New preprint out by PhD student @madshartmann.bsky.social 🥳
We present SCAR, the perfect tool for assessing the impact of #ancientDNA damage on analyses
Validation tests show how damage massively impacts heterozygosity estimates 😨
Check it out here
www.biorxiv.org/content/10.6...
biorxiv.org
SCAR: Controlled mutations, ancient DNA damage, and fragmentation of fasta and fastq sequences
Summary: Controlled modification of sequencing data is important for reproducible benchmarking, particularly when evaluating analyses affected by read fragmentation, divergent reference genomes and an...