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Jacob Nadel

@nadelneurosci.bsky.social
494 followers 216 following 12 posts

PhD candidate in the Lerner Lab at Northwestern | Oberlin College ‘19 | Stress, basal ganglia, amygdala, dopamine

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Reposted by Jacob Nadel
Dr. Cate Peña @cate-cholamine.bsky.social · 07/08/2026
So proud to have “Early-life stress alters H3K4me1 in VTA to prime stress sensitivity” out now in Neuron! This work spanned Many years and Many people contributed. Huge thanks to @hyejaykim.bsky.social, @ja-balouek.bsky.social, Luke Geiger, and Meaghan Creed www.cell.com/neuron/fullt...
cell.com
Early-life stress alters H3K4me1 in VTA to prime stress sensitivity
Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...
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Reposted by Jacob Nadel
Talia Lerner @talialerner.bsky.social · 03/08/2026
🚨Happy to share a new preprint from Lerner Lab led by graduate student @nadelneurosci.bsky.social! 🚨 “Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking” This has been a wholly impressive effort by Jacob; summary below 👇 #neuroskyence🧪
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Talia Lerner @talialerner.bsky.social · 03/08/2026
And a second new preprint from Lerner Lab on the same day! 👀 🎉 Led by graduate student Nkatha Mwenda! “Dopamine dips during unrewarded actions promote punishment-resistant reward seeking” #neuroskyence🧪
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Jacob Nadel @nadelneurosci.bsky.social · 03/08/2026
Huge day for the Lerner Lab, Nkatha’s preprint is also up!
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Jacob Nadel @nadelneurosci.bsky.social · 03/08/2026
The bulk of my PhD work is now out as a preprint! Check it out 😁
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Jacob Nadel @nadelneurosci.bsky.social · 08/11/2025
www.nature.com/articles/s41... this paper is AWESOME but how is this DLS and not tail??
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Jacob Nadel @nadelneurosci.bsky.social · 19/09/2025
Check this out!!!
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Jacob Nadel @nadelneurosci.bsky.social · 22/04/2025
Go Gaby!!! The superest star!!! @glopez.bsky.social
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Reposted by Jacob Nadel
Tom Kash @superkash.bsky.social · 22/04/2025
dopamine sometimes tell you nopamine?
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Gerry Canavan @gerrycanavan.bsky.social · 22/03/2025
every college, corporate, and nonprofit president right now
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Gabe Loewinger @gabeloewinger.bsky.social · 18/03/2025
Test effects of behavior/events at every trial timepoint in photometry analyses! Paper with Erjia Cui, Dave Lovinger, Francisco Pereira. “A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments.” Python+R packages! elifesciences.org/articles/95802. 1/13
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Jacob Nadel @nadelneurosci.bsky.social · 19/03/2025
Awesome work from an amazing set of labs and institution!
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Reposted by Jacob Nadel
Christopher Howard @howarddopamine.bsky.social · 24/01/2025
How quickly can rodents adapt to changes in time durations in their environment? Work from @oberlincollege.bsky.social suggests they can recognize and respond extremely quickly, hinting at a rapid mechanism for learning about time in the brain. link.springer.com/article/10.1...
link.springer.com
Rats and mice rapidly update timed behaviors - Animal Cognition
Keeping track of time intervals is a crucial aspect of behavior and cognition. Many theoretical models of how the brain times behavior make predictions for steady-state performance of well-learned int...
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Reposted by Jacob Nadel
Adam Van Arsdale @apv2600.bsky.social · 08/02/2025
My feed is overwhelmed with scientists right now calling out the catastrophic consequences of the NIH indirect cost order from last night. If those same people aren't also speaking out against the anti-trans, anti-DEI, anti-immigrant orders...we are lost. The only path forward is solidarity.
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Russ Poldrack @russpoldrack.org · 08/02/2025
Great analysis of the indirect cost rate announcement by @stuartbuck.bsky.social
open.substack.com
Indirect Costs at NIH . . .
I wasn’t planning on spending part of a Saturday writing about cost accounting principles and the like, but NIH-world was hit with a doozy of a policy announcement on Friday night:
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Emily Prevost @emilyprevost.bsky.social · 07/02/2025
Honored to receive first place poster award at #wcbr2025! Thanks to all who stopped by. The poster (and my panel) explored divergent signaling dynamics in VTA dopamine subpopulations, as well as functional roles for glutamate and dopamine in co-transmitting VTA neurons. Stay tuned for more!
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Jacob Nadel @nadelneurosci.bsky.social · 30/01/2025
Had SUCH an amazing time at my first #wcbr — so grateful for the opportunity! It was so great to see friends new and old. Hope to be in #Bigsky next year!
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Reposted by Jacob Nadel
Ashley Holloway @ashleyholloway.bsky.social · 09/12/2024
Hi #ACNP2024! I'm a postdoc in Reesha Patel's lab at Northwestern, and this is my first in-person ACNP 🎉 I'm presenting a poster on Monday (M157) on VTA 🌟astrocyte 🌟 activity during appetitive and aversive conditioning!
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Les Shireman @lessh58.bsky.social · 04/12/2024
Big Supreme Court argument today regarding the right of trans kids to get proper medical care. This matters. Diminishing the rights of one group diminishes the rights of all us. #transrightsmatter
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Jacob Nadel @nadelneurosci.bsky.social · 04/12/2024
Very excited for this! Sign up, it’s free and online!
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Ben Natan @thebennatan.bsky.social · 29/11/2024
The Anti-Trans Athlete Panic is a jobs program for the world’s shittiest athletes.
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Jeremy Day @daylab.bsky.social · 29/11/2024
Excited to see this review manuscript from lab MD/PhD student Dalton Fitzgerald officially out in Addiction Neuroscience! www.sciencedirect.com/science/arti...
sciencedirect.com
Neuronal heterogeneity in the ventral tegmental area: distinct contributions to reward circuitry and motivated behavior
The ventral tegmental area (VTA) is a critical component of brain reward circuitry that influences motivation, learning, and emotional regulation. Alt…
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Reposted by Jacob Nadel
Black In Neuro @blackinneuro.bsky.social · 15/11/2024
#BlackInNeuro Starter Pack v1! Let us know if we missed you. #BlackInSTEM #Neuroscience 🧪 go.bsky.app/F8PpdPe
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Jacob Nadel @nadelneurosci.bsky.social · 15/11/2024
My main postbac project is published! In collaboration with the late great Richard Veech, we tested how ketone-ester enriched chow impacted the progression of motor and dopamine deficits in the MitoPark mouse model. Find out more here! doi.org/10.1111/ejn....
doi.org
Ketone ester–enriched diet ameliorates motor and dopamine release deficits in MitoPark mice
MitoPark mice, a model of Parkinson's disease, fed a ketone ester–enriched diet had moderate improvements in locomotor performance on open field and rotarod behavioural tasks. This behavioural improv....
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Jacob Nadel @nadelneurosci.bsky.social · 15/11/2024
Nadel: it’s bedtime
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