Paul Sample @paulsample.bsky.social · 22/08/2025openai.com/index/accele...openai.comAccelerating life sciences researchOpenAI and Retro Biosciences achieve 50x increase in expressing stem cell reprogramming markers. 050
Paul Sample @paulsample.bsky.social · 21/08/2025cloud.google.com/blog/product...cloud.google.comMeasuring the environmental impact of AI inference | Google Cloud BlogA methodology for measuring the energy, emissions, and water impact of Gemini prompts shines a light on the environmental impact of AI inference. 010
Paul Sample @paulsample.bsky.social · 08/07/2025Today would be a great day for the AI research community to leave X for good. In your own self interest and for the public perception of AI, take a stand. Unless you agree with using it as a misinformation and propaganda machine, I guess. 020
Reposted by Paul SampleAi2 @ai2.bsky.social · 01/07/2025Introducing SciArena, a platform for benchmarking models across scientific literature tasks. Inspired by Chatbot Arena, SciArena applies a crowdsourced LLM evaluation approach to the scientific domain. 🧵 1155
Paul Sample @paulsample.bsky.social · 12/06/2025Anthropic's Claude Code Python SDK just released? Currently sitting at 1 star! github.com/anthropics/c...github.comGitHub - anthropics/claude-code-sdk-pythonContribute to anthropics/claude-code-sdk-python development by creating an account on GitHub. 011
Reposted by Paul SampleAI x Bio Discovery @aixbiobot.bsky.social · 20/05/2025Robin: A multi-agent system for automating scientific discovery [new] Automating scientific discovery via a multi-agent system that integrates literature search and data analysis to propose/validate hypotheses. 001
Reposted by Paul SampleNicole Hennig @nic221.bsky.social · 14/05/2025Power-Hungry Data Centers Are Warming Homes in the Nordics bloom.bg/4jYABDI #AI #DataCenters #climate 043
Paul Sample @paulsample.bsky.social · 14/05/2025WhyTF would people use Grok when they do things like this? Not to mention the pollution they’re producing in Memphis. 010
Paul Sample @paulsample.bsky.social · 13/05/2025There is no bigger turn off to reading a paper than seeing the words “is all you need” in the title. 110
Paul Sample @paulsample.bsky.social · 10/05/2025Finally, the Twitter/X killer. Nothing quite as satisfying as operating in purely in a terminal. www.itter.shitter.shitter.sh - Social Media via SSHitter.sh: Ironic, text-only, SSH-based social networking for terminal lovers. No browser, no js, just eets. 000
Paul Sample @paulsample.bsky.social · 02/05/2025I always look forward to FutureHouse releases. I had to do a little digging for API information so here it is for those who are interested. futurehouse.gitbook.io/futurehouse-...futurehouse.gitbook.ioFutureHouse Platform API Documentation | FutureHouse Cookbook 041
Reposted by Paul SampleAngie Rasmussen @angierasmussen.bsky.social · 30/04/2025I knew he would do this. I wrote a whole article about how he would do this. I am not surprised he’s undermining vaccination. I know he’s an anti-vaxxer & a predatory crank. And yet…you have got to be fucking kidding me. He’s promoting infant mortality. 17644193
Reposted by Paul SampleAI x Bio Discovery @aixbiobot.bsky.social · 24/02/2025Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling [new] Atlas maps 50 cancer lines' trancriptomic response to 1.1k mols, aiding AI modeling. 111
Reposted by Paul SampleAI x Bio Discovery @aixbiobot.bsky.social · 22/02/2025Genome modeling and design across all domains of life with Evo 2 [new] Evo 2: Learns genomic features across life's domains from DNA alone and generates coherent, controllable genome sequences at scale. 021
Paul Sample @paulsample.bsky.social · 21/02/2025"Most baffling to many were the firings of hundreds whose jobs were not funded by taxpayers. Their positions were financed through congressionally approved agreements that routed fees from the drug, medical device and tobacco industries to the agency." 🤡 www.nytimes.com/live/2025/02...nytimes.comTrump Live Updates: Layoffs, Ukraine War and Deportation News 020
Reposted by Paul SampleKaren Hao @karenhao.bsky.social · 21/02/2025For decades, the US government has painstakingly kept American science #1 globally—and every facet of American life has improved because of it. The internet? Flu shot? Ozempic? All grew out of federally-funded research. Now all that's being dismantled. 1/ www.technologyreview.com/2025/02/21/1...technologyreview.comThe foundations of America’s prosperity are being dismantledFederal scientists warn that Americans could feel the effects of the new administration's devastating cuts for decades to come 7829991497
