Sign in

Shirli Cohen, PhD

@microshirli.bsky.social
1.6K followers 2.5K following 3 posts

Microbiologist @ CU AMC | fungal pathogens in polymicrobial communities | maternal-fetal health | she/her

PostsRepliesMedia
Shirli Cohen, PhD @microshirli.bsky.social · 25/09/2025
Preprint alert! I’m excited to share my work identifying and characterizing the impact of fungal-bacterial nutrient sharing in the vaginal tract 🦠
062
Reposted by Shirli Cohen, PhD
Rebecca Keogh @rebecca-keogh.bsky.social · 03/09/2025
✨ Exciting News ✨I am thrilled to share that I have accepted a position as an Assistant Professor in the Department of Infectious Diseases and Microbiology (IDM), at the University of Pittsburgh School of Public Health!
21767
Reposted by Shirli Cohen, PhD
Uri Manor @manorlaboratory.bsky.social · 11/07/2025
undark.org/2025/07/11/i...
undark.org
Interview: How a Hearing-Loss Grant Got Cut in the Fight Over DEI
“It felt like the floor dropped out,” researcher Uri Manor said after the sudden suspension of his lab’s award.
22523
Reposted by Shirli Cohen, PhD
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 13/02/2025
𝗣𝗿𝗼𝘃𝗼𝗰𝗮𝘁𝗶𝘃𝗲: 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗳𝘂𝗲𝗹𝘀 𝗔𝗠𝗥 Staphylococcus aureus evolves antibiotic resistance rapidly in diabetic mice, as hyperglycemia aids the expansion and takeover of resistant mutants VISA strains have a large fitness defect in control mice but not in diabetic mice ➡️ www.science.org/doi/10.1126/...
science.org
Diabetes potentiates the emergence and expansion of antibiotic resistance
Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.
47323
Reposted by Shirli Cohen, PhD
Dr. Stephanie Marroquin @marroquinphd.bsky.social · 08/02/2025
Spots are filling up for the 2025 Microbial Adhesion and Signal Transduction GRC and GRS! Apply to join us July 19-25 at Salve Regina University! It’s going to be a great meeting with amazing science and people! Please re-post!! #MAST
021
Reposted by Shirli Cohen, PhD
Rebecca Keogh @rebecca-keogh.bsky.social · 14/01/2025
Applications are open for the 2025 GRS/GRC on Staphylococcal Diseases! Make sure to get your abstracts submitted for the potential to present your work in beautiful Barcelona! www.grc.org/staphylococc...
02822
Reposted by Shirli Cohen, PhD
Sorek Lab @soreklab.bsky.social · 30/01/2025
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab! www.nature.com/articles/s41...
419366
Reposted by Shirli Cohen, PhD
Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 24/01/2025
Research supplements to support URM mentees are set to expire today. I met the person who developed this mechanism, Clifton Poodry, at an NSF meeting last fall; he is so inspiring. This supplement has funded thousands of mentees including myself. Devasted to see it canceled, and with no notice.
grants.nih.gov
PA-23-189: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed) PA-23-189....
611851
Reposted by Shirli Cohen, PhD
Judith Berman @judithberman11.bsky.social · 18/01/2025
Valley fever, or coccidioidomycosis is on the move—endemic to the SW USA, but with increasing hot, dry conditions its being found farther north! Nice story on it in Science www.sciencemagazinedigital.org/sciencemagaz...
sciencemagazinedigital.org
Science Magazine - Dust devil
In the spring of 2021, shortly after moving from Seattle to Arizona, Marc Evans, a retired broadcast industry lawyer, began tending the vegetable garden in his niece’s backyard.
097
Reposted by Shirli Cohen, PhD
Guillaume Méric @gmeric.bsky.social · 16/01/2025
You've heard of FMT, have you heard of NMT (nasal microbiota transplantation)? 👃 This brief piece in Trends discusses 2 recent studies exploring NMT to treat chronic respiratory conditions, like rhinosinusitis (CRS). 🔗 www.sciencedirect.com/science/arti...
0125
Reposted by Shirli Cohen, PhD
David Finlay @davidfinlaytcd.bsky.social · 15/01/2025
More nice research from Annie Curtis’ lab on the circadian rhythm and the #immunometabolism of macrophages. #immunosky #mitochondria #inflammasome Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages
The circadian clock, orchestrated by BMAL1, regulates the expression of Nlrp3 and Il1b in response to lipopolysaccharide (LPS), causing time-of-day production of pro-IL-1β. Mitochondria exhibit time-....
1219
Reposted by Shirli Cohen, PhD
Katy Patras @katypatras.bsky.social · 10/01/2025
After almost a decade (started while I was a postdoc with @nizet.bsky.social and finished by my own stellar students), happy to see this finally out. We found that Tamm-Horsfall protein, the most abundant protein in urine, enhanced NETosis to protect against UTI. insight.jci.org/articles/vie...
insight.jci.org
JCI Insight - Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection
33010
Reposted by Shirli Cohen, PhD
MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 29/12/2024
40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.
15559215
Reposted by Shirli Cohen, PhD
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 25/12/2024
