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Mitchell Dumais, MD

@mitchdumais.bsky.social
942 followers 1.9K following 121 posts

Infectious Diseases Fellow in Washington, DC by way of @MayoClinic and @UWMedicine. Interests in #Virology, #HIV, #GeneTherapy, #Immunology and #Biodefense. Amateur brewer, fisherman, cat dad. 🩺🦠🧬💊💉 All views/posts are my own.

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Reposted by Mitchell Dumais, MD
NEJM.org @nejm.org · 07/10/2026
Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. Full phase 3 ISLEND-1 trial results: nej.md/4b4s7sh
This image contains an excerpt from the Research Summary "Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment" published in the New England Journal of Medicine. It shows participant statistics: 607 adults, median age 49 years, 20.6% designated female at birth. It features illustrations of two treatment options: Islatravir–Lenacapavir (ISL/LEN) (304 participants) and Bictegravir–Emtricitabine–Tenofovir Alafenamide (B/F/TAF) (303 participants). A prompt to read the full Research Summary at NEJM.org sits at the bottom.
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Reposted by Mitchell Dumais, MD
Tom Nichols @radiofreetom.bsky.social · 06/10/2026
What's going on with this plague death in #Russia? Whatever it is, don't count on Moscow to be honest about it: www.theatlantic.com/ideas/2026/1...
theatlantic.com
Russia Needs to Tell the Truth About a Plague Death
After an apparent lab accident in Siberia, Moscow is reverting to its old Soviet ways.
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Reposted by Mitchell Dumais, MD
Nature @nature.com · 24/09/2026
AlphaFold is being upgraded to better represent some of the least known and deadliest species: viruses go.nature.com/4cZivjx
go.nature.com
AlphaFold 'goes viral': database adds protein complexes of common viruses
AI predictions could help with pandemic preparedness, but they will need experimental confirmation.
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Reposted by Mitchell Dumais, MD
Kristian G. Andersen @kgandersen.bsky.social · 11/09/2026
Good read. What truly baffles me seeing this "AI-designed-printed-in-the-lab-bioweapon will kill us all" guff is the fact that we have *the* biggest, out-of-control, Gain-of-Function experiment, in BSL-0, already running rampant in the US. In cattle 🐮. Yet, 🦗. www.theatlantic.com/health/2026/...
theatlantic.com
The AI Pandemic Isn’t On Its Way
Yet plenty of others might be, thanks to evolution.
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Reposted by Mitchell Dumais, MD
Jonathan Ryder, MD @jonathanrydermd.bsky.social · 08/09/2026
New Scientific Statement from AHA on Endocarditis!! This is as close as it gets to a new IE guideline POET criteria for PO switch, no more gent for Staph PVE, monotherapy for Staph PVE after valve replacement, ceftriaxone monotherapy for Pen-I Strep, and more!! www.ahajournals.org/doi/10.1161/...
ahajournals.org
Infective Endocarditis: Diagnosis, Antibiotic Therapy, and Management: A Scientific Statement From the American Heart Association | Circulation
Since the publication of the 2015 American Heart Association scientific statement on infective endocarditis, its incidence has increased, its epidemiology has changed, and novel diagnostic and treatme...
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Reposted by Mitchell Dumais, MD
Open Forum Infectious Diseases @ofidjournal.bsky.social · 27/08/2026
Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023 ✅ Just Accepted ⭐ Editor's Choice bit.ly/4zGLDWk
doi.org
Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023
AbstractBackground. Chronic Q fever, caused by Coxiella burnetii, presents significant diagnostic and management challenges due to its variable presentatio
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Mitchell Dumais, MD @mitchdumais.bsky.social · 28/08/2026
Now FDA approved! Bictegravir-Lenacapavir (BIC/LEN) daily pill for HIV+ patients who are suppressed and likely on more complex regimens. Another option for patients with kidney disease, NNRTI/NRTI resistance. Trial Here: ARTISTRY-1: The Lancet www.thelancet.com/journals/lan...
thelancet.com
Switch to single-tablet bictegravir–lenacapavir from a complex HIV regimen (ARTISTRY-1): a randomised, open-label, phase 3 clinical trial
Bictegravir–lenacapavir STR demonstrated non-inferior efficacy to complex regimens, with a similar safety profile and increased treatment satisfaction. Bictegravir–lenacapavir offers new opportunities...
