iiinova — where your digital self keeps evolving

Jason McLellan @mclellanlab.bsky.social · 22/06/2026

Had a great time at the match watching Messi score 2!!

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Jason McLellan @mclellanlab.bsky.social · 15/04/2026

My daughter was invited on stage to help Neil deGrasse Tyson @neildegrassetyson.com post a Tweet!

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Jason McLellan @mclellanlab.bsky.social · 02/03/2026

Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!

Cryo-EM structures of prefusion HSV-2 gB in complex with human antibodies.

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Jason McLellan @mclellanlab.bsky.social · 27/01/2026

Our third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.

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Jason McLellan @mclellanlab.bsky.social · 01/01/2026

New Year's Eve Red Wings game with the family!

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Jason McLellan @mclellanlab.bsky.social · 01/11/2025

Completed with 100% yesterday. Gearing up for some speed runs now.

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Jason McLellan @mclellanlab.bsky.social · 31/10/2025

Happy Halloween! My daughter is dressed as Hornet from Silksong, the game I've spent 60 hours playing the past two months

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Jason McLellan @mclellanlab.bsky.social · 19/08/2025

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

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Jason McLellan @mclellanlab.bsky.social · 18/06/2025

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

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Jason McLellan @mclellanlab.bsky.social · 20/05/2025

Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...

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Jason McLellan @mclellanlab.bsky.social · 18/05/2025

Getting ready for the Viruses and Cells GRC in Castelldefels

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Jason McLellan @mclellanlab.bsky.social · 07/05/2025

New exhibit at the National Inventors Hall of Fame 👀

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Jason McLellan @mclellanlab.bsky.social · 25/03/2025

We just had our first grant terminated. This was a U19 AViDD grant (grants.nih.gov/grants/guide...). It was set to end next month, although many in the consortia were hoping for NCEs.

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Jason McLellan @mclellanlab.bsky.social · 29/12/2024

Taking the family to their first Red Wings game!

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Jason McLellan @mclellanlab.bsky.social · 06/12/2024

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Jason McLellan @mclellanlab.bsky.social · 13/11/2024

My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝

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Jason McLellan @mclellanlab.bsky.social · 12/10/2024

ACL Music Festival! Teddy Swims on stage.

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Jason McLellan @mclellanlab.bsky.social · 09/03/2024

Saw Road House with the cast at SXSW!

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Jason McLellan @mclellanlab.bsky.social · 02/10/2023

My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286

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Jason McLellan @mclellanlab.bsky.social · 02/10/2023

My babies are the October Molecule of the Month pdb101.rcsb.org/motm/286

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Jason McLellan @mclellanlab.bsky.social · 17/03/2023

Well, this is new (to me). Seems like a low bar for authorship...

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Jason McLellan @mclellanlab.bsky.social · 12/03/2023

Great to see some old friends from the Vaccine Research Center days

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Jason McLellan @mclellanlab.bsky.social · 05/12/2022

Checked in and ready for the start of #AVS11 @AusVirologySoc! Amazing view from the room😍

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Jason McLellan @mclellanlab.bsky.social · 31/10/2022

Happy Halloween from the McLellan Lab:)

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Jason McLellan @mclellanlab.bsky.social · 16/08/2022

Check out our manuscript reporting the structure of the αMβ2 integrin bound to the adenylate cyclase toxin from B. pertussis! www.cell.com/cell-reports/fulltext/… Lots of cool new biological insights. Great work from grad student @JoryGoldsmith in...

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Jason McLellan @mclellanlab.bsky.social · 04/08/2022

Great day on Lake Travis with the lab

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Jason McLellan @mclellanlab.bsky.social · 20/07/2022

A great night with @erwright73 and colleagues at @RARE_Madison. Got to meet J. Henry and try some @JHenryBourbon before finishing off that tomahawk steak dry-aged for 2 months!

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Jason McLellan @mclellanlab.bsky.social · 18/07/2022

Thanks @erwright73 for showing me around the National CryoET Center. Incredible setup, every toy imaginable! Plus, I got to try some George T Stagg HAZMAT Edition! 😍

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Jason McLellan @mclellanlab.bsky.social · 10/06/2022

Received an email from Rino Rappuoli this morning informing me, @BarneyGrahamMD and Peter Kwong of the positive phase III data for the RSV prefusion F vaccine results in older adults. It's been almost 10 years since we designed the first prefusion RSV F antigen, DS-Cav1. Amazing!

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Jason McLellan @mclellanlab.bsky.social · 03/06/2022

Took a break from the Keystone Symposium in Breckenridge CO to take the family whitewater rafting. Kids had a blast!

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Jason McLellan @mclellanlab.bsky.social · 24/05/2022

I wore a jacket today just to make @BarneyGrahamMD happy. You can tell how pleased he is :)

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Jason McLellan @mclellanlab.bsky.social · 20/05/2022

Check out this review article from my postdoc Pat Byrne (@antigenman) on structure-based vaccine antigen design! authors.elsevier.com/a/1f63R3OeyGDh…

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Jason McLellan @mclellanlab.bsky.social · 04/05/2022

My wife and son dropped by the lab with baked goods for May 4th, just like old times. Check out that Sarlacc pit cake!

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Jason McLellan @mclellanlab.bsky.social · 02/05/2022

Promising results from @pfizer's Phase 2b prefusion RSV F maternal immunization study. Nice boost in neut titers in the mothers and infants. N Engl J Med 2022; 386:1615-1626. DOI: 10.1056/NEJMoa2106062

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Jason McLellan @mclellanlab.bsky.social · 09/04/2022

Junior Ninja Warrior course in Austin today. Gavin and Kaia are having a great time!

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Jason McLellan @mclellanlab.bsky.social · 28/03/2022

Congrats to Dr Akaash Mishra @AkaashMishra88 on his PhD thesis defense! Beautiful work on the structure and function of CCHFV glycoproteins and protective human antibodies. Next stop, Merck!

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Jason McLellan @mclellanlab.bsky.social · 18/03/2022

Enjoying a weekend in Ghent with my wife to celebrate @BarneyGrahamMD receiving an honorary doctorate!

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Jason McLellan @mclellanlab.bsky.social · 14/03/2022

Our manuscript describing structure-based design of hMPV F antigens is out: rdcu.be/cIUNM. Great work led by Ching-Lin Hsieh and Scott Rush, in collaboration with Vicente Mas. Expected to start Phase 1 trials in H2 2022: icosavax.com/vlp-vaccine-pipeline.

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Jason McLellan @mclellanlab.bsky.social · 26/11/2021

At the Longhorns game with my oldest. Hook 'em!

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