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Ying Cao @neuralgrndstate.bsky.social · 28/09/2026

As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stem cells, incl. LRP8&the so-called EMT genes. They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. frontiersin.org/journals/cel...

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Ying Cao @neuralgrndstate.bsky.social · 28/09/2026

Truly beautiful and important work.👏🫡 But anybody knows what is the magical epithelial-mesenchymal transition stuff? Nobody knows. It doesn't matter at all. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

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Ying Cao @neuralgrndstate.bsky.social · 26/09/2026

Those who believe that EMT is helpful for understanding cancer&other things should first figure out what the hell is the so-called EMT 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1... www.cell.com/cell/fulltex...

cell.com

Shifts in embryonic oxygen levels cue heterochrony in limb initiation

Mammalian embryos see a substantial increase in available oxygen once the placenta forms. This increase in oxygen exposure serves as a trigger for initiating the development of the hindlimb, thus cont...

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Ying Cao @neuralgrndstate.bsky.social · 20/09/2026

Understanding cancer cell/metastasis/complexity/therapy/resistance/inverse correlation between cancer&Alzheimer's/cancer pain/... as a whole by understanding neural stemness as the core property of cancer cell &the rules it dictates. frontiersin.org/journals/cel... @natrevcancer.nature.com

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Ying Cao @neuralgrndstate.bsky.social · 20/09/2026

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Ying Cao @neuralgrndstate.bsky.social · 13/09/2026

Understanding cancer cell/complexity/therapy/CANCER PAIN &even the inverse correlation between cancer and Alzheimer's &... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. frontiersin.org/journals/cel...

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Ying Cao @neuralgrndstate.bsky.social · 13/09/2026

Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates @natrevcancer.nature.com frontiersin.org/journals/cel...

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Ying Cao @neuralgrndstate.bsky.social · 05/09/2026

@ruxandrabio.bsky.social @nytopinion.nytimes.com How was this beautiful conclusion reached? 'science is no longer the main bottleneck to new drugs' How much cancer cells and cancer have been properly understood?

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Ying Cao @neuralgrndstate.bsky.social · 29/08/2026

Very very tiny/preliminary research with the last few bucks, but might be somewhat inspiring-[Preprint] ‘Expression of immune checkpoint VISTA represents a differentiated state of cancer cells and plays a role in regulating actin cytoskeleton’ biorxiv.org/content/10.6...

biorxiv.org

Expression of immune checkpoint VISTA represents a differentiated state of cancer cells and plays a role in regulating actin cytoskeleton

Immune checkpoint blockade has revolutionized cancer therapy, but the therapeutic efficacy is limited. Clinical trials on blockade of newly identified immune checkpoints didn't show promising result, ...

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Ying Cao @neuralgrndstate.bsky.social · 29/08/2026

Questions🤔🤨 A gene with high expression in tumor cells&correlating with progression/poor prognosis seems to be a good candidate of target, right? Better to target malignant or nonmalignant, high or weak malignant cells in tumors? Immune checkpoints also play other roles than immunity?

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Ying Cao @neuralgrndstate.bsky.social · 20/08/2026

The EMT community still cannot face EMT's essential flaws directly They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

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Ying Cao @neuralgrndstate.bsky.social · 20/08/2026

Epithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh.

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Ying Cao @neuralgrndstate.bsky.social · 20/08/2026

There's been great adrenaline-pumping breakthrough news these days about AI treating or even curing cancer. But I wonder if AI could help with a specific question that is much simpler than curing cancer. What the hell is so-called EMT? nature.com/articles/s41... sciencedirect.com/science/arti...

sciencedirect.com

Association between green tea-based chemoprevention and epithelial–mesenchymal transition: current understanding and future perspectives

Premalignant lesions provide a crucial window of opportunity for cancer chemoprevention. Green tea, particularly its major catechin, epigallocatechin-…

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Ying Cao @neuralgrndstate.bsky.social · 16/08/2026

You don't know what are the epithelial/mesenchymal states, specific E/M markers... &You have forgotten cancer cells are the first cells proven to be pluripotent But you know EMT/EMP&they can explain cancer cell plasticity&everything of cancer @cp-trendscancer.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 16/08/2026

Understanding 'Neuron–tumor communication in solid tumors' through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates www.frontiersin.org/journals/cel... @cp-trendscancer.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 16/08/2026

"Neural ckeckpoint" @cp-trendscancer.bsky.social Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates www.frontiersin.org/journals/cel... Cancer cells are characteristic of neural cells

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Ying Cao @neuralgrndstate.bsky.social · 13/08/2026

Resistance is an integral part of cancer cell property: neural stemness, and its reg. net. Without effective suppression of neural stemness, resistance is always there. There are ways to reprogram the whole reg. net, instead of single or combi. of single molecules, cancer cell: via differentiation

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Ying Cao @neuralgrndstate.bsky.social · 13/08/2026

As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stem cells, incl. KRAS/AKT/MYC/ERK... They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. frontiersin.org/journals/cel...

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Ying Cao @neuralgrndstate.bsky.social · 11/08/2026

Pure data analysis generates revolutionary conclusion🤔🫡. pnas.org/doi/10.1073/... ashpublications.org/blood/articl... @pnas.org @bloodjournal.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 11/08/2026

The evolutionary&developmental origin of 'plasticity'👇 @cp-cellstemcell.bsky.social 'Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates' frontiersin.org/journals/cel...

