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Michael Weintraub, MD

@mweintraubmd.bsky.social
256 followers 228 following 126 posts

Endocrinologist & Clin. Asst. Prof. @NYULangone | @WeillCornell and @Sloan_Kettering endocrine fellow alum. Opinions=own #MedSky #EndoSky

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Michael Weintraub, MD @mweintraubmd.bsky.social · 09/05/2026
❓ What are the health impacts of weight regain immediately prior to pregnancy or in early pregnancy? How do we maximize benefits while mitigating risks? Limited and conflicting data exist. pubmed.ncbi.nlm.nih.gov/42083106/ 📖 Read our perspective newly published in Obesity.
pubmed.ncbi.nlm.nih.gov
Glucagon-Like Peptide-1 Receptor Agonists: Considerations for Treating Preconception Obesity - PubMed
Glucagon-Like Peptide-1 Receptor Agonists: Considerations for Treating Preconception Obesity
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Reposted by Michael Weintraub, MD
conscienhealth.bsky.social @conscienhealth.bsky.social · 06/04/2026
In new clinical guidance, @endosocjournals.bsky.social says Lancet Commission work on #ClinicalObesity is a meaningful advance, but has practical issues. Lancet author Francesco Rubino says they're mistaken. Dialogue & collab needed. HT: @mweintraubmd.bsky.social conscienhealth.org/2026/04/06/u...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 05/04/2026
💉 In a large real-world study, tirzepatide was associated with a lower incidence of major cardiovascular outcomes vs semaglutide: 📊 Composite CV outcome: 1.90% vs 2.18% (HR 0.86, p=0.01) ❤️ New-onset heart failure: 1.04% vs 1.29% (HR 0.79, p=0.002) dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 03/04/2026
⚖️ The Commission made a genuine advance, moving beyond BMI toward a more nuanced, adiposity-based diagnosis. But does the framework hold up under scrutiny?
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Reposted by Michael Weintraub, MD
Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts www.statnews.com/2026/04/02/b... via @statnews.com
statnews.com
Proposed ‘preclinical obesity’ diagnosis ignites global debate among experts
A new way to define obesity aims to sharpen the diagnosis. Critics warn it could delay care, exclude diabetes, and deepen inequities in accessing treatment.
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Reposted by Michael Weintraub, MD
Ranganath Muniyappa @muniyappar.bsky.social · 02/04/2026
New Endocrine Society guideline communication appraises the The Lancet Commission obesity framework. We explore implications for practice and policy. Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework url: academic.oup.com/jcem/article...
academic.oup.com
Defining disease or delaying care? A conceptual and clinical appraisal of the Lancet obesity framework
Abstract. The Lancet Diabetes & Endocrinology Commission undertook the complex task of addressing limitations in existing definitions and classificatio
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Michael Weintraub, MD @mweintraubmd.bsky.social · 27/03/2026
Today the FDA approved the first once-weekly insulin. Insulin icodec, now brand name Awiqli, demonstrated superior a1c reduction to daily insulin glargine with a1c reduction of 1.55% compared to 1.35%, in addition to 6 less injections per week in the ONWARDS phase 3 trial.
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Michael Weintraub, MD @mweintraubmd.bsky.social · 23/02/2026
You know the protein craze is getting too much when protein-infused Pop Tarts are on the shelves. conscienhealth.org/2026/02/23/m...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 11/02/2026
There are multiple methods to estimate body composition, each with their pros and cons. www.mdpi.com/2075-1729/14...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 09/02/2026
DEXA-derived estimates of abdominal adiposity in postmenopausal women was a better predictor of cardiometabolic disease than traditional surrogates (BMI, waist circumference, waist-to-hip ratio) in older women. pubmed.ncbi.nlm.nih.gov/34479738/
pubmed.ncbi.nlm.nih.gov
DXA Versus Clinical Measures of Adiposity as Predictors of Cardiometabolic Diseases and All-Cause Mortality in Postmenopausal Women - PubMed
DXA-derived estimates of abdominal adiposity in postmenopausal women may allow for substantially improved risk prediction of diabetes over standard clinical risk models. Larger DXA studies with…
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Michael Weintraub, MD @mweintraubmd.bsky.social · 03/02/2026
CagriSema demonstrates a1c reduction of 1.9% and weight loss of 14.2% in adults with type 2 diabetes, reported from the REIMAGINE 2 top-line data this week.
