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Nature Reviews Endocrinology @natrevendo.nature.com · 13/10/2026

In this Consensus Statement, an international group of experts provide updated recommendations on the treatment of acromegaly, including discussion of treatment outcomes go.nature.com/3Wn4DKd #MedSky #EndoSky

Figure showing a proposed updated algorithm for medical treatment in patients with acromegaly that is inadequately controlled after pituitary surgery.

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Nature Reviews Endocrinology @natrevendo.nature.com · 13/10/2026

Here, Rodrigo Fernández-Verdejo, Eric Ravussin & Jose E. Galgani discuss models of body weight regulation and consider possible experimental scenarios to test which model is valid (£) go.nature.com/4iikIJN #MedSky #EndoSky

Figure showing models of homeostatic regulation.

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Nature Reviews Endocrinology @natrevendo.nature.com · 13/10/2026

In this Review, Andrew Chan and colleagues synthesize evidence regarding the association of obesity and type 2 diabetes with early-onset colorectal cancer (£) go.nature.com/4hI8KsK #MedSky #EndoSky

Figure showing a schematic representation of potential mechanisms linking obesity and T2DM to early-onset colorectal cancer.

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Nature Reviews Endocrinology @natrevendo.nature.com · 13/10/2026

This Review from Carlos A. Monteiro and colleagues assesses the role of ultra-processed foods in obesity, examining the epidemiological evidence, biological mechanisms and implications for policymakers (£) bit.ly/47gbZla #MedSky #EndoSky

Figure showing physiological pathways underlying the association between ultra-processed dietary patterns and obesity.

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

From our November issue: A Journal Club from Linus L. H. Chang discusses a paper looking at how a high-fat diet promotes tumour formation in the epithelium of mice (£) go.nature.com/4jjeydw #EndoSky #MedSky

White text against a blue background reads: "...both chronic inflammation and alterations in lipid metabolism contribute separately to the suppression of apical extrusion"

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

In our November issue, a Journal Club from Jose Carlos de Lima-Junior explores a paper on the function of UCP1 (£) go.nature.com/4jj9xSe #EndoSky #MedSky

White text against a blue background reads: "The study by Fedorenko et al. remains a landmark in membrane biophysics and metabolic biology"

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

From our November issue: Elisabeth F. C. van Rossum et al introduce CheckCausesObesity.com and outline how it can be used to support patient care and advance research rdcu.be/73P1hbND3z7a #EndoSky #MedSky

White text against a blue background reads: "CCO supports individualized assessment, treatment and population-level monitoring"

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

In our November issue, Jelena Kolic, Noor Assaf & James D. Johnson explore the regulation of insulin secretion, including the effects of various nutrient and non-nutrient factors (£) go.nature.com/4yg0KEa #EndoSky #MedSky

Figure showing nutrient and non-nutrient regulation of insulin secretion.

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

In our latest issue: Stephen Simpson et al outline the complexity of macronutrient mixtures, and discuss their role in energy intake, systemic physiology, body composition and health across the life course (£) go.nature.com/4B8l7pQ #EndoSky #MedSky

Figure showing Key principles of the Nutritional Geometry Framework.

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

From our November issue: Dimitra Micha & colleagues cover the role of collagen type I haploinsufficiency in the pathogenesis of osteogenesis imperfecta type 1 (£) bit.ly/3VJgGRY #MedSky #EndoSky

Figure showing bone pathophysiology in osteogenesis imperfecta type 1 and clinical trial interventions.

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

Featured in our November issue: Hinds et al explore the contribution of the hepatic sympathetic and parasympathetic nervous systems in the development of MASLD and its progression to MASH and hepatocellular carcinoma rdcu.be/YoaKpLXQjS4a #MedSky #EndoSky

Figure showing hepatic nerve degeneration across the stages of steatosis.

