealing which genes drive low-light tolerance. Todd Michael, PhD breaks down how:
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Phase Genomics @phasegenomics.bsky.social · 29/01/2026
Phase Genomics IRL: a few days together in Portland for real-time collab & creativity. Aligning on new products, pressure-testing ideas, a little fun behind the wheel. It’s how we build even better Hi-C tools for the researchers who rely on them. A few of our favorite moments👇
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Phase Genomics @phasegenomics.bsky.social · 28/01/2026
Tissue prep drives variability early in Hi-C workflows. A new STAR Protocol adds cryogenic tissue grinding before crosslinking, with safe pause points for optimized lab workflows. See how it improves reproducibility & library quality → star-protocols.cell.com/protocols/4702
star-protocols.cell.com
Cell Press: STAR Protocols
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...
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Phase Genomics @phasegenomics.bsky.social · 15/01/2026
Wheels up ✈️ Our CEO Ivan’s headed to Newport Beach for Microbes in Wastewater. He’ll show how ProxiMeta™ links microbes, phages & the mobilome to track #AMR in wastewater. No coding. Just discovery. If you’ll be in Newport for the conference, say hi to @ivanliachko.bsky.social
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Phase Genomics @phasegenomics.bsky.social · 08/01/2026
We heard you. Our 25 in ’25 promo is extended through Jan 16. Save 25% on Phase Genomics Hi-C kits via direct order, book a complimentary bioinformatics consult, and access discounted full-service ProxiMeta™ packages. Get started → info.phasegenomics.com/25-in-25
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Phase Genomics @phasegenomics.bsky.social · 04/12/2025
Bees carry more than nectar. Their gut microbiomes buzz with plasmids, sharing tetracycline resistance genes across hives. Chris Robinson, PhD from Irene Newton, PhD’s lab used Hi-C to track these mobile elements & explore colony-specific patterns traditional metagenomics misses.
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Phase Genomics @phasegenomics.bsky.social · 01/12/2025
Stuck on Hi-C data? First 25 researchers to email get a free consult with our computational scientists—whether you're using our kits or another provider's. Email info@phasegenomics.com with "25 in '25 Bioinformatics Promo" in the subject line to claim yours.
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Phase Genomics @phasegenomics.bsky.social · 25/11/2025
Save 25% on Hi-C kits through Dec 31. From complex plant genomes to metagenome binning, Phase Genomics brings clarity to your toughest research questions. Email info@phasegenomics.com with "25 in '25 Kit Promo" in the subject line to claim your discount.
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Phase Genomics @phasegenomics.bsky.social · 18/11/2025
🌿 Scientists produced a high-quality, chromosome-scale genome for American pickleweed, a salt-loving, tetraploid marsh plant. With ~80k genes and detailed methylation data, this resource paves the way for understanding salt-tolerance & supporting salt-marsh conservation. 🔗 bit.ly/3XAQ7vT
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Phase Genomics @phasegenomics.bsky.social · 12/11/2025
New at #AMPath2025: He Fang, PhD, will showcase Genomic Proximity Mapping® (GPM) and CytoTerra® in #sarcoma. Stop by Level 2, 258ABC on 11/13 from 2:30 – 3:30 pm ET to discover how GPM uncovers hidden structural variants and mosaicism in challenging archival samples.
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Phase Genomics @phasegenomics.bsky.social · 06/11/2025
🌿 New in @NaturePlants! Researchers used Phase Genomics’ Hi-C to build a haplotype-resolved chromosome-scale #genome of a hybrid eelgrass (Zostera marina × Z. pacifica), revealing genomic clues to low-light tolerance that could boost coastal restoration. www.nature.com/articles/s41...
nature.com
Hybridization and low-light adaptability in California eelgrass (Zostera spp.) - Nature Plants
Seagrass genomes of the deep-water Zostera pacifica and shallow-water Z. marina from the Eastern Pacific Ocean provide evidence for low-light adaptation exemplified in the wild hybrid Z. marina × paci...
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Phase Genomics @phasegenomics.bsky.social · 04/11/2025
Big spotlight on Genomic Proximity Mapping® (GPM®) from Elsevier's JMD: See how UW researchers use our GPM platform, CytoTerra®, to detect cryptic structural variants and mosaicism missed by standard tests. Full press release from @elsevierconnect.bsky.social: www.elsevier.com/about/press-...
