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Periklis Paganos

@perievodevo.bsky.social
164 followers 183 following 46 posts

I’m a Researcher @szndohrn.bsky.social and I use echinoderms as experimental systems to investigate the evolution of cell types and organs. 🌊⭐️🦔

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Reposted by Periklis Paganos
Christopher B. Cameron @invertevo.bsky.social · 11/09/2026
Single-cell transcriptomes of acorn worms show that larval & adult body plans are composed of distinct cell types. Larval & adult cells evolve quasi-independently! @paulbump.bsky.social @laurentformery.bsky.social @lowelab.bsky.social @planaria1.bsky.social www.nature.com/articles/s41...
nature.com
Distinct cell states define larval and adult body plans in a hemichordate - Nature Communications
Here they use scRNA-seq to show that, in the hemichordate Schizocardium californicum, ectoderm and endoderm shift transcriptional identity from larva to adult while mesoderm is transcriptionally conserved, making life stage a major axis of cellular state.
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Periklis Paganos @perievodevo.bsky.social · 03/09/2026
Congratulations Laurent!!! Amazing news! Well-deserved!!!🥂
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Reposted by Periklis Paganos
Laurent Formery @laurentformery.bsky.social · 03/09/2026
Fantastic news!!! My project ECHINODEV has been awarded an ERC starting grant 🥳🥳⭐ We will use several echinoderm species to study animal body plan evolution! Reach out if you are interested, we will be looking for PhD students and postdocs 😀
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Andreas Hejnol @hejnol.bsky.social · 27/07/2026
Good to see our results from xenacoelomorphs (doi.org/10.1038/s415...) made it into the new BBC "Evolution" documentary! www.youtube.com/watch?v=tgjZ...
doi.org
Molecular evidence from xenacoelomorph gonopore formation supports homology with the bilaterian anus - Nature Ecology & Evolution
The evolutionary origin of the bilaterian gut with two openings is debated. Expression in xenacoelomorphs, the sister group to bilaterians, of genes involved in bilaterian gut patterning suggests that...
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Reposted by Periklis Paganos
ZooCELL MSCA-Doctoral Network @zoocell.bsky.social · 21/07/2026
🔬 Meet Michalis Averof, ZooCELL PI at IGFL @michalis-averof.bsky.social What sparked his interest in EvoDevo? What keeps him curious after all these years? And what does he hope to discover next? 🧵 Read on to get to know Michalis through his own words. #ZooCELL#EvoDevo#genomics#IGFL#MSCA
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Reposted by Periklis Paganos
Maria Lorenza Rusciano @mlrusciano.bsky.social · 08/07/2026
Fantastic seminar by Chris @lowelab.bsky.social. It’s been a real pleasure having you at @szndohrn.bsky.social these days. With @arnonelab.bsky.social
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Reposted by Periklis Paganos
ZooCELL MSCA-Doctoral Network @zoocell.bsky.social · 30/06/2026
🔬 Meet Ina Arnone, ZooCELL PI at @szndohrn.bsky.social In this Q&A, she shares how she discovered EvoDevo, the big questions driving their research and her passion for mentoring the next generation of scientists. Follow the thread to learn more. 👇 #MSCA #ZooCELL #EvoDevo @arnonelab.bsky.social
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Periklis Paganos @perievodevo.bsky.social · 26/06/2026
Thanks!!!
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Reposted by Periklis Paganos
Roy Zang @cellulo-evo.bsky.social · 26/06/2026
Very excited to see our preprint on the monoaminergic signaling system in sponges (www.biorxiv.org/content/10.6...) featured by @qedscience.bsky.social. This highlights the importance of studying early-branching animals to piece together how the first animal cell types communicated with each other.
biorxiv.org
An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge
Chemical neurotransmission was a key animal innovation, enabling multicellular coordination of physiology and locomotion. Sponges are early-diverging animals that lack neurons and muscles, yet still c...
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
Thank you Pedro!😁
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
I am grateful to @buckinstitute.org
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
Together, our findings suggest that key ovarian cell types and components of reproductive neuroendocrine signaling have early deuterostome origins, some of which may predate the emergence of complex reproductive organs and neuroendocrine regulatory systems.
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
These neurons express GnRH, oxytocin/vasopressin, serotonin, and dopamine, and are closely associated with germ cell nests and developing oocytes expressing the corresponding receptors.
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
A key finding was the identification of an intrinsic ovarian nerve plexus containing neurons with molecular signatures reminiscent of vertebrate HPG-axis neuroendocrine cells.
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
We identified putative oogonial stem cells organized in germ cell nests, as well as multiple follicle cell populations with molecular similarities to vertebrate granulosa and theca cells.
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
Using single-cell transcriptomics and high-resolution 3D imaging, we explored and mapped the ovarian cell type repertoire of the starfish Patiria miniata.
