Super cool to see @science.org named anti-HIV drug lenacapavir as Breakthrough of the Year. 🧪This breakthrough is underpinned by a wealth of basic research. Our contribution is to show how the drug cracks the protective HIV capsid 👇https://doi.org/10.7554/elife.83605
doi.org
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
The anti-HIV drug lenacapavir breaks the HIV capsid by stabilising regions of low curvature at the expense of maintaining a closed shell, leading to loss of viral DNA synthesis and inhibition of infec...
