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Hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels control neuronal firing thresholds. Together with sodium channels, they accumulate at sites of nerve injury, creating ectopic foci of...

Objectives To investigate the efficacy and safety of sodium channel blocker (SCB) rotation and/or combined use for neuropathic pain where the initial SCB is ineffective or poorly tolerated. Methods A...

Critics said I was attacking motorists. It’s more important for me that the city’s children are no longer breathing dangerous levels of pollution, says London mayor Sadiq Khan

A practical guide for individuals and organisations when the mobs gather

Commission an immediate public inquiry into how to ensure a responsible press given its contribution to Dr Arday’s tragic death.

Labour leader will visit king to accept role on Monday and will start making cabinet appointments that afternoon

This cohort study evaluates the effectiveness of the 2024-2025 COVID-19 vaccine against COVID-19–associated major adverse cardiovascular events.

Compassionate Gateshead is exploring how employers in Gateshead can be better supported to help employees returning to work after bereavement or during periods of (caring for someone with) a terminal ...

Health service bosses fear price inflation and unnecessary operations are costing the taxpayer. Now a fraud unit is getting involved

Palantir claims its software saves medics time they can spend on patient care, but an NHS leak shows the spy-tech firm’s products put doctors and nurses in the slow lane

Steve Reed, the local government secretary, says he will crack down on ‘unreasonable cost escalation’

Decision made to grant US tech firm ‘unlimited access’ to data in project to build integrated platform, according to reports * UK politics live – latest updates MPs have warned that an NHS decision to grant Palantir access to identifiable patient information in its plan to use AI to improve the health service is “dangerous” and will fuel public fears that data privacy is not being prioritised. NHS England has allowed staff from the US tech firm and other contractors access to patient data before it has been pseudonymised, despite internal fears of a “risk of loss of public confidence”, the Financial Times reported. Continue reading...

Background: High-quality evidence suggests that specialist palliative care reduces the odds of dying in hospital. The economic implications have not been establ...