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Reposted by Mitchell Dumais, MD
Library of Congress @librarycongress.bsky.social · 25/08/2026
The Library is devastated to learn of the passing of Dolly Parton, a music legend and titan of children's literacy. Her Imagination Library program has earned multiple Library Literacy Awards and, in 2018, she visited us to donate its 100 millionth book to our collection and host a story time. 🦋❤️
Dolly Parton reads to children in the Library’s Great Hall in 2018. Photo by Shawn Miller.
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Mitchell Dumais, MD @mitchdumais.bsky.social · 22/08/2026
I had never thought of this and had to look it up! IAS-USA does recommend for PrEP start with TDF/FTC to do a double dose up front and then daily dosing, but no recommendation for TAF/FTC. If starting TDF/FTC will think of this now.
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Mitchell Dumais, MD @mitchdumais.bsky.social · 22/08/2026
Thank you!
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Mitchell Dumais, MD @mitchdumais.bsky.social · 22/08/2026
Thank you! It was a nice team effort 😀
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Mitchell Dumais, MD @mitchdumais.bsky.social · 22/08/2026
Thats some of the signal we found in our group - a sizeable amount stopped the HCQ due to side effects as well, and doxy was easier to tolerate. But its a small sample size still and very diverse in presentations, so hard to draw many firm conclusions.
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Mitchell Dumais, MD @mitchdumais.bsky.social · 21/08/2026
With Q Fever, there are often too many questions! So excited to share this project after many years of work with my colleagues from Mayo ID. Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023 academic.oup.com/ofid/article...
academic.oup.com
Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center from 2007 to 2023
AbstractBackground. Chronic Q fever, caused by Coxiella burnetii, presents significant diagnostic and management challenges due to its variable presentatio
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Reposted by Mitchell Dumais, MD
CIDRAP @cidrap.bsky.social · 21/08/2026
Is mpox here to stay? CDC study says virus is likely becoming endemic After a surge in 2022, the virus is now spreading continuously among US residents. Read more: bit.ly/4wJRR5d 📷: NIAID/NIH
Viral particles of mpox, stained blue for clarity.
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Reposted by Mitchell Dumais, MD
Eric Topol @erictopol.bsky.social · 19/08/2026
mRNA vaccines vs cancer success —melanoma (Phase 3, RCT, definitive, announced today) —triple negative breast cancer —pancreatic cancer —non-small cell lung cancer —glioblastoma
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Reposted by Mitchell Dumais, MD
BK. Titanji @boghuma.bsky.social · 13/08/2026
Pretty wild MMWR. A woman with a new diagnosis of HIV who was still breastfeeding her 2 year old and donating milk online via Facebook triggered a public health investigation. Her HIV VL was 119,000 copies per/ml. Thankfully no new infections occurred. www.cdc.gov/mmwr/volumes...
cdc.gov
Notes from the Field: Potential Infant HIV Exposure ...
This report describes a possible HIV exposure from donated breast milk received through social media.
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Reposted by Mitchell Dumais, MD
Carl Zimmer @carlzimmer.com · 06/08/2026
Here's a new kind of virus that scientists have generated with AI. And here's my story about what it means for us to have gotten to this remarkable moment: nyti.ms/4bBhoWB (Gift link) 🧪
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Reposted by Mitchell Dumais, MD
Kathleen Bachynski @bachynski.bsky.social · 31/07/2026
“These DNA fragments have prompted scientists to think about smallpox in a new light. It may not have begun as the dreaded killer we think of it as today. It’s possible that it was a relatively mild infection for centuries, taking many generations to evolve into Jenner’s dreadful scourge.”
nytimes.com
‘This Is Very Strange’: Ancient Smallpox May Have Been Less Deadly
Scientists have found smallpox viruses in the remains of people in Chile from around 500 years ago, revealing how the virus may have evolved into a global killer.
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Reposted by Mitchell Dumais, MD
NEJM.org @nejm.org · 29/07/2026
Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. Full phase 3 ISLEND-1 trial results: nej.md/4b4s7sh #AIDS2026
A bar chart from the Original Article "Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment." The trial name, ISLEND-1, is in parentheses after the title. The chart shows virologic outcomes at week 48. The trial results are being presented at the International AIDS Conference. The logo of the New England Journal of Medicine is at the bottom.
