Glioma-derived guanidinoacetate depolarizes neighboring neurons through γ-aminobutyric acid (GABA) A receptors, and depleting this metabolite reduces both neuronal activity and glioma growth.

A genetic mouse model of IDH-mutant glioma responds to mutant IDH inhibitor (mIDHi) and shows that prior mIDHi treatment improves response to chemoradiation.

Nature Metabolism, Published online: 29 April 2026; doi:10.1038/s42255-026-01520-0This study develops a platform that enables simultaneous, multiplexed tracing of 30 nitrogen isotope-labelled metabolites, uncovering differences in pyrimidine synthesis pathway choice between primitive and differentiated cells.

Nature Metabolism, Published online: 29 April 2026; doi:10.1038/s42255-026-01519-7Nitrogen metabolism is more complex and less mapped than carbon pathways owing to the diversity of nitrogen sources and disjointed routing. Savani et al. develop a multiplexed nitrogen labelling platform to trace system-wide nitrogen flows, revealing how undifferentiated and mature cells select nitrogen sources for pyrimidine nucleotide synthesis.

McBrayer Lab uses their new nitrogen metabolism profiling platform, organoid model to discover modification of enzyme CAD activates de novo pathway A cell’s development stage intrinsically determines ...