Reposted by Neda Barghi
Why is epistasis so common in crosses, yet rare in GWAS? Maybe we’re looking for the wrong thing.
(contd.)
doi.org/10.1093/gene...
doi.org
Epistatic redundancy reconciles pervasive genetic interactions with their rarity in genome-wide analyses
Abstract. Epistasis, the genetic interaction between loci, has long been recognized as a fundamental feature of the genetic architecture, but its importanc