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Phase Genomics @phasegenomics.bsky.social · 30/10/2025
Phase Genomics Hi-C helped untangle the pomegranate genome, ordering contigs into chromosome-scale scaffolds, clarifying chromosome counts & revealing domestication patterns. Full study from the Volcani Center: link.springer.com/article/10.1...
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Phase Genomics @phasegenomics.bsky.social · 28/10/2025
Phase Genomics’ Hi-C tech helped undergrads assemble the “best duckweed genome yet,” giving them hands-on research experience, boosting PhD prospects, and advancing plant biology. Full story from Alex Harkess at HudsonAlpha on YouTube: na2.hubs.ly/H01P7mG0
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Phase Genomics @phasegenomics.bsky.social · 23/10/2025
Hi-C at scale is reshaping plant biology. With Phase Genomics’ kits, Alex Harkess & HudsonAlpha have published dozens of genomes, uncovered how rising CO₂ alters chromatin structure, and explored how climate change ripples through living systems. 🔗 youtu.be/5-Ub7FnpHzs?...
youtu.be
Hi-C in Action: Faster Discoveries, More Publications, Bigger Impact | with Alex Harkess
YouTube video by Phase Genomics
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Phase Genomics @phasegenomics.bsky.social · 22/10/2025
Happy #WorldPhageDay. Tiny, abundant, and anything but boring, phages shape microbial communities, move genes around, and can tip the balance in all kinds of ecosystems. The catch: to know a #phage only you must know its host. ProxiMeta Hi-C technology gives us that link.
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Phase Genomics @phasegenomics.bsky.social · 21/10/2025
🌳 New chromosome-level Ulmus minor (field elm) genome unlocks clues to Dutch elm disease resistance. Using long reads and Hi-C, the team built this 2.1Gb genome and mapped clusters of resistance genes conserved across elm species to aid restoration. na2.hubs.ly/H01HQ2Q0
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Phase Genomics @phasegenomics.bsky.social · 09/10/2025
ProxiMeta™ Hi-C fills the missing link in shotgun metagenomics, connecting viruses to hosts & revealing hidden microbial relationships. Hear more from Phil Hugenholtz & Phase Genomics CEO Ivan Liachko on how Hi-C unlocks the microbiome → www.youtube.com/watch?v=DYMv...
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Phase Genomics @phasegenomics.bsky.social · 07/10/2025
Skip the computational guesswork. Hi-C / proximity ligation reveal complete chromosomal architecture based on actual intracellular contacts. From plant genomes to metagenomes, Phase Genomics delivers chromosome-scale assemblies traditional methods can’t: phasegenomics.com/resources-an...
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Phase Genomics @phasegenomics.bsky.social · 29/09/2025
In this great new paper, the authors use metagenomic Hi-C to show that #phage with broad host range are fairly common, contrary to the prevailing view on their biology. Cutting edge methods like Hi-C are shedding light on our blind spots in the microbial world.
nature.com
Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
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Phase Genomics @phasegenomics.bsky.social · 23/09/2025
ProxiMeta™ turns your benchtop box into a Hi-C metagenomics powerhouse. Order before Sept. 30 to lock in 20% savings on the 8-sample ProxiMeta Classic Hi-C Kit, or 50% on the 2-sample ProxiMeta Starter Hi-C Kit. 🔗https://phasegenomics.com/contact-us/
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Phase Genomics @phasegenomics.bsky.social · 16/09/2025
Don’t let your lab’s grant dollars go to waste. Order before September 30 to save 20% on ProxiMeta™ Classic Hi-C Kit, or 50% on the ProxiMeta Starter Hi-C Kit. ✔️ Hands-off workflow ✔️ Flexible timelines ✔️ PGShield™ to keep samples shelf-stable 🔗https://phasegenomics.com/contact-us/
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Phase Genomics @phasegenomics.bsky.social · 11/09/2025
Join us at the Microbiome Innovation One Health Conference in Oxford on Sept 15! @ivanliachko.bsky.social will present how ProxiMeta™ maps microbes, viruses, plasmids & resistance genes, bringing clarity to complexity across human, animal and environmental health.