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Ying Cao @neuralgrndstate.bsky.social · 11/08/2026

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Ying Cao @neuralgrndstate.bsky.social · 11/08/2026

Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

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Ying Cao @neuralgrndstate.bsky.social · 11/08/2026

EMT is absolutely a magical stuff Nobody knows what it is but people say it explains cancer&other things, &can be exploited to develop cancer therapy (perhaps many are awaiting that) &keep instilling 'EMT knowledge' to young researchers Sigh www.nature.com/articles/s41... @natcomms.nature.com

nature.com

Single cell multiomics unravel the transcription networks controlling the different EMT tumor states - Nature Communications

Epithelial-to-mesenchymal transition (EMT) involves cancer cells shifting between different states linked to tumor progression. Here, the authors use single-cell multiomics and CRISPR/Cas9-mediated lo...

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Ying Cao @neuralgrndstate.bsky.social · 06/08/2026

If this still isn't the true face of cancer, then maybe another 6M papers need to be published to uncover it, or we'll just have to turn to artificial intelligence.

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Ying Cao @neuralgrndstate.bsky.social · 03/08/2026

Plus, you don't know what the hell is EMT, but you know clearly EMT is responsible for resistance. LOL. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.1...

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Ying Cao @neuralgrndstate.bsky.social · 03/08/2026

Like that cancer cells are not solely a problem of single molecules, resistance is not, either The core property of cancer cell is neural stemness. Without fully inhibition of neural stemness of cancer cells, resistance is always there www.nature.com/articles/s41...

nature.com

Cancer drug response and resistance: molecular mechanisms and combating strategies - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Cancer drug response and resistance: molecular mechanisms and combating strategies

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Ying Cao @neuralgrndstate.bsky.social · 31/07/2026

NO ONE HAS EVER MENTIONED THAT CANCER CELLS THEMSELVES ARE CHARACTERISTIC OF NEURAL CELLS. Or maybe this doesn't deserve to be mentioned at all 1. Cancer (tumorigenic) cells≈Neural stem/progenitor cells 2. Tumors ≈ Conjoined twin-like structures (formed during postnatal stage)

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Ying Cao @neuralgrndstate.bsky.social · 31/07/2026

Basic logic: The central part, ie. the most important part, of cancer is cancer cells; The core property of cancer cells is neural stemness; Cancer cells can differentiate into neuronal (&nonneural) cells cuz they are pluripotent)&thus connect host nerve www.science.org/doi/10.1126/...

science.org

Targeting neurotumoral signaling networks in cancer

Cancers hijack the nervous system to fuel growth and evade targeting; decoding this interface opens avenues for patient care.

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Ying Cao @neuralgrndstate.bsky.social · 28/07/2026

'..reporter enriches .. in the OCT4hi SOX2hi ..use the umbrella term CSC...' Like most cancer promoting genes, Oct4/Sox2/Yap..are embryonic neural ∴cancer stem cells≈neural stem/progenitor cells I guess you know what Oct4/Sox2 mean if you don't know Yap/Taz.. @natcellbio.nature.com

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Ying Cao @neuralgrndstate.bsky.social · 28/07/2026

..reporter enriches both .. in the OCT4hi SOX2hi ..use the umbrella term CSC...' Like most cancer promoting genes, Oct4/Sox2/Yap..are embryonic neural. ∴cancer (tumorigenic) cells≈neural stem/progenitor cells Cancer stemness=neural stemness This is crucial @natcellbio.nature.com

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Ying Cao @neuralgrndstate.bsky.social · 26/07/2026

Cancer cells are characteristic of neural cells. How can you conclude that NTN1, a well known neural factor, is only expressed by CAFs but not by cancer cells themselves? @cp-cancercell.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 26/07/2026

Studies like this focus on effect of host nerve on tumors routinely explained by transduction from neural factors of the nerve either directly/via other cells to other neural factors expressed by cancer cell But you guys never mentioned the neural feature of cancer cell @cp-cancercell.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 26/07/2026

The EMT community still cannot face EMT's essential flaws They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs link.springer.com/article/10.1...

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Ying Cao @neuralgrndstate.bsky.social · 26/07/2026

This study circumlocutiously illustrates the promoting effect of host nerves on cancer, &even shows involvement of the magical undefinable EMT stuff in this process, but without mentioning anything about neural cell feature of cancer cells. LOL @cp-cancercell.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 25/07/2026

hallmarks of cancer now also complicated. what is the 'central tenet'? NEURAL STEMNESS: the core property of cancer cells. It unifies cancer cell phenotypic traits how to co-target multiple capabilities? targeting neural stemness via differentiation @cp-trendscancer.bsky.social

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Ying Cao @neuralgrndstate.bsky.social · 25/07/2026

“The latest iteration of the hallmarks-of-cancer framework has converged on a central tenet, that is, durable tumor control requires the co-targeting of multiple oncogenic capabilities rather than single-pathway inhibition” @cp-trendscancer.bsky.social www.cell.com/trends/cance...

cell.com

Beyond one gene, one target: Next-generation precision oncology

The Drug Rediscovery Protocol by K. Verkerk, et al., operationalized nationwide biomarker-guided, off-label precision oncology. Yet outcomes (15.7% response rate) mirror a decade of studies, indicatin...

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Ying Cao @neuralgrndstate.bsky.social · 20/07/2026

LOL. You have forgotten that cancer cell is pluripotent You don't know what the hell is the so-called EMT You cannot tell what cancer stem cells/cancer stemness exactly mean But you know how to understand tumor heterogeneity nature.com/articles/s41... nature.com/articles/s41...

nature.com

Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets

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Ying Cao @neuralgrndstate.bsky.social · 20/07/2026

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