Phosphate esters and anhydrides are central to biology, storing and transferring chemical energy to sustain processes from metabolism to translation. Among them, acyl phosphates are highly reactive, y...

In their Research Article (e202508481), Lenard Saile and Kun Dai et al. describe a feedback mechanism that controls non-equilibrium systems. Enantiomeric aminoacyl phosphates, depicted as left and ri...

What basic ingredients enable amino acid side-chain recognition and assembly without complex biological machinery? We show that even simple molecular sorters can organize amino acids in space and time...

In biological processes, peptide bonds are formed via reactive phosphate-containing intermediates, facilitated by compartmentalized environments. Here, the authors use aminoacyl phosphate esters that ...