iiinova — where your digital self keeps evolving

Michael Hoffman @michaelhoffman.bsky.social · 11/06/2026

The Tribunal indeed does not seem pleased www.omb.gov.on.ca/e-decisions/...

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Michael Hoffman @michaelhoffman.bsky.social · 11/06/2026

Wild that Gaithersburg, MD, just has a NIST-shaped hole in the middle.

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Michael Hoffman @michaelhoffman.bsky.social · 08/06/2026

Look for route 12 here. They do not make this especially easy to find www.gotransit.com/en/see-sched...

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Michael Hoffman @michaelhoffman.bsky.social · 27/05/2026

I don't usually comment on whether notables should have been awarded funding in some competition, not having seen the application or the competition. But this sort of thing on previously awarded grants that have been recommended funding in multiple rounds of expert review should not be happening:

In 2025, Eddy received a letter from the National Institutes of Health, informing him that his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," he recalls.

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Michael Hoffman @michaelhoffman.bsky.social · 25/05/2026

@shawnmicallef.bsky.social Simon Fraser University really has commitment to the brutalist bit.

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Michael Hoffman @michaelhoffman.bsky.social · 14/05/2026

ASHG (@geneticssociety.bsky.social) is proposing bylaw changes that include removing its commitment to diversity in committee appointments. A sad day.

Section 2: APPOINTMENT, SERVICE. Committee members, except those serving by virtue of holding other office, shall be appointed by the President in consultation with the Executive Committee, and may be removed by a majority vote of the Board of Directors. The President’s appointments shall, to the extent possible, reflect the diversity of the Society’s membership. The President shall designate the chairperson of each committee, also in consultation with the Executive Committee. F The Board may add or remove standing committees and may effect changes in the composition of standing committees – including the number of members and rotation schedules – by majority vote and without amendment of these Bylaws. Committees and other working groups may meet in person or by remote communication. The standing committees are:

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Michael Hoffman @michaelhoffman.bsky.social · 14/05/2026

Looks like a number of other cities interested in this too so I'm wondering if they think this sets some sort of precedent that must be addressed.

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Michael Hoffman @michaelhoffman.bsky.social · 14/05/2026

Also unusual, looks like the ABC Residents' Association joined the OLT proceeding as a Party in support of the applicant!

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Michael Hoffman @michaelhoffman.bsky.social · 14/05/2026

Why are some parents so concerned about this and not all the announced TDSB staffing cuts? Oh.

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Michael Hoffman @michaelhoffman.bsky.social · 14/05/2026

This is what is I replied to one of these things in a parents' group. I don't want to spend too much effort on this but it annoys me to see the misinformation and NIMBY fearmongering spread so widely

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Michael Hoffman @michaelhoffman.bsky.social · 07/05/2026

I'll never forget Juliet showing me around Barbados, a place she loved.

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Michael Hoffman @michaelhoffman.bsky.social · 28/04/2026

The OED should have added a TLC quotation!

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Michael Hoffman @michaelhoffman.bsky.social · 20/04/2026

Dear lord

$WITH astronauts AS ( SELECT * FROM 'astronauts.parquet' QUALIFY ROW_NUMBER() OVER ( PARTITION BY name ORDER BY mission_number DESC ) = 1 ) SELECT *, year_of_selection - year_of_birth AS age, 'Age at selection' AS category FROM astronauts UNION ALL SELECT *, year_of_mission - year_of_birth AS age, 'Age at mission' AS category FROM astronauts VISUALIZE age AS x, category AS fill DRAW histogram SETTING binwidth => 1, position => 'identity' PLACE rule SETTING x => (34, 44), linetype => 'dotted' PLACE text SETTING x => (34, 44, 60), y => (66, 49, 20), label => ( 'Mean age at selection = 34', 'Mean age at mission = 44', 'John Glenn was 77\non his last mission -\nthe oldest person to\ntravel in space!' ), hjust => 'left', vjust => 'top', offset => (10, 0) SCALE fill TO accent LABEL title => 'How old are astronauts on their most recent mission?', subtitle => 'Age of astronauts when they were selected and when they were sent on their mission', x => 'Age of astronaut (years)', fill => null$

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Michael Hoffman @michaelhoffman.bsky.social · 17/04/2026

Combined with Conservative MPPs giving themselves months and months off, more and more the Ontario Legislative Assembly just seems to be a rubber stamp for Doug Ford cosplaying as a legitimate legislature.

When Clark was asked Thursday if he planned to allow the current budget bill to have public hearings — after it had been sitting for two weeks at the committee stage with no movement — he was cagey.

"I've made no decisions," he said, a couple of hours before tabling his 1,238-word motion.

The motion also seeks to schedule one day each of public hearings on a bill that overhauls school board governance and another that prevents municipalities from requiring that developments follow certain environmentally friendly standards.

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Michael Hoffman @michaelhoffman.bsky.social · 17/04/2026

DAE abbreviate the "accessibility" in "chromatin accessibility" as "a11y"? I suspect Google AI Overview is making stuff open when it says "often" in bioinformatics contexts.

