Reposted by Farid Moussavi-Harami, MDJournal of Molecular and Cellular Cardiology @jmccardiology.bsky.social · 15/07/2025Work from Patrick Boyle at University of Washington shows population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection Read more: doi.org/10.1016/j.yj... 061
Farid Moussavi-Harami, MD @moussavi-harami.bsky.social · 08/07/2025Great new study with collaboration from the Regnier lab @uwbioe.bsky.social and the Kad lab at the University of Kent in the UK! Very cool spatially resolved single-molecule imaging. @ctmr-uw.bsky.social 2102
Reposted by Farid Moussavi-Harami, MDMichael Levin @mglevin.bsky.social · 08/04/2025Excited to see this published: rdcu.be/egHer Common- and rare-variant genetic analyses of heart failure in >2 million individuals 🔘 Dozens of new common variant loci 🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes 🔘 A PRS modifies penetrance of TTNtvrdcu.beCommon-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrumNature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across... 1153
Reposted by Farid Moussavi-Harami, MDJournal of Clinical Investigation @jci.org · 28/02/2025Regulation of TTN as a mechanism of and treatment for heart failure: buff.ly/4b9AEZy Dominic E. Fullenkamp comments on Yuri Kim et al. (buff.ly/3X7mW3Y) 033
Reposted by Farid Moussavi-Harami, MDPradeep Natarajan @pnatarajanmd.bsky.social · 05/02/2025Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social 2106
Farid Moussavi-Harami, MD @moussavi-harami.bsky.social · 30/12/2024Exciting work from my brother! 092
Reposted by Farid Moussavi-Harami, MDShoa Clarke @shoaclarke.bsky.social · 26/12/2024A coding variant in BAG3 protects against dilated cardiomyopathy but increases risk for hypertrophic cardiomyopathy and is found to modify the effects of pathogenic TTN variants jamanetwork.com/journals/jam...jamanetwork.comBidirectional Risk Modulator Along the DCM-HCM SpectrumThis cross-sectional study evaluates the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). 0225