iiinova — where your digital self keeps evolving

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British Society for Immunology @britsocimm.bsky.social · 30/09/2026

70 years of the BSI! We're so excited to bring the immunology community together in Glasgow to celebrate 🥳 Join us for #BSI26 from 30 Nov to 3 Dec, with 1,500+ delegates and 4 days of immunology research, clinical insights and networking. Early bird closes 21 October: vist.ly/5keek

BSI Congress 2026, SEC Glasgow, 30 November – 3 December. Celebrating 70 years. Early bird registration closing soon.

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 05/10/2026

📢 New open‑access study shows MAGE‑A4‑specific TCR‑NK cells combine innate NK killing with targeted TCR activity ,offering a potent, safe, “off‑the‑shelf” strategy for solid tumors. 🔗 vist.ly/5k2iy

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ZH-MA4-1a Cancer Treatment Diagram

Abstract. T cell (Tc) receptor (TCR)-based cell therapies have shown clinical efficacy across many cancer types and represent an attractive strategy for ta

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 05/10/2026

🧬 Open‑access study highlights ILC3 as key players in endometrial repair and regeneration, with distinct subsets active during menstruation and tissue rebuilding. Changes in ILC3 positioning in endometriosis may disrupt this process. 👉 vist.ly/5k2ic #Immunology #ILC3 #EndometrialHealth

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Dynamic roles of ILC3 in endometrial repair and regeneration

AbstractBackground. Innate lymphoid cells (ILCs) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-m

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 05/10/2026

📢 New open‑access study reveals that people with type 2 diabetes accumulate senescent‑like CD4+ EMRA T cells, driven by high glucose and mitochondrial dysfunction, helping explain weaker COVID‑19 vaccine responses in T2D. 🔗 vist.ly/5k2ja

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The generation of senescent-like CD4+ EMRA T cells in T2D and their contribution to poor COVID-19 vaccine responses

Abstract. CD4+ T cells are essential for protection from viral pathogens, such as SARS-CoV-2. However, an increase in the dysfunction CD4+ EMRA subset is l

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Reposted by Otto Balsiger

Clinical & Experimental Immunology @ceijournal.bsky.social · 02/10/2026

Could a high-fat diet help to protect against colitis in #Chron’sDisease? 🐁 High-fat diet inhibited the development of DSS-induced #colitis in mice, suggesting this diet influences gut barrier integrity and bacterial colonisation of the gut, reducing inflammation. 🔗 vist.ly/5kqzb

Nucleotide-binding oligomerization domain 2-independent colonization by Turicimonas muris induced by high-fat diet protects against dextran sodium sulfate-induced colitis

Diagram of NOD2 mice diets and Turicimonas muris colonization affecting colitis development.

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 02/10/2026

🧬 Open‑access research reveals that CASPASE‑8 supports αβ T‑cell survival through mechanisms independent of RIPK1‑mediated necroptosis, with key roles in CD8 T‑cell maintenance and NKT cell development. 👉 vist.ly/5kqxj #Immunology #TCells #CellDeath #OpenAccess

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Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells

AbstractIntroduction. CASPASE8 promotes both cell death and survival by acting as a trigger of apoptosis and a repressor of necroptosis. In T cells, the fu

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 02/10/2026

📢 New open‑access pediatric PID study published: fSCIG 10% maintains stable IgG levels in children aged 2–<16 years, with consistent pharmacokinetics across age groups and support for every‑3–4‑week dosing, helping reduce treatment burden without compromising efficacy. 🔗 vist.ly/5kqy3

Infographic on IGG trough levels in children with immunodeficiency.

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 01/10/2026

Today, on International Day of Older Persons, we're launching a new BSI and CARINA Network report on immune health and healthy ageing. It sets out recommendations to better integrate immune health into UK policy, research & healthcare. Read the report: vist.ly/5kjgv

Infographic showing immune health benefits in early life, adulthood, later life, and recovery.

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 01/10/2026

Learn bioinformatics wherever you are! Our self-paced courses let you learn at your own pace, with ongoing support from the Glasgow Bioinformatics Core, “This is probably the most useful course I have ever attended” Member discounts! Explore the courses: vist.ly/5kjwt

Promotional image for bioinformatics courses with colorful design and text on flexible self-paced learning.

