Placebo effects are only part of the story. Our new review argues that antidepressant trial outcomes are also influenced by diagnostic uncertainty, illness trajectory, measurement variability, and functional unblinding, with important implications for drug development.
doi.org/10.1176/appi...
doi.org
Determinants of Nonspecific Response to Treatment in Randomized Controlled Trials of Major Depressive Disorder: A Narrative Review | American Journal of Psychiatry
The design, conduct, and interpretation of double-blind randomized placebo-controlled
clinical trials in major depressive disorder (MDD) are complicated by determinants
of nonspecific response to trea...