Chromatin accessibility (often abbreviated or related to the concept of a11y in bioinformatics contexts, particularly when referring to open, accessible regions) refers to the degree to which nuclear DNA is accessible toDNA-binding proteins, such as transcription factors, histones, and RNA polymerase. It is a critical aspect of gene regulation, as inaccessible (compacted) chromatin restricts protein access, while open (accessible) chromatin allows for transcriptional activation

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Michael Hoffman @michaelhoffman.bsky.social · 25/03/2026

2/Out of 288 total combinations, 14 showed some variation in results for the repetition. I'm not surprised that there is variation but am a little surprised by the pattern of what does and does not have variation.

Project Control
Peak
Type
Aligner
Peak
Caller
Deduplicator Peak Count Range
Difference in
Called Peaks
Rube
No
Control
Broad STAR
Genrich Sambamba 252158-252160 2
MACS3 Sambamba 1157876-1157882 6
Narrow STAR
Genrich Sambamba 252158-252160 2
MACS3 Sambamba 1168345-1168346 1
With
Control
Broad STAR
Genrich Sambamba 127542-127543 1
MACS3
No
Deduplication
1002670-1002671 1
Sambamba 1004044-1004045 1
PePr Sambamba 568554-568556 2
Narrow
STAR
Genrich Sambamba 127542-127543 1
MACS3 Sambamba 1143541-1143542 1
PePr
No
Deduplication
1713483-1713484 1
Sambamba 721307-721309 2
BWAMEM
Cisgenome
Picard 15553-175097 159544
Sambamba 15553-35909 20356

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Michael Hoffman @michaelhoffman.bsky.social · 25/03/2026

1/The Rocketchip paper authors repeated peak calling 3 times for each combination of 2 datasets × 2 control types × 2 peak types × 3 aligners × 4 deduplicators × 4 peak callers. www.biorxiv.org/content/10.1...

Figure 2. Peak Counts for all Software Combinations. ChIP-seq data from Namani et al.
2019 and Rube et al. 2016 were run through all software combinations in Rocketchip three
times each. Raw peak counts were log2 transformed and plotted in the heatmap. Darker red
corresponds to higher peak counts while darker blue corresponds to lower peak counts. Gray
corresponds to “NA” values, as PePr and CisGenome cannot be run without a control. The
heatmap was created using R (v4.2.3) with a kernel (r-irkernel v1.3.2) in Jupyter Notebook
(v1.0.0) using the following packages: ComplexHeatmap (v2.14.0), dplyr (v1.1.4), tidyr (v1.3.1),
reshape2 (v1.4.4), stringr (v1.5.1), and MASS (v7.3.60.0.1).

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Michael Hoffman @michaelhoffman.bsky.social · 25/03/2026

Sankofa is great when there's an event on but I think it's eh the rest of the time. Berczy is great though

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Michael Hoffman @michaelhoffman.bsky.social · 24/03/2026

This is the TDSB's reasons for appeal. The OLT sent me the record in the case file which is 711 pages and counting.

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Michael Hoffman @michaelhoffman.bsky.social · 23/03/2026

Putting this map on the website that clearly shows the sports court not overlapping with the soccer field doesn't stop people from spreading this misinformation months later. www.toronto.ca/city-governm...

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Michael Hoffman @michaelhoffman.bsky.social · 14/03/2026

1970s Joy of Cooking should be the official Toronto cookbook

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Michael Hoffman @michaelhoffman.bsky.social · 11/03/2026

One of the things that Canada does well nserc-crsng.canada.ca/en/funding/r...

Paid maternity/parental leave for students and postdoctoral fellows

The Agencies will provide maternity/parental leave supplements within 12 months following a child’s birth or adoption to eligible students and postdoctoral fellows who are paid out of agency grants and who are the child’s primary caregivers. The supplement paid to the grant recipient will be based on the students’ and/or postdoctoral fellows’ current salary/stipend from the grant for up to 12 months to cover the leave period.

The agency-paid portion of parental leave is only eligible during the grant’s authority to use funds period as it is based on the agency-funded annual salary or stipend, not on other funding sources.

If both parents are supported by grant funds, each parent may take a portion of the leave for a combined maximum of 12 months. The supplement will be pro-rated if the student or postdoctoral fellow is being trained in research on a part-time basis.

The administering institution is responsible for submitting a request for paid maternity/parental leave supplements to students and postdoctoral fellows by completing the Grant Amendment Form for the relevant agency’s approval.

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Michael Hoffman @michaelhoffman.bsky.social · 04/03/2026

Subtract 30, divide by 2 is a decent approximation to converting from degrees Farenheit to degrees Celsius across ambient temperatures.

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Michael Hoffman @michaelhoffman.bsky.social · 04/03/2026

This is a common misunderstanding. The U.S. has agreed to the UN headquarters district's inviolability but it is still U.S. territory. Not that this justifies the abhorrent comments of the U.S. representative.