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Mitchell Dumais, MD @mitchdumais.bsky.social · 29/07/2026
Cautionary tale to know what is in your freezer... And another reason why in the clinic, MALDI and other advanced techniques for identification are so critical.
arstechnica.com
College lab class ends with 32 people on antibiotics for deadly germ exposure
Lab students were supposed to ID a mild germ. They all identified a deadly pathogen.
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Reposted by Mitchell Dumais, MD
Kai Kupferschmidt @kakape.bsky.social · 24/07/2026
Another massive jump in Ebola cases in DRC (reflecting new cases as well as "data harmonization"). Now 2,905 cases including 1,269 deaths. I find it harder every day to square the size and speed of spread of this outbreak with the lack of attention it is getting. insp.cd/sitrep-n069-...
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Reposted by Mitchell Dumais, MD
Kai Kupferschmidt @kakape.bsky.social · 13/07/2026
The Ebola outbreak in the DRC keeps growing at a shocking pace. We're already close to 2000 confirmed cases. Right now: 1926 confirmed cases (incl. 53 new cases in the last 24 hours) 702 of these have died insp.cd/sitrep-n058-...
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Reposted by Mitchell Dumais, MD
Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 07/07/2026
Tetanus is returning. In the 1930s, Tetanus was widespread in the US. The development & deployment of vaccines reduced annual cases from ~ 600 in the 1940s to 17 in 2020. Mortality dropped 99%. There is no cure for tetanus. We have forgotten how life was before vaccines. 🧪 archive.today/c6QVx
nationalgeographic.com
Tetanus is making a comeback. There’s an easy way to fight back.
It's easy to dismiss, but more Americans died from tetanus last year than any year in nearly two decades.
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Reposted by Mitchell Dumais, MD
Onisillos @onisillos.bsky.social · 01/07/2026
"Paying reviewers not only led to faster first editorial decisions — an average of 5.5 working days, down from nearly 38 for unpaid reviews … — but review quality" www.nature.com/articles/d41...
nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal which paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Reposted by Mitchell Dumais, MD
Forbes @forbes.com · 18/05/2026
The CDC had earlier announced it was supporting “interagency partners” to coordinate the safe withdrawal of “a small number of Americans” from the country.
forbes.com
Americans In Congo Reportedly Exposed To Ebola Outbreak—One May Have Symptoms
The CDC had earlier announced it was supporting “interagency partners” to coordinate the safe withdrawal of “a small number of Americans” from the country.
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Mitchell Dumais, MD @mitchdumais.bsky.social · 14/05/2026
So glad we could share our experience with a HSCT patient presenting with invasive Lomentospora infection and cholecystitis. What a privilege it is to work with such amazing and knowledgeable colleagues. rdcu.be/fiLuC
rdcu.be
Non-Candida fungal cholecystitis - an uncommon occurrence even in the right host
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Reposted by Mitchell Dumais, MD
Kathleen Bachynski @bachynski.bsky.social · 06/05/2026
“Authorities confirmed the Andes strain, which can be spread among people, was identified in passengers aboard the Hondius… The WHO confirmed that there were now three confirmed cases and five suspected cases of hantavirus”
nbcnews.com
3 passengers evacuated from hantavirus-hit cruise ship as new case is confirmed in Switzerland
Authorities confirmed Wednesday that the Andes strain, which can be spread among people, was identified in passengers. A local leader meanwhile opposed allowing it to dock in Spain.
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Reposted by Mitchell Dumais, MD
Kristian G. Andersen @kgandersen.bsky.social · 05/05/2026
Updates on the hantavirus situation from WHO (which we, beyond belief, are no longer part of). Seven suspected cases, three deaths. Case 1 boarded Apr 1, got sick Apr 6, died Apr 11. Likely Andes virus, given Argentina link. Consistent with infection before boarding. www.who.int/emergencies/...
who.int
Hantavirus cluster linked to cruise ship travel, Multi-country
On 2 May 2026, a cluster of passengers with severe respiratory illness aboard a cruise ship was reported to the World Health Organization. The ship is carrying 147 passengers and crew. As of 4 May 202...