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Periklis Paganos @perievodevo.bsky.social · 25/06/2026
The paper from my postdoc days @mblscience.bsky.social and @zakswartz.bsky.social Lab is available in @natcomms.nature.com. www.nature.com/articles/s41... With Beverly Naigles, @carsten-wolff.bsky.social and @danivoronov.bsky.social
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Reposted by Periklis Paganos
Maurice Elphick @mauriceelphick.bsky.social · 24/06/2026
Published today in Open Biology, our investigation of the evolutionary and functional significance of neuropeptide cocktails. Congrats to my co-author Nayeli Escudero Castelán and thanks to @leverhulme.ac.uk and @ukri.org BBSRC for funding. royalsocietypublishing.org/rsob/article...
royalsocietypublishing.org
The evolution and functional significance of neuropeptide cocktails: insights from SALMFamides in asteroid echinoderms
Abstract. Neuropeptides derived from larger precursor proteins are neuronal signalling molecules that regulate physiological processes and behaviour. Some
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Reposted by Periklis Paganos
genikhovich.bsky.social @genikhovich.bsky.social · 18/06/2026
Congratulations to @kremnyovs.bsky.social, @tclebedeva.bsky.social and @hejnol.bsky.social - this is a fantastic paper. www.nature.com/articles/s41... Very happy to have been part of this collaboration.
nature.com
A blastoporal organizer in a ctenophore - Nature
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
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Ctenophores Rock! @ctenophoresrock.bsky.social · 17/06/2026
What is the evolutionary origin of the organizer? New work from @kremnyovs.bsky.social, @tclebedeva.bsky.social & Hejnol Lab @uni-jena.de reports the blastopore lip of the #ctenophore Mnemiopsis leidyi, a member of the evolutionary sister group to all other metazoans, exhibits organizer activity.
nature.com
A blastoporal organizer in a ctenophore - Nature
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
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Reposted by Periklis Paganos
preLights @prelights.bsky.social · 02/06/2026
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome. 🧬 Panagiotis Giannios highlights a recent #preprint from @mirimiam.bsky.social & collaborators. #EvolutionaryBiology #preLight: prelights.biologists.com/highlights/e...
prelights.biologists.com
Evolutionary landscapes of zygotic genome activation across animals - preLights
61 species, 13 phyla, one simple geometric rule that appears to set when every embryo starts speaking through its own genome.
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Arnone Lab @arnonelab.bsky.social · 15/06/2026
(1/2) What a fantastic week for the Arnone Lab at #EED2026 in Glasgow! Our lab’s work was showcased through contributed talks by @perievodevo.bsky.social in S19 and @mlrusciano.bsky.social in S02, as well as an invited talk by Ina in S15.
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Pawel Burkhardt @pawelburkhardt.bsky.social · 23/05/2026
A fossil nervous system meets modern neurobiology. We found that a living comb jelly preserves neural architecture remarkably similar to those inferred from Cambrian fossils over 500 million years old 🤩. www.biorxiv.org/content/10.6...
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Development @dev-journal.bsky.social · 15/05/2026
Issue 8 is now complete! On the cover: Embryos of diverse animals & choanoflagellates expressing different fluorescent reporters, from a project to identify membrane-localising tags across diverse organisms. See the Techniques and Resources Article by Karapidaki et al. doi.org/10.1242/dev....
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Manuel Irimia @mirimiam.bsky.social · 20/04/2026
Do you want to know when your favorite species activates its genome? Just input its genome size (🧬 in bp) and egg volumen (🥚 in um3) here! ZGA_onset = -2.37 * log10(gDNA/EggVol) + 11.74
media.tenor.com
a cartoon of spongebob saying magic with his hands up
ALT: a cartoon of spongebob saying magic with his hands up
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Reposted by Periklis Paganos
Maria Lorenza Rusciano @mlrusciano.bsky.social · 19/04/2026
I am honored to have been involved in this super cool open-science project. Thanks, Michalis!
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Periklis Paganos @perievodevo.bsky.social · 20/04/2026
Thrilled to be part of this beautiful work! Stay tuned😉
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Arnone Lab @arnonelab.bsky.social · 15/01/2026
New findings on genomic regulation mechanisms throughout evolution | EurekAlert! www.eurekalert.org/news-release...
eurekalert.org
New findings on genomic regulation mechanisms throughout evolution
The conservation of genome regulatory elements over long periods of evolution is not limited to vertebrates, as previously thought, but also in echinoderms (invertebrates). This is one of the most not...
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Reposted by Periklis Paganos
RobertoFeuda @robertofeuda.bsky.social · 13/01/2026
Thrilled to share that I’ve been awarded a FIS-3 Advanced Grant (ERC-inspired) to study the evolution of neurogenic GRNs. Recruiting soon: 4 postdocs + 3 PhDs Press release in Italian — to decolonise scientific language 😄 magazine.unibo.it/it/articoli/... Email me if interested in joining the lab
magazine.unibo.it
Un viaggio all’origine dei sistemi nervosi
Il nuovo progetto GRNevo, finanziato con un grant FIS-3 Advanced da 1,9 milioni di euro, studierà come si formano i neuroni durante lo sviluppo in specie animali molto distanti tra loro: dal moscerino...