Paul Sample @paulsample.bsky.social · 04/02/2025Has anyone tried this? Struggling to find an information retrieval system I like. www.perplexity.ai/help-center/...perplexity.aiWhat is Internal Knowledge Search | Perplexity Help CenterInternal Knowledge Search allows both Perplexity Pro and Enterprise Pro users to search across internal files alongside the web. 050
Reposted by Paul SampleSimon Willison @simonwillison.net · 31/01/2025Severance obsessives like myself may be interested to hear that the first 8 chapters of The You You Are by Dr. Ricken Lazlo Hale, PhD are now available for free as both text and an audiobook read by Ricken himself: books.apple.com/us/book/the-...books.apple.comThe You You AreHealth, Mind & Body · 2025 2131
Paul Sample @paulsample.bsky.social · 27/01/2025Avoidance is better for mental health but not for decision making in an increasingly complex and unpredictable world. 050
Reposted by Paul SampleSung Kim @sungkim.bsky.social · 24/01/2025Aider reports that R1+Sonnet (R1 Thinking + Sonnet) set a new SOTA on the aider polyglot benchmark at 14X less cost compared to o1. 64% R1+Sonnet 62% o1 57% R1 52% Sonnet 48% DeepSeek V3 aider.chat/2025/01/24/r...aider.chatR1+Sonnet set SOTA on aider’s polyglot benchmarkR1+Sonnet has set a new SOTA on the aider polyglot benchmark. At 14X less cost compared to o1. 1419
Paul Sample @paulsample.bsky.social · 21/01/2025I tried a few biology-related queries and was impressed with the results. Researchers should check this out. 0110
Paul Sample @paulsample.bsky.social · 18/01/2025How have I been coding with Python for 10 years and just learned today that you can update the same line in a terminal using '\r' and end=''? print(f"\rDownload progress: {percent}%", end='') Thanks Claude. 0122
Reposted by Paul SampleEric Topol @erictopol.bsky.social · 16/01/202598% of microplastic particles (MP) in bottled water are smaller than 20 μm, which are much more likely to get thru the GI tract to blood and organ tissue. Municipal tap water was higher in MP than 8 of 10 bottled water brands journals.plos.org/water/articl... 1223474
Reposted by Paul SampleVikram Agarwal @vagar.bsky.social · 15/01/2025Super excited to announce our latest work. On a personal note, it's not an exaggeration to say that blood, sweat, and tears got us to the finish line on this: working w/ an outstanding global team of scientists in Germany, Japan, Russia, and USA responding in >100 pages of complex reviewer comments.nature.comMassively parallel characterization of transcriptional regulatory elements - NatureLentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements. 23610
Paul Sample @paulsample.bsky.social · 08/01/2025Not to brag but apparently I'm "on a roll!" over at LinkedIn. Blessed 🙏. 050
Reposted by Paul SampleJeremy Howard @howard.fm · 19/12/2024I'll get straight to the point. We trained 2 new models. Like BERT, but modern. ModernBERT. Not some hypey GenAI thing, but a proper workhorse model, for retrieval, classification, etc. Real practical stuff. It's much faster, more accurate, longer context, and more useful. 🧵 19620147
Reposted by Paul SampleDavid Bikard @dbikard.bsky.social · 13/12/2024Excited to share that we have just released genomenotebook 1.0 together with @trichomedoctor.bsky.social ! If you like to analyze genomics data in Jupyter notebooks this is for you. You can get beautiful genome browsers directly in your notebooks: dbikard.github.io/genomenotebo...dbikard.github.iogenomenotebookA genome browser in your Jupyter notebook 37722
Reposted by Paul SampleRom2 @yasbaltrine.bsky.social · 07/12/2024I made this free and open source dev tool: gitingest.com Replace "hub" with "ingest" in any github URL to get a text digest that you can feed into any LLM 167615
Paul Sample @paulsample.bsky.social · 05/12/2024Once again reminded of the amazing storytelling through data visualization that W.E.B Du Bois was doing in 1899! 040
Reposted by Paul SampleDiego del Alamo @delalamo.xyz · 04/12/2024New ESM models! Unlike ESM3 these seem to be classic sequence-only PLMs. The 300M and 600M param models are open source and available for commercial use, while the 6B param model is academic use only www.evolutionaryscale.ai/blog/esm-cam... 1204