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/10/2026

The November issue of @natrevendo.nature.com is now online! Check it out for articles on MASLD, osteogenesis imperfecta, macronutrients, insulin secretion & more -> www.nature.com/nrendo/

Front cover of Nature Reviews Endocrinology, featuring a stylised representation of hepatocytes, overlayed with neurons.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026

Here, this international Consensus Statement by Maria Fleseriu et al provides guidelines on the management of pituitary incidentalomas go.nature.com/4itSjB3 #EndoSky #MedSky

Figure showing an algorithm for assessment of an incidentally discovered pituitary adenoma on imaging managed conservatively.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026

In this article, Qiong A. Wang and colleagues outline the in endocrine and metabolic function that occur in various adipose tissue depots during ageing (£) go.nature.com/4gSSbdl #EndoSky #MedSky

Figure showing cellular alterations in WAT during the early stage of ageing.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026

Here, Francisca L. Henriques, Irina Buckle & Josephine M. Forbes review strategies for type 1 diabetes mellitus prevention (£) go.nature.com/4gT9Stf #EndoSky #MedSky

Figure showing a selection of therapeutic approaches in phase Ib–III clinical trials aiming to prevent ongoing β-cell damage and destruction during the development and progression of T1DM.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/09/2026

In this Review, Anne-Simone Parent et al discuss the potential effects of endocrine-disrupting chemicals in female reproductive health (£) bit.ly/4r8Lx5U #EndoSky #MedSky

Figure showing female reproductive development and functions susceptible to perturbation by endocrine-disrupting chemicals.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

From our latest issue - a Journal Club from Fadi Khalaf looking at how local catecholamine catabolism blunts lipolysis in ageing adipose tissue (£) go.nature.com/4cyylRX

Against a blue background, white text reads "This was a landmark observation because it reframed adipose tissue ageing as a problem of neural–immune–metabolic communication."

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

In our October issue, Chuang Liu and colleagues present a Comment on mRNA-LNP therapeutics for obesity (£) go.nature.com/4h1syFT #EndoSky #MedSky

Figure showing mRNA-LNPs for application in obesity treatment.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

From our October issue: Leonardo de Assis et al discuss the transition from postdoctoral researcher to independent investigator rdcu.be/pggtNCksJtHa #EndoSky #MedSky

Screenshot of a text box titled 'Insights from the DDEA Postdoc Summit 2025'.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

In this Perspective, Soo Lim et al advocate for an approach to assessments for obesity in Asian populations that takes ethnicity-specific factors into account (£) go.nature.com/4dr6NhA #EndoSky #MedSky

Figure showing the clinical features of Asian people with obesity.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

In our latest issue: Christofer Juhlin and colleagues discuss how molecular alterations in thyroid cancer affect iodine uptake and describe redifferentiation strategies that aim to improve the effectiveness of radioiodine administration (£) go.nature.com/4qZ1Ty2 #EndoSky #MedSky

Figure showing an overview of thyroid hormonogenesis.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

In our latest issue: Tony Lam and colleagues outline how lipid sensing triggers hormonal and neural mechanisms that regulate satiety and glucose homeostasis and how these pathways are affected by obesity and metabolic disease (£) go.nature.com/4yte0WF #EndoSky #MedSky

Figure showing mechanisms of small intestinal lipid sensing in glucose regulation.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

From our October issue: Tadataka Tsuji & Yu-Hua Tseng discuss the adipose humoral and neuronal pathways that operate through inter-organ communication to regulate systemic metabolism rdcu.be/pCN8xZHMZuua #EndoSky #MedSky

Figure showing integration of humoral and neuronal pathways linking adipose tissue to systemic metabolism.

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Nature Reviews Endocrinology @natrevendo.nature.com · 09/09/2026

The @natrevendo.nature.com October issue is now online! Featuring articles on adipose tissue, lipid sensing, thyroid cancer, clinical obesity and more -> www.nature.com/nrendo/ #EndSky #MedSky

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/08/2026

In this Review, Sophie Monnerat and colleagues discuss the causes and treatment of hyponatraemia in older people (£) go.nature.com/4zfIUms #MedSky #EndoSky

Schematic showing factors that contribute to syndrome of inappropriate antidiuresis (SIAD).

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/08/2026

Here, Maria Lytrivi and colleagues discuss how endoplasmic reticulum stress affects pancreatic β cells (£) go.nature.com/4xCx0lg #MedSky #EndoSky

On the left is an image of a pregnant person and a baby, with zoom-ins highlighting the pancreas and pancreatic islet cells. A lightning bolt pointing to the group of cells represents a source of endoplasmic reticulum stress. On the right is a schematic showing that this stress can prevent β-cell numbers from increasing as they should during embryonic and neonatal development.

