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Ying Zhu @nanopots.bsky.social · 22/03/2026

Agree, we have used this setting for most of low input DIA proteomics analysis

Reposted by Ying Zhu

PastelBio @pastelbio.bsky.social · 26/02/2026

Systematic Evaluation of Data-independent Acquisition Workflows for High-Throughput and Low-Input Proteomics Analysis with an Astral Mass Spectrometer pubs.acs.org/doi/10.... --- #proteomics #prot-paper

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Reposted by Ying Zhu

kmechtler.bsky.social @kmechtler.bsky.social · 28/01/2026

It is my great honor to announce that registration for the 7th ESCP Single Cell Proteomics Conference is now open: lnkd.in/e4iyiQjf With around 250 participants, it is one of the largest SCP conferences worldwide. We are also proud to announce that there is no participation fee for our conference.

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Reposted by Ying Zhu

Alejandro Brenes @ajbrenes.com · 27/07/2025

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

biorxiv.org

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...

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Ying Zhu @nanopots.bsky.social · 03/05/2025

If it only live for 12-24 hours, how we can call it senescence?

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Reposted by Ying Zhu

Mann Lab @mannlab.bsky.social · 16/04/2025

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. www.nature.com/articles/s41...

nature.com

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature

High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

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Ying Zhu @nanopots.bsky.social · 21/03/2025

Learn most of proteomics knowledge from MaxQuant training videos on YouTube

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Ying Zhu @nanopots.bsky.social · 16/03/2025

Exciting to share a new low-input proteomics technology for unbiased profiling cell surfaceome. The nanoMAPS miniaturizes bead-based AP-MS inside a single droplet, a key step in extending sensitive proteomics from global to functional measurement. www.biorxiv.org/content/10.1...

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Ying Zhu @nanopots.bsky.social · 04/02/2025

Very important study to allow the light cell fixation for single cell proteomics!!! Results are very promising!

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Ying Zhu @nanopots.bsky.social · 22/12/2024

Perfect couple of DESI with microPOTS spatial proteomics! Glad to see microPOTS and DDM protocols received more uses

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Ying Zhu @nanopots.bsky.social · 20/12/2024

DDM may not the best to make bubbles, but definitely the best to get your peptide off from the tubes

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Reposted by Ying Zhu

US HUPO @us-hupo.org · 18/12/2024

We’re thrilled to present "We Are the Analyzers" – an anthem for the proteomics community! A huge shoutout to everyone who brought this incredible song to life. Look what proteomics has already shown us 🎶🧪youtu.be/wzmJDNmsWK8 #Proteomics #USHUPO20YRS

youtu.be

We Are the Analyzers - Proteomics Anthem

We Are the Analyzers - A Proteomics Anthem by US HUPO.

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Ying Zhu @nanopots.bsky.social · 06/12/2024

The main idea behind this is to use transcript reference mapping to assign the cell types, and then do proteomics DE analysis to avoid the double dipping. So external single cell databases also take into considerations

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Ying Zhu @nanopots.bsky.social · 06/12/2024

After long-time review, #nanoSPLITS is finally published. I am deeply grateful to my colleagues who made this work possible, especially @cajunscience.bsky.social. I am also grateful to the support of our single-cell proteomics community during the peer review on Nature Communication!

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Ying Zhu @nanopots.bsky.social · 04/12/2024

I have more questions on Figure 4. Seems IonQuant and Maxquant can not give correct estimates of spike-in protein abundance. I am not sure if it is a normalization issue or FDR control issue.

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Ying Zhu @nanopots.bsky.social · 03/12/2024

It is a great/beautiful study to push the low input proteomics to clinical space. I do agree the title is misleading, it should name as “single cell type proteomics” or “cell type specific proteomics”

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Ying Zhu @nanopots.bsky.social · 28/11/2024

Congratulations @proteomicsnews.bsky.social, can not wait to see more exciting single cell studies from your lab

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Reposted by Ying Zhu

kmechtler.bsky.social @kmechtler.bsky.social · 21/11/2024

It gives me great pleasure to announce our next European Single Cell Proteomics Conference www.apma.at/6thescp/ We would be delighted to receive many abstracts from students so that they have the opportunity to give their first presentation. On behalf of: Erwin, Fabian, Manuel, Fabian and Karl

apma.at

6th ESCP 2025 – APMA

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Ying Zhu @nanopots.bsky.social · 18/11/2024

As I moved my focus to more scientific questions, I prefer to have less identification, better quantification, and more trustworthy data. It is super expensive to validate each proteins for downstream study

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Ying Zhu @nanopots.bsky.social · 17/11/2024

I will try to get him here

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Ying Zhu @nanopots.bsky.social · 16/11/2024

Such a tool is in great need. Will dig into this paper! Thanks for sharing

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