iiinova — where your digital self keeps evolving

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The EMT community still cannot face EMT's essential flaws directly They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

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There are no EMT factors. They are just embryonic neural proteins. If there are only mesenchymal but no neural proteins, there would have been no animals at all, then no cancer, no cancer research, no cancer papers, no....

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Ying Cao @neuralgrndstate.bsky.social · 29/08/2026

Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

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Very very tiny/preliminary research with the last few bucks, but might be somewhat inspiring-[Preprint] ‘Expression of immune checkpoint VISTA represents a differentiated state of cancer cells and plays a role in regulating actin cytoskeleton’ biorxiv.org/content/10.6...

biorxiv.org

Expression of immune checkpoint VISTA represents a differentiated state of cancer cells and plays a role in regulating actin cytoskeleton

Immune checkpoint blockade has revolutionized cancer therapy, but the therapeutic efficacy is limited. Clinical trials on blockade of newly identified immune checkpoints didn't show promising result, ...

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Ying Cao @neuralgrndstate.bsky.social · 29/08/2026

Questions🤔🤨 A gene with high expression in tumor cells&correlating with progression/poor prognosis seems to be a good candidate of target, right? Better to target malignant or nonmalignant, high or weak malignant cells in tumors? Immune checkpoints also play other roles than immunity?

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Cancer the disease of living cells, cannot be understood only by mol. symbol analysis.

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If neural genes are always interpreted as mesenchymal stuff, what could have happened? If no neural genes, then no animals, then no cancer, no EMT, no cancer research, no cancer papers, ...

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Neural stemness as the core property of cancer cell: predetermined by evolution

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Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates frontiersin.org/journals/cel...

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Cancer is a systemic disease. Understanding a systemic disease needs the understanding of systemic rules. Or cancer is the manifestation of the power of the general rules dictating the animal kingdom, which are predetermined by evolution. Development&cancer&cancer plasticity..👇

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Lack of basic rationale in epithelial-mesenchymal transition and its related concepts - Cell & Bioscience

link.springer.com

Epithelial–mesenchymal transition (EMT) is defined as a cellular process during which epithelial cells acquire mesenchymal phenotypes and behavior following the downregulation of epithelial features. ...

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Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many are expecting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

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Ying Cao @neuralgrndstate.bsky.social · 20/08/2026

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Ying Cao @neuralgrndstate.bsky.social · 20/08/2026

Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

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Ying Cao @neuralgrndstate.bsky.social · 20/08/2026

There's been great adrenaline-pumping breakthrough news these days about AI treating or even curing cancer. But I wonder if AI could help with a specific question that is much simpler than curing cancer. What the hell is so-called EMT? nature.com/articles/s41... sciencedirect.com/science/arti...

sciencedirect.com

Association between green tea-based chemoprevention and epithelial–mesenchymal transition: current understanding and future perspectives

Premalignant lesions provide a crucial window of opportunity for cancer chemoprevention. Green tea, particularly its major catechin, epigallocatechin-…

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Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates frontiersin.org/journals/cel...

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'...therapeutically exploit EMT-associated vulnerabilities' EMT/P is seriously claimed to be a target of cancer therapy, but no one can tell what it is, related studies are still mainstream of cancer res., patients perhaps are awaiting EMT-based therapies,... Sigh.

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Those who believe that EMT/P is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT/P&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

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EMT/EMP is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps poor patients are awaiting that), &keep instilling 'EMT/P knowledge' in young researchers. Sigh.

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You don't know what are the epithelial/mesenchymal states, specific E/M markers... &You have forgotten cancer cells are the first cells proven to be pluripotent But you know EMT/EMP&they can explain cancer cell plasticity&everything of cancer @cp-trendscancer.bsky.social

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Understanding 'Neuron–tumor communication in solid tumors' through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates www.frontiersin.org/journals/cel... @cp-trendscancer.bsky.social

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