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Owen Dando

@owendando.bsky.social
207 followers 153 following 1 posts

Bioinformatician at SIDB (sidb.org.uk) and UK DRI Edinburgh (ukdri.ac.uk). Academic website: lweasel.github.io (under construction).

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Reposted by Owen Dando
Bowles Lab @bowleslab.bsky.social · 05/07/2026
New pre-print from us! We compare two iPSC-microglia protocols, and take a look at the cell autonomous and non-cell autonomous effects of MAPT mutation: www.biorxiv.org/content/10.6...
biorxiv.org
Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT-S305N model of frontotemporal dementia.
Progressive and chronic neuroinflammation is associated with numerous neurodegenerative diseases, including primary tauopathies such as frontotemporal dementia and progressive supranuclear palsy. Unli...
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Reposted by Owen Dando
Axel Montagne @axelmontagne.bsky.social · 23/03/2026
🚨 New preprint 11,000+ human brain microvessels in cSVD. Key findings: • Early, bimodal pericyte loss • Endothelial activation comes later • Venous-like microvascular shift • Capillary density ↑ 💡 Suggests a sequential vascular pathology, not parallel. 🔗 www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Owen Dando
Bowles Lab @bowleslab.bsky.social · 01/12/2025
We are looking for a bioinformatics postdoc to join our group! Apply here 👇👇👇 www.jobs.ac.uk/job/DPQ109/p...
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Reposted by Owen Dando
Blanca Díaz Castro @bdiazcastro.bsky.social · 06/11/2025
Finally it’s here! 🌟⬇️ www.nature.com/articles/s41... I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer 1- How does the vasculature communicate with astrocytes? 2- Is this communication dependent to what happens in the body. 3- Is it relevant to human diseases?
nature.com
Fig. 1: Establishment of methods to identify astrocyte endfoot proteins. | Nature Communications
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Reposted by Owen Dando
Simons Initiative for the Developing Brain (SIDB) @sidb-edinburgh.bsky.social · 13/03/2025
SIDB and @ukdri.ac.uk researchers at The University of Edinburgh and @ncbsbangalore.bsky.social have found that FMRP maintains the form and function of neuron-maintenance cells, essential for rapid and efficient neuron communication. Read more: www.sidb.org.uk/news-events/...
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Reposted by Owen Dando
Lida Zoupi @lidazoupi.bsky.social · 11/02/2025
onlinelibrary.wiley.com/doi/full/10.... Hot off the press! We find changes in oligodendrocytes that lack FMRP! An excellent collaboration supported by @sidb-edinburgh.bsky.social .
onlinelibrary.wiley.com
The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes
Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP-deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in m...
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Reposted by Owen Dando
Simons Initiative for the Developing Brain (SIDB) @sidb-edinburgh.bsky.social · 28/11/2024
We are still recruiting for PhD studentships in basic & translational brain sciences! SIDB provides an annual stipend of £25K, plus tuition fees (inc. international). Find out more & apply by 26th Jan >> sidb.org.uk/phds/ #ExtraordinaryEdinburgh @edinunineuro.bsky.social
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Owen Dando @owendando.bsky.social · 19/11/2024
PhD opportunity – come and work with us on a PhD investigating immune-vascular interactions in human vascular dementia using snRNAseq analysis and spatial transcriptomics with Professor Karen Horsburgh, Dr Jill Fowler and Prof Raj Kalaria. www.findaphd.com/phds/project...
findaphd.com
Precision Medicine DTP - Defining vascular-immune cell heterogeneity and and intercellular communication in human vascular disease and dementia at University of Edinburgh on FindAPhD.com
PhD Project - Precision Medicine DTP - Defining vascular-immune cell heterogeneity and and intercellular communication in human vascular disease and dementia at University of Edinburgh, listed on Find...
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