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Mitchell Dumais, MD @mitchdumais.bsky.social · 03/05/2026
... How? bbc.com/news/article...
bbc.com
Three dead in suspected hantavirus outbreak on Atlantic cruise ship
The World Health Organization said one case of hantavirus infection has been confirmed, with five more suspected cases under investigation.
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Reposted by Mitchell Dumais, MD
Amesh Adalja @ameshaa.bsky.social · 17/04/2026
“Testing showed that samples from patients tested negative for more than 200 pathogens..This includes Ebola and Marburg virus diseases, Rift Valley fever, yellow fever, and Crimean-Congo hemorrhagic fever.” www.cidrap.umn.edu/misc-emergin...
cidrap.umn.edu
At least 5 dead in Burundi from a mystery illness: Africa CDC
Lab tests are negative for more than 200 pathogens, but testing continues.
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Reposted by Mitchell Dumais, MD
Ashwin Varma @ashwinvarma97.bsky.social · 05/04/2026
Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.
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Reposted by Mitchell Dumais, MD
Jeremy Kamil @macroliter.bsky.social · 04/04/2026
🧪 intriguing slightly macabre read for ID physicians, public health folks, or the the simply host microbe curious 🔬🧫 wapo.st/4twprKU
wapo.st
He couldn’t think, eat or recover — and no one knew why
Doctors were stumped by an Oregon man’s deterioration. Then an infectious disease specialist had an aha moment.
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Mitchell Dumais, MD @mitchdumais.bsky.social · 20/03/2026
Mine are "Doxy" and "Mino"... Doxy was mom, and she was pregnant (unknown to me when I picked her). So her derivative has to be another tetracycline 🐱
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Reposted by Mitchell Dumais, MD
Amesh Adalja @ameshaa.bsky.social · 13/03/2026
In this @ofidjournal.bsky.social paper, my @centerforhealthsecurity.org colleagues & I discuss the way AI can facilitate/accelerate the development of countermeasures for biothreat agents & the need to create a robust data ecosystem to enable such an endeavor academic.oup.com/ofid/article...
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Reposted by Mitchell Dumais, MD
Liz Highleyman @lizhighleyman.bsky.social · 26/02/2026
People taking more complex regimens to treat HIV could soon have a new once-daily single-tablet option. #CROI2026 www.poz.com/article/bict...
poz.com
Bictegravir/Lenacapavir Combo Pill Could Replace Complex HIV Treatment
The two-drug single-tablet regimen could enable people to switch from antiretroviral regimens containing multiple pills.
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Reposted by Mitchell Dumais, MD
John Ross @johnrossmd.bsky.social · 26/02/2026
This just in: the B/Yamagata lineage of influenza B is still extinct
nature.com
Unraveling the mechanism behind the probable extinction of the B/Yamagata lineage of influenza B viruses - Nature Communications
Influenza B/Yamagata lineage has rarely been detected since COVID-19 non-pharmaceutical interventions were introduced, while transmission of other influenza lineages resumed. Here, the authors investi...
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Reposted by Mitchell Dumais, MD
Kathleen Bachynski @bachynski.bsky.social · 26/02/2026
“Seven elephant seal pups at Año Nuevo State Park have tested positive for the virus, known as H5N1, becoming the first recorded cases in northern elephant seals. They are among about 30 seals that have died at the park since late last week and the first to have been tested, said Roxanne Beltran”
nytimes.com
Bird Flu Strikes California Elephant Seals for the First Time
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Mitchell Dumais, MD @mitchdumais.bsky.social · 25/02/2026
The STOMP/A5418 Trial is out: - Clinical Resolution: 83% tecovirimat, 84% placebo - No significant differences in pain, time to lesion healing, or viral DNA clearance - Similar results to PALM007 for clade 1 MPXV *Tecovirimat seems to lack efficacy in clade I and II www.nejm.org/doi/full/10....
nejm.org
Tecovirimat for the Treatment of Mpox | NEJM
Tecovirimat is approved for smallpox treatment under the Food and Drug Administration Animal Rule on the basis of efficacy in nonhuman primate models of mpox (previously known as monkeypox). Howeve...