Paul Sample @paulsample.bsky.social · 01/12/2024I'm really enjoying the structured output ability of Gemini for this zero shot classification problem. I'm trying to categorize bioRxiv papers to focus on the ones most relevant to my interests and it's working with very little fiddling. 1110
Reposted by Paul SampleAI x Bio Discovery @aixbiobot.bsky.social · 26/11/2024InterPLM: Discovering Interpretable Features in Protein Language Models via Sparse Autoencoders InterPLM uses sparse autoencoders (SAEs) to extract interpretable features from ESM-2 embeddings, revealing thousands of features linked to biological concepts, surpassing individual neuron ... (1/8) 102
Paul Sample @paulsample.bsky.social · 26/11/2024www.anthropic.com/news/model-c...anthropic.comIntroducing the Model Context ProtocolThe Model Context Protocol (MCP) is an open standard for connecting AI assistants to the systems where data lives, including content repositories, business tools, and development environments. Its aim... 010
Reposted by Paul SampleDaniel Vila @dvilasuero.hf.co · 25/11/2024Interested in open datasets for ML and AI? I've just created this feed with posts about @huggingface.bsky.social datasets! Don't miss the latest news and conversations about the secret sauce behind every AI model. bsky.app/profile/dvil... 34512
Paul Sample @paulsample.bsky.social · 20/11/2024Does anyone know of a good tool or model for extracting figures from academic papers? I'm hoping to pass in a PDF, get the bounding boxes for each figure, and then save them as images. 010
Reposted by Paul SampleJason Buenrostro @jbuenrostro.bsky.social · 16/11/2024Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay www.cell.com/cell-reports...cell.comDegradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assayTay et al. demonstrate an antigen-specific assay producing exhausted T cells that reflect those found in human tumors. They identify IKZF1 (IKAROS) as a driver of exhaustion progression and validate t... 24411
Reposted by Paul SamplePaul Krugman @pkrugman.bsky.social · 18/11/2024So will it all turn out OK once thermostatic public opinion turns around? Unfortunately, we have now put anti-democracy authoritarians in power, and there's a real possibility that this may have been our last more or less free election 4/ 1755779
Paul Sample @paulsample.bsky.social · 17/11/2024I will not reinstall WoW, I will not reinstall WoW…nytimes.com20 Years of Orcs, Guilds and Memes in World of WarcraftThe online role-playing game is more than just a game. It changed how we talk, love, grieve, spend money and hang out. 010
Reposted by Paul SampleGabriele Corso @gcorso.bsky.social · 17/11/2024Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread! 18610204
Paul Sample @paulsample.bsky.social · 16/11/2024It feels like we’re watching a hurricane, looming in the Gulf. Uncertain of the magnitude of the chaos that it will bring when it makes landfall on January 20th. 010
Reposted by Paul SampleSander Dieleman @sedielem.bsky.social · 15/11/2024In a gratuitous attempt to acquire more followers myself 😁, I've made a start on a "starter pack". Hopefully as more people from 🐦 make it over to 🦋, we can extend this a bit. Suggestions welcome! I've noticed not all accounts seem to be eligible to be added, anyone know what's up with that? 🤔 3412836
Reposted by Paul SampleKevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · 11/11/2024I tried to make a bioml starter pack. DM if you want me to add or remove you? go.bsky.app/2VWBcCd 298839
Paul Sample @paulsample.bsky.social · 14/11/2023This looks like a great resource for studying enhancers. www.biorxiv.org/content/10.1...biorxiv.orgAn encyclopedia of enhancer-gene regulatory interactions in the human genomebioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 010
Paul Sample @paulsample.bsky.social · 27/09/20233rd(?) ‘foundation model’ in the past 2 weeks predicting RNA biology from DNA sequence. www.biorxiv.org/content/10.1...biorxiv.orgAn RNA foundation model enables discovery of disease mechanisms and candidate therapeuticsbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 010
Reposted by Paul SampleChris Jackson @cajackson.org · 26/09/2023I dunno if bluesky paper threads are gonna work (I don't really understand why threads here aren't visible publicly), but I'm gonna try one anyway. Here's what I've been working on for the last year or two. 23818
Paul Sample @paulsample.bsky.social · 26/09/2023🧬🔄 www.biorxiv.org/content/10.1...biorxiv.orgCell type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed...bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 020
