Triple-negative breast cancer (TNBC) develops in hypoxic, nutrient-limited tumors enriched with macrophages and cell death. We show that metabolically distinct TNBCs differentially exploit macrophage-...

imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective standard conditions reveals common and distinctive metabolic signatur...

Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their metabolic activity and cytotoxicity.