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 30/09/2026

🧬 Open‑access study shows how spatial immune architecture and macrophage polarization shape immunotherapy responses in mismatch repair–deficient colorectal cancer, helping explain why metastatic lesions respond differently. 👉 vist.ly/5kesq #Immunotherapy

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Comprehensive spatial and immune profiling of metastatic mismatch repair–deficient colorectal cancer reveals response to immunotherapy

AbstractIntroduction. Mismatch repair-deficient (dMMR) colorectal cancers (CRCs) exhibit variable clinical responses to immune checkpoint inhibitors (ICIs)

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 30/09/2026

🧬 Open‑access study shows spermidine dampens dendritic cell activation via eIF5A hypusination and metabolic adaptation, reducing DC–T cell interactions and shaping immune regulation. 👉 vist.ly/5kesn #Immunology #DendriticCells #CellMetabolism #OpenAccess

Diagram showing reduced DC and T cell activation with eIF5a and spermidine.

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 28/09/2026

🔬 Open‑access research shows how different cytokines trigger distinct gene expression programs in human neutrophils, revealing their flexibility in shaping immune and inflammatory responses, far beyond frontline defence. 👉 vist.ly/5k59z #Immunology

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Reposted by Otto Balsiger

Clinical & Experimental Immunology @ceijournal.bsky.social · 01/10/2026

📣 We're going to be at #ESID2026! We're excited to hear the latest advances across primary immunodeficiencies, secondary immunodeficiencies or inborn errors of immunity research. If you're looking for a home for your research or would like to set up a meeting, get in touch!

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 25/09/2026

High‑throughput long‑read sequencing uncovers how chickens diversify their Ig genes: dominant somatic gene conversion, biased pseudogene usage, and focused CDR‑targeted insertions. A look into avian antibody evolution: bit.ly/45wSe95

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 28/09/2026

Can blood‑based T‑cell markers predict PD‑1 therapy response in melanoma? This study suggests yes, highlighting CD8⁺ proliferation in responders and CTLA‑4⁺ Tregs in non‑responders. Read here📄 bit.ly/4pw1rVL

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 25/09/2026

How Streptococcus pneumoniae interacts with innate immunity matters. New open‑access research shows neuraminidase A (NanA) shapes immune sensing and phagocytic clearance in microglia and macrophages, with implications for pneumococcal meningitis. vist.ly/5jtib

doi.org

Neuraminidase A controls pneumococcal recognition and fate: deficiency enhances immune sensing and intracellular survival, while treatment promotes phagocytic clearance.

Abstract. Streptococcus pneumoniae (pneumococcus) is a leading cause of bacterial meningitis worldwide and is associated with cerebrovascular complications

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 27/09/2026

How can vaccination during pregnancy protect a baby from RSV? Antibodies can cross the placenta, helping protect babies in their first months. New UKHSA data shows around 50% fewer infants under six months needed intensive care with RSV. Read our blog: vist.ly/5k3wq

Graphic with text about RSV and vaccine protection, featuring a shield.

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 24/09/2026

Just one week left to apply for the BSI Communication & Engagement Grant! Share your passion, improve public understanding & build trust in science through creative engagement projects. Up to £1,000 available. Submit by 1 October to inspire & educate: bit.ly/3Y9j8gm

BSI Communication and Engagement Grant, apply by Thursday 1 October.

Text promoting a BSI Communication & Engagement Grant applying by October 1.

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 22/09/2026

New research shows that adding CD28 signalling motifs to the CD3ζ chain boosts IL‑2 production and expansion of TCR‑engineered T cells, without reducing cytotoxicity. A promising step toward stronger TCR therapies for solid tumours. Read here: vist.ly/5jcu9 #Immunotherapy #TCells

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 23/09/2026

Measuring immune function in the wild is key to understanding resilience and disease. New open‑access research presents a practical immune toolkit for wild ungulates, revealing variation across individuals, populations and landscapes in bighorn sheep. vist.ly/5jhn6

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Out of the shed and into the field: an immune toolkit for measuring wild ungulate immune phenotypes at multiple scales

Here we demonstrate the utility of our field-tested “immune toolkit” in describing the immune phenotypic heterogeneity of bighorn sheep (Ovis Canadensis) a

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 23/09/2026

Open‑access review explores how targeting monocyte dynamics could offer new therapeutic approaches for multiple sclerosis, with insights from experimental models highlighting monocyte plasticity and inflammation resolution. vist.ly/5jhn9

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 22/09/2026

10 days to go until our next Foundations of immunology course takes place! We'll cover the basics of the immune system, including innate and adaptive immunity, health and disease, vaccines and immunotherapies. Book now and get a discount as a BSI member: vist.ly/5jdar

Promotional poster for British Society for Immunology course with an abstract cell image.