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Michael Weintraub, MD @mweintraubmd.bsky.social · 25/01/2026
Automated insulin delivery, the integration of insulin pump with continuous glucose monitor is now the standard of care for Type 1 Diabetes 🤖💉📈 Why? It’s clearly superior in attaining greater diabetes control by way of Time In Range ⏱️🩸✅ researchprofiles.ku.dk/en/publicati...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/01/2026
Milestones in research related to the pathophysiology of the incretin hormones GIP and GLP-1 as parent compounds for incretin-based medications for treatment of type 2 diabetes and clinical obesity pubmed.ncbi.nlm.nih.gov/41547366/
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Michael Weintraub, MD @mweintraubmd.bsky.social · 14/01/2026
What's new in ADA Standards of Care 2026? Inclusion of continuous glucose monitoring (CGM) data when monitoring for disease progression among individuals with presymptomatic type 1 diabetes. Recommendation 3.2 ADA Standards of Care 2026 diabetesjournals.org/care/article...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 12/01/2026
Mild autonomous cortisol secretion (MACS) is not a benign condition. MACS carries increased risk of mortality with HR 1.52-1.77 compared to those with non-functioning adenomas, with death from cardiovascular disease, cancer and infection.
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Michael Weintraub, MD @mweintraubmd.bsky.social · 09/01/2026
How to manage Post-Bariatric Hypoglycemia (BPH), according to a new consensus statement
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Michael Weintraub, MD @mweintraubmd.bsky.social · 07/01/2026
Mild autonomous cortisol secretion (MACS) traditionally viewed as part of the continuum of Cushing syndrome is recognized as a distinct entity. Only <1% of MACS processes to overt Cushing syndrome. Genetic mutations for MACS and Cushing syndrome is different www.vumedi.com/video/when-a...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 26/11/2025
Anabolic therapies hold tremendous potential for the treatment of osteoporosis. 💪🦴 Currently all treatments are injectables, but the are oral options on the horizon. 💉➡️💊 pubmed.ncbi.nlm.nih.gov/38578978/
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Michael Weintraub, MD @mweintraubmd.bsky.social · 24/11/2025
A practical side-by-side comparison of the Tymlos and Forteo, the two anabolic PTH receptor agonists for osteoporosis. Presented by Dr. Bilezikian
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Michael Weintraub, MD @mweintraubmd.bsky.social · 23/11/2025
In a world where a publication becomes outdated immediately after it's published, a recent systemic review shows incretin-based medications dominate clinical trial development. But they are not the only potential mechanism. pubmed.ncbi.nlm.nih.gov/40993341/
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Michael Weintraub, MD @mweintraubmd.bsky.social · 24/09/2025
We should be screening everyone with hypertension for primary aldosteronism, according to the recently released Endocrine Society guidelines. Follow this diagnostic algorithm Full guidelines: academic.oup.com/jcem/article...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 19/09/2025
How to individualize obesity medication treatment depending on obesity-related conditions. Great summary by the newly released update to the AACE Evaluation and Treatment of Adults with Obesity 2025 Consensus Statement www.endocrinepractice.org/article/S153...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 08/09/2025
Developing clinical practice guidelines is quite a process. The GRADE format methodology translates evidence to medication decision-making recommendations after performing systemic review of the available evidence. www.bmj.com/content/389/...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 25/08/2025
A higher BMI is correlated with increased risk of overall mortality. It follows the same overall curve as higher cholesterol and blood pressure, as illustrated in these graphs 📈 Controlling any and all of these risk factors lowers our overall risk of death. pubmed.ncbi.nlm.nih.gov/28489290/
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/08/2025
