Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 13/12/2024That's just one way lenacapavir can stop the virus. It's so effective as a therapeutic & prophylactic because it targets multiple stages of the HIV life cycle. Others have shown that it also stops the capsid from entering the nucleus, & disrupts assembly of new capsids. 000
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 13/12/2024Super cool to see @science.org named anti-HIV drug lenacapavir as Breakthrough of the Year. 🧪This breakthrough is underpinned by a wealth of basic research. Our contribution is to show how the drug cracks the protective HIV capsid 👇https://doi.org/10.7554/elife.83605doi.orgPharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failureThe anti-HIV drug lenacapavir breaks the HIV capsid by stabilising regions of low curvature at the expense of maintaining a closed shell, leading to loss of viral DNA synthesis and inhibition of infec... 294
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 26/11/2024Thanks for pointing this out. New link: www.nature.com/articles/s41... 110
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 18/11/2024Hi Johannes, could you please add us? 110
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 25/01/2024The #HIV capsid mimics host chaperones to gain access into the nucleus, solving a long-standing mystery – David Jacques' team published in Nature. @singmolsci.bsky.social #UNSWSBMS 🔗 nature.com/articles/s41... 🎨: Jon Berengut 1146
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 28/11/2023We've still taking applications to join our team @singmolsci.bsky.social. Now closing 10Dec2023 🔗 external-careers.jobs.unsw.edu.au/cw/en/job/52... 064
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 28/11/2023🚨preprint @biorxivpreprint.bsky.social We use #SingleMolecule🔬to see how a capsid-targeting antiviral (lenacapavir) hacks assembly of the HIV capsid, which normally protects the #HIV genome. Now also with real-time visualization of the drug breaking open the capsid. www.biorxiv.org/content/10.1...biorxiv.orgPharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failurebioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 011
Molecular Machines & Structural Virology Group @molecmachines.bsky.social · 08/11/2023🚨Join us at UNSW Sydney! We're searching for a postdoc to join our team to investigate dynamics of host-pathogen interactions🦠. #SingleMolecule #microscopy🔬 Apply by 26Nov2023. Please share 🔗https://external-careers.jobs.unsw.edu.au/cw/en/job/520570/post-doctoral-fellow-hostpathogen-biophysics 062