Interpreting transcript diversity requires moving beyond ‘known’ versus ‘novel’ and towards a multidimensional framework based on technical credibility, contextual prevalence, reproducibility, molecul...

Somatic small variants in cancer genomes are identified in both short-read and long-read data.

Calibration-aware evaluation of perturbation models shows that deep learning models can outperform baselines.

Reference materials should be adopted as a common calibrator for multiomics measurement and co‑profiled with study samples. Multiomics results should be reported as sample‑to‑reference ratios so that ...

Transient expression of a transcription activator-like effector (TALE)-based epigenetic editor demonstrates durable therapeutic silencing in non-human primates.

Nature Biotechnology - Biotech news from around the world

Lipid nanoparticles often show reduced performance when delivering the large messenger RNAs that encode gene editors. Screening ionizable lipids with a gene-editor-sized RNA identified LC-1, which for...

A scalable blueprint for postdoctoral training embeds entrepreneurial venture mechanics and industry mobility directly into academic infrastructure to cultivate ‘T-shaped’ scientific leaders.

Stem cell differentiation is controlled by manipulating RNA condensates.

Recent moves of note in and around the biotech and pharma industries.

Nature Biotechnology - On-demand glycemic control by engineered bacteria

A novel genetic toolkit may improve the study of how Clostridia bacteria in the gut contribute to disease and reveal new molecular mechanisms that may serve as effective therapeutic targets, as detail...

AGENT, an AI-driven framework integrating high-throughput experimentation with Bayesian optimization, enables the rapid engineering of thermostable, solid-state mRNA vaccines. These formulations retai...

DIAL designs synthetic promoters for generation of heritable setpoints of gene expression across a range of cell types.

Scientists uncover thousands of previously missed proteins, many of which appear to be relevant to human health — including promising new targets for cancer immunotherapies.

Lipid nanoparticles are improved by including RNA cargo size in the design process.

The thermostability of RNA vaccines is improved with AI.

A photolabile oligonucleotide system enables spatially resolved single-cell measurements to show how the epigenome regulates gene expression.

Recent patents relating to systems, methods and compositions for use in synthetic biology.

Nature Biotechnology - New model for industry PhDs

Sustained epigenetic silencing in monkeys is made more efficient with optimized regulators.

Researchers applied six proteomic aging clocks to serum samples from a phase 2a trial of rentosertib in people with idiopathic pulmonary fibrosis and found treatment-associated shifts toward younger p...

A breast cancer drug linked with a test to detect ESR1 mutations in circulating tumor DNA is one of a wave of new drugs developed to tackle resistance to estrogen-receptor-targeted therapies.

Guidance for optimizing lipid nanoparticle formulations is derived using sophisticated biophysical techniques.

In 2025, Insilico Medicine developed an experimental drug called rentosertib as a treatment for idiopathic pulmonary fibrosis, a severe age-related lung disease. The drug works by inhibiting the prote...

An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development.

Nature Biotechnology - Biomimetic cells for studying T cell mechanotransduction

Interpreting transcript diversity requires moving beyond ‘known’ versus ‘novel’ and towards a multidimensional framework based on technical credibility, contextual prevalence, reproducibility, molecul...

Nature Biotechnology - FDA approves oncolytic virus

A Nature Biotechnology phase 2a trial ran six proteomic aging clocks simultaneously, here's what that means for biomarker strategy and FDA submission readiness.

The FDA cannot approve generic drugs for marketing until brand-name drug patents on its list expire or are successfully challenged, but courts have recently found that certain device-only patents are ...

A new generation of RNA therapies delivered by lipid nanoparticles takes aim at extrahepatic tissues.

Six proteomic clocks detect a younger biological age signal in an IPF trial – but separating geroprotection from treatment remains key.

While technologies for smaller gene edits, such as base editing, have already entered clinical trials, larger gene cargoes face different challenges, including low editing efficiencies, delivery vehic...

Mutation of conserved prolines enhances correct pairing of light and heavy chains for bispecific IgG-like antibody production.

Researchers testing out CRISPR systems found that their ability to disrupt gene expression was artificially enhanced by an issue with a measurement technique.

An experimental fibrosis drug designed by artificial intelligence appears to have lowered patients' biological age while also treating their lung disease, according to an analysis of trial blood sampl...

Nature Biotechnology - AI-guided design of complete bacteriophage genomes

A breast cancer drug linked with a test to detect ESR1 mutations in circulating tumor DNA is one of a wave of new drugs developed to tackle resistance to estrogen-receptor-targeted therapies.

MOSAIC is a high-throughput gene synthesis method driven by hybridization (the self-assembly of complementary oligonucleotides during thermal annealing) instead of enzymatic processing. By using the f...

A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.

Models were used to quantify the carbon emissions of industrial or agricultural processes and the effects on air quality on human wellbeing.

Six proteomic aging clocks found rentosertib lowered predicted biological age in 42 lung fibrosis patients. The smaller dose gave the broadest signal.

China’s Decree 818 aims to bring hospital-based cell, gene and individualized therapies into the clinic safely. Its success will depend on whether it is consistently applied and whether adverse outcom...

A versatile nanopore sensor, created by modifying a bacterial porin, enables the simultaneous identification of amino acids, nucleoside monophosphates, saccharides and peptides. Coupled with machine learning, it achieves 98.7% classification accuracy and enables the compositional analysis of native glycopeptides.

Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

Penn Engineers have developed a powerful RNA-guided DNA-cutting protein and are using AI to explore its potential as an alternative to CRISPR-Cas systems.