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 23/09/2026

Our December run of Omic data analysis and visualisation using R starts on Monday 7 December. Designed for wet-lab scientists with little/no bioinformatics experience, the course runs over 10 mornings (09:30–12:30 GMT). Book your place: vist.ly/5jhcw

Text promoting a bioinformatics training course in omic data analysis and visualization in R.

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 24/09/2026

We’re getting closer to #BSI26! Join 1,500+ immunologists in Glasgow from 30 November to 3 December for four days of science, discussion and networking, as we celebrate 70 years of the BSI. Early bird registration and late-breaking abstract submission close 21 October: vist.ly/5jnky

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 21/09/2026

What could an AI research assistant help you with? From finding literature to organising information and supporting your workflow, see some examples below 👇 📅 21 October - only one month to go until our first course! Book here: vist.ly/5j87b

Ad for building an AI research assistant course by British Society for Immunology.

Training course AI for immunologists table with challenges and solutions.

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 21/09/2026

🚀 Building on years of CAR‑T and TCR‑T innovation, this study showcases a sophisticated “all‑in‑one” engineered T‑cell approach for AML, combining antigen specificity, microenvironment responsiveness, bystander recruitment, and a safety switch in a single vector. Read more: vist.ly/5j9yx

Diagram of TCR signaling pathways with GM-CAR, CD3xCD33 BiTE, and tEGFR-cetuximab suicide switch.

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 21/09/2026

Wild mice show large, robust T‑cell receptor repertoires that stay broad across age and sex, while older mice develop more dominant clones, likely from lifelong pathogen exposure. A fascinating look at how immunity adapts in natural environments. vist.ly/5j8gx

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Reposted by Otto Balsiger

Discovery Immunology @discovimmunol.bsky.social · 18/09/2026

Research from Priscilla Y. L. Tng et al. shows how virulent ASFV strains disrupt the innate–adaptive immune axis in vivo, key insight for developing safer, more effective ASF vaccines. Read the article here: vist.ly/5ixap #CelebrateVaccines #Immunology #VaccinesWork

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Reposted by Otto Balsiger

Immunotherapy Advances @imtadvances.bsky.social · 18/09/2026

This study maps the spatial + immune landscape of metastatic dMMR colorectal cancer, revealing why some lesions respond to immunotherapy while others resist. Macrophage polarization and spatial immune architecture emerge as key drivers of outcome. 🔗 vist.ly/5ixaq

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Clinical & Experimental Immunology @ceijournal.bsky.social · 18/09/2026

📢 This open‑access study identifies PSMB8 as a biomarker predicting proton pump inhibitor response in paediatric eosinophilic esophagitis, supporting more personalized treatment decisions. 🔗 vist.ly/5ixam

Infographic on PSMB8 as a therapy response marker in eosinophilic esophagitis with study details.

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 17/09/2026

Completed our Omics data analysis and visualisation using R course & ready for the next challenge? Learn how to analyse single cell and spatial datasets with our advanced training course - starting Monday 12 October. 50% off for BSI members! Book here: vist.ly/5is56

Promotional banner for single cell and spatial omics course.

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British Society for Immunology @britsocimm.bsky.social · 17/09/2026

If you'd like to support the BSI by becoming a reviewer for our journals portfolio, you can sign up here: academic.oup.com/cei/pages/reviewer

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Reposted by Otto Balsiger

British Society for Immunology @britsocimm.bsky.social · 17/09/2026

It's #PeerReviewWeek and we want to recognise the valuable contributions of peer reviewers for their vital role in ensuring science can be shared in a timely way. Thank you to all who generously give their time and expertise to improve the quality of research published in our journals and beyond!

Thank you to our reviewers poster with immunology journal covers.