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Nature Reviews Endocrinology @natrevendo.nature.com · 12/08/2026

Here, Hector Ortega et al review the utility and limitations of different types of polygenic risk scores used to classify and screen for diabetes mellitus (£) go.nature.com/3TJpA0W #MedSky #EndoSky

An image showing a group of people on the left, representing people without diabetes mellitus, with type 1 diabetes mellitus or with type 2 diabetes mellitus. The centre and right show graph-like schematics illustrating that polygenic risk scores for diabetes mellitus tend to be more different when comparing people with type 1 diabetes mellitus to a control population than when comparing people with type 2 diabetes mellitus to a control population.

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

In our September issue, Sushant Saluja et al discuss the challenges and advantages of using precision medicine in low-income and middle-income countries and in small island developing states (£) go.nature.com/3TSryvV #MedSky #EndoSky

A schematic showing different challenges of implementing precision medicine in small island developing states and low-income and middle-income countries, as well as opportunities to facilitate precision medicine in these contexts.

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

In our latest issue, Gian Paolo Rossi and colleagues discuss the use of aldosterone synthase inhibitors as treatments for cardiovascular disease (£) go.nature.com/4zckxWQ #MedSky #EndoSky

A schematic showing how levels of aldosterone that are too high can affect the heart, vasculature and kidneys and contribute to cardiorenal disease.

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

In our September issue, Antonio Ceriello and colleagues discuss the causes and effects of discontinuing GLP1RAs and tirzepatide (£) go.nature.com/4bGGJyl #MedSky #EndoSky

A schematic showing how treatment with GLP1RAs can induce vasodilation and reduce inflammation.

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

Here, Helena J. Teede et al. discuss the pathophysiology of polyendocrine metabolic ovarian syndrome (formerly known as polycystic ovary syndrome) and its effects on pregnancy (£) rdcu.be/fzgWC #MedSky #EndoSky

An outline of a body showing selected organs and tissues, with zoom-ins and labels showing how they are dysregulated in polyendocrine metabolic ovarian syndrome (formerly known as polycystic ovary syndrome).

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

From our September issue: This Comment article by Ruiz et al. discusses the importance of complementing obesity pharmacotherapy with exercise (£) go.nature.com/4gqwGjz #MedSky #EndoSky

A graph-like schematic showing how resistance training and aerobic exercise before and while taking weight loss drugs can improve muscle mass, reduce adipose tissue mass and promote overall weight loss.

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

In our September issue, Gaofei Wei et al. comment on reframing cancer cachexia as a treatable disease (£) rdcu.be/fzgbS #MedSky #EndoSky

An image of a human body showing certain organs, with labels showing the effects of cancer cachexia.

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Nature Reviews Endocrinology @natrevendo.nature.com · 11/08/2026

The @natrevendo.nature.com September issue is now online! Featuring Reviews on PMOS in pregnancy, aldosterone synthase inhibitors as treatments for cardiovascular disease and causes and effects of discontinuing GLP1RAs or tirzepatide -> www.nature.com/nrendo/ #EndoSky #MedSky

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Nature Reviews Endocrinology @natrevendo.nature.com · 20/07/2026

In this Review, Andrzej Slominski and colleagues discusses the role of the skin as a neuro–immuno–endocrine organ and its influence on whole-body homeostasis and allostasis (£) go.nature.com/45cupC9 #EndoSky #MedSky

Figure showing skin homeostasis and allostasis are regulated by the local neuro–immuno–endocrine system in response to environmental factors.

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Nature Reviews Endocrinology @natrevendo.nature.com · 20/07/2026

Here, Garth Cooper et al review the physiological roles of amylin and the current progress of amylin mimetic therapeutics (£) go.nature.com/4wWq2qU #EndoSky #MedSky

Figure showing the physiological effects of amylin.