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Periklis Paganos @perievodevo.bsky.social · 12/01/2026
Coolness alert!! If you didn’t attend this fantastic microscopy course last year, make sure you do so this coming April! Don’t miss the chance to learn from the best in the field. Plus, the course takes place at @szndohrn.bsky.social, one of the most iconic marine stations in the world!
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Reposted by Periklis Paganos
Nikos Konstantinides @nkonst4.bsky.social · 10/01/2026
I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
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imaeso.bsky.social @imaeso.bsky.social · 07/01/2026
Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l
rdcu.be
Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes
Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...
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Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · 07/01/2026
Congratulations to the all team for this amazing work understanding how the cis regulatory elements and chromatin organization are relevant in the ancestral regulatory features of animal genomes. This study started with a collaboration with José Luís Gómez Skarmeta from #CABD.
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Dani Voronov @danivoronov.bsky.social · 07/01/2026
I am extremely proud and happy to announce that another paper from my PhD days has just been published in @natecoevo.nature.com on evolution of genome and gene regulation thanks to all the amazing people involved. Check the paper out at: www.nature.com/articles/s41...
nature.com
Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes - Nature Ecology & Evolution
Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms and the long-term evolutionary dynam...
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Periklis Paganos @perievodevo.bsky.social · 07/01/2026
Extremely happy to see this work out! I am deeply grateful to everyone who contributed, and especially to @danivoronov.bsky.social, who took the lead! @arnonelab.bsky.social sky is the limit! 🌊🔬🧬
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Periklis Paganos @perievodevo.bsky.social · 03/01/2026
When you combine a brilliant scientist with strong grant support, the result is magic. This is exactly what the NEF project will deliver, nothing less!
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Himmat Singh Bakshi @himmatbakshi.bsky.social · 01/12/2025
First #MicroscopeMonday contribution! Early auricularia larva of Holothuria tubulosa (4 days post-fertilisation, dpf) shown in brightfield (left) and with DAPI-stained nuclei (right, blue). Same larva. Same view. Bonus: this was also my first DAPI stain, imaged on an inverted microscope.
Two side-by-side microscope images of the same early auricularia larva (Holothuria tubulosa): brightfield on the left and DAPI-stained nuclei in blue on the right, with a 0.1 mm scale bar.
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Jérôme OLLIER @jeromeollier.bsky.social · 06/11/2025
Researchers discover an "all-body brain" in sea urchins - @mfnberlin.bsky.social www.museumfuernaturkunde.berlin/en/museum/me...
museumfuernaturkunde.berlin
Researchers discover an “all-body brain” in sea urchins
An international team of researchers, including scientists from the Museum für Naturkunde Berlin, has uncovered a surprisingly complex nervous system in sea urchins. The animals appear to possess an “...
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Periklis Paganos @perievodevo.bsky.social · 06/11/2025
Thank you!
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Periklis Paganos @perievodevo.bsky.social · 06/11/2025
Thanks a lot Uli!
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Periklis Paganos @perievodevo.bsky.social · 06/11/2025
Thank you! 😁
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Periklis Paganos @perievodevo.bsky.social · 06/11/2025
Thanks a lot Pedro!! 😁
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Periklis Paganos @perievodevo.bsky.social · 06/11/2025
Thank you Alison!
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Arnone Lab @arnonelab.bsky.social · 05/11/2025
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead! www.science.org/doi/10.1126/...
science.org
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
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Periklis Paganos @perievodevo.bsky.social · 05/11/2025
and in collaboration with @mfnberlin.bsky.social, Jack Ullrich-Lüter, Jil Carl, Maria Schauer, Anne-C. Zakrzewski, Berit Zemann, Carsten Lüter, @biodev-vlfr.bsky.social @croce-urchin.bsky.social, Tiphaine Sancerni, Oğuz Akar, @igflyon.bsky.social, @almazan.bsky.social #ScienceAdvancesResearch
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Periklis Paganos @perievodevo.bsky.social · 05/11/2025
With @szndohrn.bsky.social @danivoronov.bsky.social , @mlrusciano.bsky.social , @mariacocurullo.bsky.social, Filomena Caccavale, Giovanna Benvenuto
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Periklis Paganos @perievodevo.bsky.social · 05/11/2025
Long considered brainless creatures, our results provide evidence that sea urchins possess a highly photosensitive nervous system organized in an “all-brain” manner instead.
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Periklis Paganos @perievodevo.bsky.social · 05/11/2025
Adding to this complexity, we discovered a vast array of photoreceptor cells with a conserved retinal molecular fingerprint, as well as a population expressing a rare combination of opsins that we hypothesize is an ideal candidate for non-ocular sea urchin vision.
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Periklis Paganos @perievodevo.bsky.social · 05/11/2025
Moreover, we found that the postmetamorphic nervous system, remarkable for its cell type diversity and complexity, also exhibits a head-like molecular signature and expresses vertebrate brain gene homologs.
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Periklis Paganos @perievodevo.bsky.social · 05/11/2025
Based on our findings, we report that the sea urchin juvenile body plan is head-like, similar to what has previously been demonstrated in sea stars and brittle stars, suggesting that echinoderms in general are predominantly head-like organisms.
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