Panos Roussos @panosroussos.bsky.social · 26/09/2026Thank you so much @martinowk.bsky.social! It’s been a tremendous team effort, made possible by the generosity of brain donors and their families. I’m looking forward to seeing these data widely used by the community! 110
Panos Roussos @panosroussos.bsky.social · 26/09/2026Thrilled to see the PsychAD package published! 🧠 Launched in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease. Supported by NIA. Deeply grateful to all donors and families. psych-ad.org www.nature.com/collections/...psych-ad.orgPsychADThe PsychAD Consortium builds population-scale, single-cell models of the human brain to uncover the molecular mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias, an... 174
Panos Roussos @panosroussos.bsky.social · 12/08/2026Excited to share our new work from #CDNeurogenomics at @sinaibrain.bsky.social @sinaigenetics.bsky.social #MountSinaiPsych, published in @natgenet.nature.com. We map human microglial states across aging and Alzheimer’s disease. Paper: nature.com/articles/s41... PDF: rdcu.be/fzdIrnature.comPlasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease - Nature GeneticsMolecular profiling of myeloid cells from the prefrontal cortex of 1,607 donors with varying degrees of Alzheimer’s disease neuropathology delineates distinct myeloid subtypes and identifies changes associated with aging and disease progression. 1133
Reposted by Panos RoussosNature @nature.com · 27/01/2026Nature research paper: Biological insights into schizophrenia from ancestrally diverse populations go.nature.com/4pMhb7fgo.nature.comBiological insights into schizophrenia from ancestrally diverse populations - NatureGenome-wide association studies incorporating data for populations of African ancestry provide an expanded view of the genetic basis of schizophrenia, which has previously been studied mainly in European and East Asian cohorts. 0207
Panos Roussos @panosroussos.bsky.social · 21/01/2026Now out in @nature.com: Biological insights into schizophrenia from ancestrally diverse populations. @sinaibrain.bsky.social @sinaigenetics.bsky.social cs.bsky.social @timbigdeli.bsky.social #CDNeurogenomics #MountSinaiPsych #MillionVeteranProgram and many collaborators Read: rdcu.be/eZ7herdcu.beBiological insights into schizophrenia from ancestrally diverse populationsNature - Genome-wide association studies incorporating data for populations of African ancestry provide an expanded view of the genetic basis of schizophrenia, which has previously been studied... 03313
Panos Roussos @panosroussos.bsky.social · 11/03/2025Congrats @jack-humphrey.bsky.social for isoMiGA now published in @naturegenet.bsky.social @sinaibrain.bsky.social ain.bsky.social @sinaigenetics.bsky.social s.bsky.social @trajnp.bsky.social np.bsky.social #CDNeurogenomics #MountSinaiPsych www.nature.com/articles/s41...nature.comLong-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature GeneticsThis isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and... 0113
Panos Roussos @panosroussos.bsky.social · 11/03/2025Big congrats to Tereza Clarence for “Multiomic single-cell profiling identifies critical regulators of postnatal brain” now published in @naturegenet.bsky.social @sinaibrain.bsky.social @sinaigenetics.bsky.social #CDNeurogenomics #MountSinaiPsych www.nature.com/articles/s41588-025-02083-8nature.comMultiomic single-cell profiling identifies critical regulators of postnatal brain - Nature GeneticsSimultaneous profiling of RNA and chromatin accessibility in single nuclei isolated from human postnatal brain regions from infancy to late adulthood identifies key cellular regulators and nominates t... 042
