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Layer-specific anatomical and physiological features of the retina’s neurovascular unit
Grimes et al. use EM to examine the ultrastructure of neurovascular units in mouse retina and discover differences in glial coverage, neuronal contacts, and susceptibility to disease. Glial calcium signals are activated by ATP and propagate through all layers. Neurovascular contacts near photoreceptors are compromised in retinitis pigmentosa.