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Nature Reviews Endocrinology @natrevendo.nature.com · 20/07/2026

In this Review, Gary Hammer et al outline the mechanisms that regulate the establishment and maintenance of the adrenal stem cell niche (£) bit.ly/4foEZut #EndoSky #MedSky

Figure showing therapies targeting adrenal stem and progenitor cells to treat monogenic diseases.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

In our August issue, Outi Mäkitie and colleagues review the pathogenesis and intersecting mechanisms of monogenic bone mass disorders (£) go.nature.com/4feQHYO #EndoSky #MedSky

Figure showing molecular mechanisms in cells of the haematopoietic lineage causal for osteoclast-poor or osteoclast-rich high bone mass.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

From our latest issue: Sobha Sivaprasad & Stela Vujosevic discuss advances in imaging and treatment that are improving outcomes for patients with diabetic retinopathy (£) go.nature.com/4fggOOS #EndoSky #MedSky

Screenshot of a text box with five bullet points about key messages of a Review.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

In our August issue: Mírian Romitti & Sabine Costagliola describe how the development of various thyroid organoid models has advanced research into thyroid development, dysregulation and disease (£) go.nature.com/4wIJ6IZ #EndoSky #MedSky

Figure showing a schematic representation of thyroid developmental stages.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

In our latest issue, Didier Hober and colleagues briefly discuss how Epstein–Barr virus might protect against type 1 diabetes mellitus (£) go.nature.com/4gI8udj #EndoSky #MedSky

Figure showing the potential connections between EBV and T1DM.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

From our August issue: in a Comment article, Andreas L. Birkenfeld & Mathias Heikenwälder discuss cancer prevention through metabolic remission (£) bit.ly/4w1pDmJ #EndoSky #MedSky

Screenshot of a text box titled 'Prediabetes and remission'.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

Featured in our August issue: Julien Paccou et al discuss the aetiology, pathogenesis, diagnosis and management of secondary osteoporosis rdcu.be/ftLfa #EndoSky #MedSky

Figure showing a diagnostic flow chart for secondary osteoporosis.

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Nature Reviews Endocrinology @natrevendo.nature.com · 14/07/2026

The @natrevendo.nature.com August issue is now online! This month, read about secondary osteoporosis, human thyroid organoids, diabetic retinopathy, monogenic bone mass disorders & more -> www.nature.com/nrendo/ #EndoSky #MedSky

Front cover of Nature Reviews Endocrinology's August 2026 issue.

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Nature Reviews Endocrinology @natrevendo.nature.com · 19/06/2026

This Perspective discusses standard and novel therapies for individualized care of transgender and nonbinary youth as well as the ethical principles guiding the provision of innovative therapies in gender-affirming medical interventions (£) go.nature.com/44j65Ov #EndoSky #MedSky

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Nature Reviews Endocrinology @natrevendo.nature.com · 19/06/2026

Here, Anyongqi Wang & John Roger Speakman summarize evidence regarding potential adverse effects of calorie restriction and highlights the complexity of extrapolating findings from animal studies to humans (£) go.nature.com/43MLv95 #EndoSky #MedSky

Schematic diagram summarizing the effects of calorie restriction on bone health.

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Nature Reviews Endocrinology @natrevendo.nature.com · 19/06/2026

In this Review, Domenico Accili et al outline the mechanistic relationship between hyperinsulinaemia and insulin resistance in type 2 diabetes mellitus (£) go.nature.com/4vlLNQv #EndoSky #MedSky

Figure showing how hyperinsulinaemia uncouples insulin action on different biological responses.

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Nature Reviews Endocrinology @natrevendo.nature.com · 19/06/2026

This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion (£) bit.ly/3QbxuyL #MedSky #EndoSky

Figure showing mechanisms that regulate glucagon secretion.

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Nature Reviews Endocrinology @natrevendo.nature.com · 18/06/2026

In our July issue, Henning T. Langer et al comment on the causes of sarcopenia and frailty in people taking GLP1RAs (£) go.nature.com/4fQ6XBr #MedSky #EndoSky

Figure showing a summary of the weight loss differences between young and older people.

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Nature Reviews Endocrinology @natrevendo.nature.com · 18/06/2026

From our July issue: Nicola Guess et al outline the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions (£) go.nature.com/4vWluQC #EndoSky #MedSky

Figure showing a contextual overview of the role of hyperinsulinaemia in obesity and related conditions at the population level.

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