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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 28/09/2026

Our paper is out in @natcomms.nature.com ! How does N1-methylpseudouridine (m1Ψ), the modification behind mRNA vaccines, cause +1 ribosome frameshifting, and how do we design around it? Open access: doi.org/10.1038/s414...

doi.org

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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 06/10/2025

cshperspectives.cshlp.org/content/earl... Review alert! In our latest review, we dissect the mechanistic structural and kinetic principles that govern -1 ribosome frameshifting and discuss how different flavours arise from distinct molecular pathways, yet converge on shared mechanistic features.

cshperspectives.cshlp.org

Mechanisms and Determinants of −1 Ribosome Frameshifting and Bypassing

A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences

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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 01/09/2025

sfb1565.uni-goettingen.de/symposion/ The 1st Symposium on Interconnections in Gene Expression by SFB1565 with an exciting list of speakers will feature our recent research on how the pivotal N1-methylpseudouridine modification in mRNA compromises translation fidelity! Don't miss it!

sfb1565.uni-goettingen.de

1st Symposion: Interconnections and Cross-Regulation of Gene Expression Processes – SFB1565

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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 27/03/2025

Well, I live for these moments! A mutation in tRNA-modifying enzyme confuses the ribosome to synthesize aberrant and, most importantly, immunogenic peptides that enhance immune response against tumors! Amazing data in many different layers; from cell biology to clinical research! Congratulations!

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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 16/02/2025

This is a promising study! Looking forward to the era that specific cancers could be prevented like infectious diseases. The more neoantigens we discover, the higher the variability of the vaccines!

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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 23/12/2024

It's the hook that matters 🪝 A great study by a good friend @eirinibellou.bsky.social and the pioneering @schuhlab.bsky.social !!! Amazing, truly intuitive images and invaluable insights with clinical perspectives! Congratulations!!!

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Reposted by Panos Poulis (currently in DE)

Schuh Lab @schuhlab.bsky.social · 23/12/2024

Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔 Our new study in @naturecomms.bsky.social reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9) www.nature.com/articles/s41...

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Reposted by Panos Poulis (currently in DE)

Ruben Gonzalez @rubenlgonzalez.bsky.social · 11/12/2024

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

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Panos Poulis (currently in DE) @panos-poulis.bsky.social · 05/12/2024

These aspects are often overlooked in research. Our effort to design cancer therapeutics should be as delicate and complicated, as cancer and the human body are.

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Reposted by Panos Poulis (currently in DE)

EMBL @embl.org · 04/12/2024

EMBL Group Leader @olivierduss.bsky.social and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie. Discover how they put snapshots in motion 👉 www.embl.org/news/science... #MolBiol 🧪 @natureportfolio.bsky.social

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Reposted by Panos Poulis (currently in DE)

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 29/11/2024

Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of... #LMBResearch

Model depicting the early steps during production of a membrane protein

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