The aerobic ancestry of mitochondria is unveiled with multiple approaches.

Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and ...

Mitochondria are cellular organelles critical for ATP production and are particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia reperfusion injury, and car...

This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.

Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the fundamental mechanisms of physiologic aging are poorly un...

Patrick Vallance, Chris Witty and others reflect on advising the UK government during the ongoing investigation into the country’s pandemic response. Patrick Vallance, Chris Witty and others reflect...

Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the fundamental mechanisms of physiologic aging are poorly un...

medRxiv - The Preprint Server for Health Sciences

Hargreaves and Spriet review regulatory mechanisms of ATP resynthesis during exercise and summarize nutritional interventions that target muscle metabolism to enhance athletic performance.

Hargreaves and Spriet review regulatory mechanisms of ATP resynthesis during exercise and summarize nutritional interventions that target muscle metabolism to enhance athletic performance.

It is widely reported that the mitochondrial membrane potential, ∆Ψm, is reduced in aging animals. It was recently suggested that the lower ∆Ψm in aged animals modulates mitochondrial bioenerget...

Exhaustion is the functional deterioration of T cells following chronic stimulation. Here, Wu et al. show that mitochondrial dysfunction drives T cell exhaustion by inhibiting HIF-1α degradation and ...

In biology, there are no good or evil molecules. There is limited or no evidence to support the consumption of antioxidants or (super)foods rich in an…

In biology, there are no good or evil molecules. There is limited or no evidence to support the consumption of antioxidants or (super)foods rich in an…

Molecular analyses of modern and fossil skeletal samples reveal that elevated metabolic rates consistent with endothermy evolved independently in mammals and plesiosaurs, and ornithodirans: ...

The discovery that ATP synthesis is powered by proton gradients was one of the most counterintuitive in biology. The mechanisms by which proton gradients are formed and coupled to ATP synthesis are kn...

The discovery that ATP synthesis is powered by proton gradients was one of the most counterintuitive in biology. The mechanisms by which proton gradients are formed and coupled to ATP synthesis are kn...