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Clinical & Experimental Immunology @ceijournal.bsky.social · 17/09/2026

Have you submitted to our new Immunometabolism Section yet? Led by Dr Lizzy Rosser (UCL), this is a dedicated home for cutting-edge research exploring how metabolism shapes immune function in health and disease. Learn more: vist.ly/58wxd #Immunometabolism #Immunology

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Reposted by Otto Balsiger

Clinical & Experimental Immunology @ceijournal.bsky.social · 02/09/2026

This review explores how long non-coding RNAs influence oral squamous cell carcinoma . The article brings together emerging evidence on the nerve–immune–cancer axis and highlights future directions for identifying new biomarkers and therapeutic targets. 📖 vist.ly/5gyuf #Immunology

doi.org

LncRNAs at the frontline of neuroimmune crosstalk in oral cancer

This review examines the current role of long non-coding RNAs (lncRNAs) in the neuroimmune crosstalk in oral squamous cell carcinoma and specifically their

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Clinical & Experimental Immunology @ceijournal.bsky.social · 03/09/2026

This open‑access study shows the β‑blocker nebivolol prevents T‑cell exhaustion and boosts cytotoxicity against breast cancer cells via β₂‑adrenergic receptor–dependent signalling, highlighting a potential new immunomodulatory strategy. vist.ly/5h4ta

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Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner

Prolonged TCR/CD3 and CD28 stimulation drives sustained NFATc1 signaling and TOX expression, resulting in increased inhibitory receptor expression and redu

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Clinical & Experimental Immunology @ceijournal.bsky.social · 07/09/2026

Join us in celebrating 60 years of pioneering clinical and translational immunology research! Explore our special collection showcasing the most-cited and widely-read articles that shaped our legacy: vist.ly/5hjvm #CEIat60

Three different covers of the Clinical and Experimental Immunology journal on a bookshelf.

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Clinical & Experimental Immunology @ceijournal.bsky.social · 15/09/2026

🧬 How does ageing with frailty reshape immune responses? This open‑access study links altered neutrophil signalling to impaired chemotaxis and increased ROS/NET production, highlighting key features of inflammageing. 👉 vist.ly/5ihau #ImmuneAgeing26

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Neutrophil Functional Analysis in Frailty and Health

In this study we have combined RNAseq with functional experiments to describe the phenotype of neutrophils from people with frailty. We found that frailty

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Immunotherapy Advances @imtadvances.bsky.social · 15/09/2026

Submissions are still open for our CD40 turns 40 Special Collection, exploring four decades of CD40 biology and its impact on immunotherapy across cancer, autoimmunity, and more 🧬 Learn more about submitting here: vist.ly/5ihwy #Immunology #Immunotherapy

academic.oup.com

Call for Papers

Immunotherapy Advances publishes scientifically rigorous open access research relating to manipulations of the immune system for the benefit of human and a

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Immunotherapy Advances @imtadvances.bsky.social · 15/09/2026

This review explores the bottom-up development of LGR5-targeting immunotherapeutics, showing how a highly specific α‑LGR5 antibody can be adapted into multiple modalities 📖 Read more: vist.ly/5ihju #Immunotherapy #CancerResearch #CARTcells #PrecisionMedicine #OpenAccess

Wnt pathway illustration with modulation by RSPO showing gene expression changes.

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British Society for Immunology @britsocimm.bsky.social · 14/09/2026

The tetanus vaccine was introduced into the UK’s routine infant immunisation programme in 1961. By the 1970s, tetanus in UK children under 15 had almost disappeared. Between 1985 and 2017, there were no cases in children under five. Read the story: vist.ly/5idxc

Infographic about tetanus vaccine impact with text and shield icon.

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British Society for Immunology @britsocimm.bsky.social · 15/09/2026

Heading to Glasgow for #BSI26? Early bird registration is open, with reduced rates available until 21 October 2026. Join 1,500+ immunologists: vist.ly/5igxk

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British Society for Immunology @britsocimm.bsky.social · 16/09/2026

Have you registered for the BSI West of Scotland Immunology Group showcase 2026? #WSIG26 Only 1 week left to book! Don’t miss out on a fantastic programme, inc Professor Anne O’Garra and a great line-up of speakers. 50% off for members. Sign up here: vist.ly/5imwe

Event details for BSI WSIG Showcase 2026 with Delphine Parrott memorial lecture beside a cathedral.

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British Society for Immunology @britsocimm.bsky.social · 01/09/2026

Registration is open for Incorporating AI into your analysis workflows #AIForBiosciences Join us online 9 February 2027 for practical AI and omics training. Some R experience recommended, but all code is provided. 🎓 BSI member discount available! 🔗 vist.ly/5gtmi

Training course on AI for analysis workflows with geometric design.

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