Obesity rates have skyrocketed starting in the 1970s now reaching 40% in the United States. "It seems highly unlikely that the obesity epidemic can be explained by a widespread drop in willpower happening in the late 1970s." www.cell.com/cell/fulltex...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 18/08/2025
A collection of all my favorite podcasts to stay up to date in Diabetes Care Check out this Marvel-style crossover episode hosted at ADA. overcast.fm/+AABFhuN39pM
overcast.fm
Special Edition - ADA Scientific Sessions 2025 — Diabetes Core Update
In this special edition of Diabetes Core Update we present a special podcast recorded live at the ADA Scientific Sessions by the editors of Diabetes Core Update, Diabetes Care On Air, Diabetes Bio,…
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Michael Weintraub, MD @mweintraubmd.bsky.social · 14/07/2025
Rates of obesity of BMI 30-40 have had a mild increase over the last 20 years. Rates of severe obesity BMI > 60 has dramatically risen- this graph is impressive. Slide by Dr. Satya Dash at #ENDO2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 13/07/2025
Pheochromocytoma survival curves are dismal, particularly in those with metastatic disease. We need better treatments for these patients. Excellent lecture by Dr. Camilo Jimenez at #ENDO2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 12/07/2025
Multiple benefits of GLP1s in reducing residual risk in those with type 1 diabetes. Excellent talk by Dr. Kaitlin Love at #ENDO2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 12/07/2025
GLP1 agonism prevents cardiovascular disease through both direct and indirect vascular effects #ENDO2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 12/07/2025
Studies showing benefits of GLP1 agonists in type 1 diabetes are accumulating. Modest A1c reduction but impressive reductions in total daily insulin dose and weight reduction. #ENDO2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 11/07/2025
Retatrutide may be the most hotly anticipated GLP-1 based medication in development 🔥💊, but others are not far behind 🏃. A triple agonist, UBT251, is under development in China 🇨🇳 and also mimics GLP-1, GIP, and glucagon 🧬⚗️.
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Michael Weintraub, MD @mweintraubmd.bsky.social · 09/07/2025
“Food noise” is the “incessant mental chatter” or “constant rumination” about food. It is increasingly recognized as a phenomenon particularly with its profound elimination with GLP1 treatment. New Nature review: www.nature.com/articles/s41... Great overview: conscienhealth.org/2025/07/lift...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 05/07/2025
“If you treat someone’s blood pressure or cholesterol you don’t get improvements in quality of life. You treat their weight you get all the benefits." "That is the power of treating obesity.” Inspiring talk by Dr. Lou Aronne on the clinical implications of CagriSema at #ADASciSessions #ADA2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 01/07/2025
The long awaited triple agonist retatrutide phase 3 data is still pending ⏳🧪. However, a body composition subanalysis of the phase 2 data is newly published 📄 showing lean mass loss of 38% of total weight loss 💪📉.
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Michael Weintraub, MD @mweintraubmd.bsky.social · 30/06/2025
The etiology of obesity is most often multifactorial- a combination of environmental factors and genetic predisposition among thousands of genes. However, a portion of cases are due to a single genetic cause, such as in the leptin-melanocortin pathway. academic.oup.com/edrv/article...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 25/06/2025
What is the impact of tirzepatide on body composition? 🤔 There was an absolute loss in lean mass 💪⬇️, however there was a GREATER loss in fat mass 🧈🔥. Thus, there was an increase in lean mass as percent body composition 📊💪. This correlates with what we see clinically
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Reposted by Michael Weintraub, MD
Daniel Drucker @danieljdrucker.bsky.social · 23/06/2025
How should we think about the interesting bimagrumab & Semaglutide data #ADA2025 #weightloss #obesity How to assess meaningful functional benefit? www.statnews.com/2025/06/23/b...
statnews.com
Eli Lilly drug preserves lean mass in patients losing weight on Wegovy
Some doctors are concerned that patients taking weight loss drugs like Wegovy may be losing too much lean mass. A combination therapy might change that.