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Mitchell Dumais, MD @mitchdumais.bsky.social · 23/02/2026
It's Day 1 of #CROI2026 and I'm already wanting to come back next year! Of course, going to San Diego doesn't hurt 🌞
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Reposted by Mitchell Dumais, MD
Jonathan Ryder, MD @jonathanrydermd.bsky.social · 22/02/2026
New from @cidjournal.bsky.social and Mayo Clinic, a modern cohort of Legionella PNA: 344 adults with Legionella (85% L pneumophila) 1/3rd ICU, 1/8 died at 30 days Urine Ag only + test in 42.4%, but among those with +PCR/Cx, UAg+ in only 25.6% #IDSky #Legionella academic.oup.com/cid/advance-...
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Reposted by Mitchell Dumais, MD
BK. Titanji @boghuma.bsky.social · 19/02/2026
Another example of how mRNA vaccine technology is revolutionizing medicine in real time. Individualized mRNA vaccination triggered robust anti-tumor T cell responses in triple negative breast cancer leading to durable cancer remission. www.nature.com/articles/s41...
nature.com
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature
In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.
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Reposted by Mitchell Dumais, MD
derek guy @dieworkwear.bsky.social · 18/02/2026
some of you are looksmaxxing when you need to be booksmaxxing
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Reposted by Mitchell Dumais, MD
Eric Topol @erictopol.bsky.social · 18/02/2026
In people age 50+, the Covid booster halved hospitalization and deaths. Waning of benefit after 3-6 months For the mRNA BA.1 booster vs no shot after initial vaccination www.sciencedirect.com/science/arti...
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Mitchell Dumais, MD @mitchdumais.bsky.social · 16/02/2026
*all studies were normal! We need an edit button 😅
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Reposted by Mitchell Dumais, MD
BK. Titanji @boghuma.bsky.social · 16/02/2026
Whenever I am he ID consults, we occasionally get paged for a suspected "Zebra". 99% of the time it is not a "Zebra". Just a regular "Horse" that could have been solved by a good history, physical examination and chart review. ID docs are not wizards we simply talk to patients and are thorough :)
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Mitchell Dumais, MD @mitchdumais.bsky.social · 16/02/2026
My favorite consult was an outpatient ID referral for "blue legs" I saw with a preceptor. Had purplish-blue legs from the hips down, symmetric, no pain. Vascular studies, CT scan, Ultrasound, labs all performed areceptor. He had a new unwashed pair of jeans and the blue dye was rubbing off!
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Mitchell Dumais, MD @mitchdumais.bsky.social · 16/02/2026
Don't get me wrong, I LOVE being a physician. No other career I would choose. But in the past 48 hours, friends/family have called/texted me about: - "I had sepsis!" (they did not) - seizure in the gym - multiple children with febrile illness overseas - anaphylaxis Do I charge them coffee? 😅
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Reposted by Mitchell Dumais, MD
Eric Topol @erictopol.bsky.social · 09/02/2026
Coffee and improved cognition, reduced dementia >130,000 people followed 37 years Benefit seen only with caffeinated coffee or tea and most pronounced ~2 cups/day @jama.com ☕️☕️https://jamanetwork.com/journals/jama/fullarticle/2844764
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Reposted by Mitchell Dumais, MD
Scientific American @sciam.bsky.social · 05/02/2026
The South Carolina measles outbreak has triggered rare but serious brain swelling in some children
scientificamerican.com
Brain swelling is one of measles’ nastiest side effects, and it’s happening in South Carolina
The South Carolina measles outbreak has triggered rare but serious brain swelling in some children
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Reposted by Mitchell Dumais, MD
Patrick Ching @patrickching.bsky.social · 01/02/2026
No #HBV reactivation/incident infxn in PLH w isolated anti-HBc after switching to CAB/RPV #HIV #IDSky #MedSky academic.oup.com/cid/advance-...
academic.oup.com
Hepatitis B Outcomes After Switching to Long-Acting Cabotegravir/Rilpivirine in People With HIV: Reactivation, Incident Infection, and Liver Safety Across Diverse Serological Profiles
This prospective cohort followed 741 people with HIV switching to long-acting intramuscular cabotegravir/rilpivirine. No hepatitis B virus (HBV) incident i
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