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Phase Genomics @phasegenomics.bsky.social · 04/09/2025
🧬 Important Slug News! Researchers assembled a chromosome-scale #genome for Deroceras laeve using Proximo Hi-C and @pacbio.bsky.social - making it a useful model for study of #genomics, #evolution, and slimyness... Congrats to Alfredo Varela-Echavarría & team! 🔗 academic.oup.com/g3journal/ad...
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Phase Genomics @phasegenomics.bsky.social · 21/08/2025
A fungus among us: Proximo Hi‑C + @pacbio.bsky.social HiFi produced telomere‑to‑telomere genomes for VCG‑01111/01112, uncovering 4 accessory chromosomes, >3.6 My divergence, SIX6 and novel effectors—pinpointing drivers of high virulence. www.mdpi.com/2309-608X/11...
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Phase Genomics @phasegenomics.bsky.social · 19/08/2025
Stanford researchers just achieved another 1st: Using ProxiMeta™, helped isolate p-crAssphage, a common gut virus and shape shifter that can switch between producing viruses and quietly living in bacteria like a plasmid. Read more in @cp-cellhostmicrobe.bsky.social: www.cell.com/cell-host-mi...
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Reposted by Phase Genomics
Ivan Liachko @ivanliachko.bsky.social · 12/08/2025
New study uses long-read + @phasegenomics.bsky.social Hi-C to assemble chromosome-scale #genome of Trichomonas vaginalis and bird-infecting relatives, revealing key genes tied to bird-to-human spillover. Congrats to Jane Carlton, ‪@mikeschatz.bsky.social‬ and team!
nature.com
Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans - Nature Communications
The sexually transmitted human parasite Trichomonas vaginalis belongs to a clade of host-switching trichomonads that parasitize mammals, birds, livestock, and pets. Here the authors describe a chromos...
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Phase Genomics @phasegenomics.bsky.social · 06/08/2025
Structural variants often go undetected by traditional cytogenetics. A new review in Genes shows how Genomic Proximity Mapping™ (GPM) detects complex SVs right from FFPE. Read more Dr. Patrick Gonzales at the University of Kansas Medical Center: www.mdpi.com/2073-4425/16...
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Phase Genomics @phasegenomics.bsky.social · 05/08/2025
Scenes from #CGC2025: Min Fang, MD, PhD at Fred Hutch shared how Genomic Proximity Mapping™ (GPM) powers her next-gen cytogenomic analysis in AML. If you’re at #CGC2025 this year, stop by booth 23 to speak with the Phase Genomics team about how #GPM can accelerate your research!
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Phase Genomics @phasegenomics.bsky.social · 04/08/2025
When sample quality is low, insight usually is too. Not with Genomic Proximity Mapping™ (GPM). Phase Genomics’ GPM works on #FFPE and mosaic samples. It’s just one assay, no metaphase prep, and no tradeoff in resolution. A new preprint shows how: www.medrxiv.org/content/10.1...
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Phase Genomics @phasegenomics.bsky.social · 01/08/2025
Comprehensive cytogenetics from any sample type—including #FFPE—in just one assay: CytoTerra® delivers genome-wide SV detection with no culture, no HMW DNA, and results in as little as 5 days. Stop by booth 23 & check out our presentations to see it in action at #CGC2025.
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Phase Genomics @phasegenomics.bsky.social · 28/07/2025
A major advance in the field of human #genetics and #cancer #genomics! As always, we are proud to have been able to contribute our small part to this huge undertaking. 🧬 130 haplotypes, many T2T 🧬 Closed 92% of assembly gaps 🧬 1,852 complex SVs 🧬 1,246 centromeres www.nature.com/articles/s41...
nature.com
Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
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Phase Genomics @phasegenomics.bsky.social · 25/07/2025
🌸 Chromosome-scale genome of Petunia hybrida assembled with Proximo Hi-C, PacBio HiFi, Illumina & Bionano. 7 pseudochromosomes, 99.8% BUSCO with Hi-C being key for resolving repeats. A powerful resource for Solanaceae genetics & breeding. #genome #HiC 📄 hubs.la/Q03ypPmb0
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Phase Genomics @phasegenomics.bsky.social · 23/07/2025
Introducing PGShield™ - our new room-temperature sample solution for Hi-C. No more dry ice shipments. Improved data quality and library yields. Store your samples for months without sacrificing data quality. Get a FREE 10mL bottle today! #genomics #HiC 🔗https://hubs.la/Q03yhGWf0
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