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Reposted by Michael Weintraub, MD
Daniel Drucker @danieljdrucker.bsky.social · 23/06/2025
P2 data for the once monthly GIPR Antagonist GLP-1R agonist bispecific antibody, Maritide in people with #T2D as well as in #overweight and #obesity Even data for lower dose titration over several weeks in the same paper www.nejm.org/doi/full/10....
nejm.org
Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial | NEJM
Maridebart cafraglutide (known as MariTide) is a long-acting peptide–antibody conjugate that combines glucagon-like peptide-1 receptor agonism and glucose-dependent insulinotropic polypeptide recep...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/06/2025
We’ve gone from 2 to over a dozen trials of GLP1s in alcohol use disorders in only a few years. This comes on the heels of numerous observational and pharmacoepidiologic data supporting a reduction in alcohol use in GLP1 users. #ADA2025 #ADASciSessions
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/06/2025
Continuous glucose monitors are an excellent tool… when they work! Studies report up to 26% early failure rate of these devices. #ADA2025 #ADASciSessions
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/06/2025
There is a national shortage of endocrinologists! The majority of the country do not have local access to endocrinologists. 80% of those with diabetes are cared for by a PCP and no endocrinologist. #ADA2025 #ADASciSessions
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/06/2025
The prevalence of type 2 diabetes in the young is rising, and so are the complications. 80% of individuals develop a microvascular complication by 9 years over 9 years of follow-up! #ADA2025 #ADASciSessions
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/06/2025
❗ New CagriSema Phase 3 data released Combination cagrilintide-semaglutide after 68 weeks in patients with Type 2 Diabetes and BMI > 27 ⬇️ 13.7% weight loss vs 3.4% in placebo ⬇️ 1.8% a1c reduction vs 0.4% in placebo 73% had a1c <6.5% 🤢 72.5% had gastrointestinal side effects vs 34% in placebo
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Michael Weintraub, MD @mweintraubmd.bsky.social · 22/06/2025
Tirzepatide in a target emulation trial demonstrates significantly lower MACE (HR 0.8) and all cause mortality (HR 0.6) compared to dulaglutide in T2DM. 🤯 #ADASciSessions #ADA2025
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Michael Weintraub, MD @mweintraubmd.bsky.social · 20/06/2025
CAC > 300 is equivalent to prior ASCVD for risk of future cardiovascular events. One could consider treating someone with CAC > 300 as SECONDARY prevention, not primary prevention. Similar risk = similar therapies. #ADA2025 #ADASciSessions
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Michael Weintraub, MD @mweintraubmd.bsky.social · 17/06/2025
💉 GLP-1s were associated with 23% lower risk of mortality in those with type 2 diabetes on dialysis compared to non-users💡 🙏 Honored to be co-author on this observational analysis of 151,649 dialysis patients with type 2 diabetes, published today 📅 journals.lww.com/cjasn/abstra...
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Reposted by Michael Weintraub, MD
The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 15/06/2025
Martin Fassnacht et al present & discuss the challenges involved in the management of patients with adrenocortical carcinoma, together with their personal recommendations regarding 25 of what they believe are the most crucial clinical questions www.thelancet.com/journals/lan... #EndoSky #OncSky
thelancet.com
Adrenocortical carcinoma: a practical guide for clinicians
Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous but frequently aggress...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 13/06/2025
An argument for reduced dosing frequency of GLP-1s 💉 to maintain long-term weight loss ⚖️, based on mathematical modeling 📊: ➡️ Switching semaglutide from 1x/week to 1x/2 weeks = 50% fewer doses but 72% of weight loss retained ✅ onlinelibrary.wiley.com/doi/10.1002/...
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Michael Weintraub, MD @mweintraubmd.bsky.social · 10/06/2025
💉 Once weekly fixed dose GLP1+insulin is one step closer to approval 💯 Two trials with once weekly basal insulin icodic and GLP-1 receptor agonist semaglutide (IcoSema) were recently published in Lancet. pubmed.ncbi.nlm.nih.gov/40482672/
pubmed.ncbi.nlm.nih.gov
IcoSema and the evolution of fixed-ratio insulin-GLP-1 receptor agonist therapies - PubMed
IcoSema and the evolution of fixed-ratio insulin-GLP-1 receptor agonist therapies
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