Bizarre and cool Flies have stolen the gene encoding a toxin from bacteria and deployed it to survive predation by parasitic wasps, which in some flies can turn half of all fly larvae into surrogate wombs for baby wasps @nkwhiteman.bsky.social lab at UC Berkeley recapitulates this in Drosophila.
cell.com
Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
Tarnopol et al. recapitulate the horizontal transfer of anti-parasitoid toxins from microbes to insects in D. melanogaster. Immune tissue expression of one toxin gene, fusionB, was sufficient to drive parasitoid resistance in flies via the humoral innate immune pathway.
2539
Reposted by Shirli Cohen, PhD
Ed Chuong @edchuong.bsky.social · 12/12/2024
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
cell.com
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
1215774
Reposted by Shirli Cohen, PhD
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 03/12/2024
Early prediction of preeclampsia using the first trimester vaginal microbiome www.biorxiv.org/content/10.1101/202…
biorxiv.org
Early prediction of preeclampsia using the first trimester vaginal microbiome https://www.biorxiv.org/content/10.1101/2024.12.01.626267v1
Preeclampsia is a severe obstetrical syndrome which contributes to 10-15% of all maternal deaths. Al
011
Reposted by Shirli Cohen, PhD
JAMA @jama.com · 28/11/2024
Cervical cancer mortality in US women younger than 25 years significantly declined between 2016 and 2021, likely due to the widespread adoption of HPV vaccination. ja.ma/4i9ghPC
322052612
Reposted by Shirli Cohen, PhD
Drew Bridges @bridgesbio.bsky.social · 26/11/2024
Excited to share our latest, "Biofilm dispersal patterns revealed using far-red fluorogenic probes." @plos.bsky.social We developed a cell-labeling strategy using far-red dyes to image dense microbial communities (where fluorescent proteins often do not work well) journals.plos.org/plosbiology/...
310332
Reposted by Shirli Cohen, PhD
Ákos T Kovács @evolvedbiofilm.bsky.social · 24/11/2024
Bacterial single-cell RNA sequencing captures biofilm transcriptional heterogeneity and differential responses to immune pressure -in #NatureCommunications by Lee Korshoj and Tammy Kielian www.nature.com/articles/s41...
04227
Reposted by Shirli Cohen, PhD
Greg Pak @gregpak.net · 18/11/2024
Relatedly, I buy my KN-95 masks from @bonafidemasks.bsky.social, and right now you can use coupon code TRUST25 for a 25% discount. No, this is not paid advertisement. I've just used 'em for years and have had great experiences. bonafidemasks.com/powecom-kn95/
bonafidemasks.com
Powecom® KN95 - Page 1 - Bona Fide Masks
Like the N95, the FDA Authorized KN95 face masks sold by Bona Fide Masks™ are rated to provide 95% ore greater filtration of particles larger than 0.3 µm in diameter such as bacteria, viruses, dust & ...
1324784
Reposted by Shirli Cohen, PhD
Tobias Hohl, MD PhD @fungalspore.bsky.social · 17/11/2024
go.bsky.app/2bqX3T7 - please send me your @bsky.app handles to include in this growing community.
8210157
Reposted by Shirli Cohen, PhD
Lauren Palmer @laurenpalmer.bsky.social · 15/11/2024
SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜
rdcu.be
Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice
Nature Microbiology - Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by...
1416348
Reposted by Shirli Cohen, PhD
Souvik Bhattacharyya @souvik-uthealth.bsky.social · 12/11/2024
Hello Blueskis. Here is a starter pack of General Microbiology. It's a small list currently. Please feel free to self-nominate and I will add you. go.bsky.app/QgSQHJ9
12711066
Reposted by Shirli Cohen, PhD
Aude Bernheim @audeber.bsky.social · 13/11/2024
To celebrate all these new arrivals on BlueSky, did you see this recent preprint on the role of amyloïd in anti-phage defense? Molecular characterization of amyloid as signal transduction in E. coli phage defense, with super cool links wt fungi controlled cell death! www.biorxiv.org/content/10.1...
biorxiv.org
Amyloid signaling in antiphage defense
Immune regulated cell death (RCD) is a defense strategy common to different domains of life involving purposeful sacrifice of infected cells. In animals and fungi, functional amyloids play a role in t...
15016
Reposted by Shirli Cohen, PhD
Jessica Brown Lab @brownlabutah.bsky.social · 12/11/2024
The Medical Mycology Trainee Seminar Series is back! Our next seminar is November 14th at 4 pm GMT (5 pm Central Europe Time, 11 am Eastern Standard, 8 am Pacific Standard, 12 am in China). 1/12
1139
Shirli Cohen, PhD @microshirli.bsky.social · 11/11/2024
Hi! I’m a PhD candidate at the University of Colorado studying the ways that fungi and bacteria interact with each other in the vaginal tract and how they impact adverse pregnancy outcomes and fetal/neonatal infection. I’m a big fan of microscopy, my dog, and spreading the word about cool microbes!
Me and my golden retriever. The ground is covered in snow and we are both looking at the camera with big smiles.
0161